Granulins rescue inflammation, lysosome dysfunction, lipofuscin, and neuropathology in a mouse model of progranulin deficiency

Granulins rescue inflammation, lysosome dysfunction, lipofuscin, and neuropathology in a mouse model of progranulin deficiency

Summary: Progranulin (PGRN) deficiency is linked to neurodegenerative diseases, including frontotemporal dementia (FTD), Alzheimer’s disease, and Parkinson’s disease. Proper PGRN levels are critical for brain health; however, the function of PGRN is unclear. PGRN is composed of 7.5 repeat domains, c...

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Main Authors: Jessica Root, Anarmaa Mendsaikhan, Georgia Taylor, Paola Merino, Srijita Nandy, Minzheng Wang, Ludmilla Troiano Araujo, Danny Ryu, Christopher Holler, Bonne M. Thompson, Giuseppe Astarita, Jean-François Blain, Thomas Kukar
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724013366
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http://www.sciencedirect.com/science/article/pii/S2211124724013366

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