Progresses in the study of polysaccharide from medicinal plants of the Asclepiadaceae family
Medicinal plants from the Asclepiadaceae family, such as Luo Mo (Metaplexis japonica Makino), Xu Changqing (Cynanchum paniculatum), and Bai Wei (Cynanchum atratum Bge.), have long been staples in Traditional Chinese Medicine (TCM) due to their wide range of pharmacological activities (Su et al., 202...
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Elsevier
2024-12-01
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| Series: | Pharmaceutical Science Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773216924000114 |
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| _version_ | 1846138103270473728 |
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| author | He Xiao Ziqing Zeng Wenjie Jiang |
| author_facet | He Xiao Ziqing Zeng Wenjie Jiang |
| author_sort | He Xiao |
| collection | DOAJ |
| description | Medicinal plants from the Asclepiadaceae family, such as Luo Mo (Metaplexis japonica Makino), Xu Changqing (Cynanchum paniculatum), and Bai Wei (Cynanchum atratum Bge.), have long been staples in Traditional Chinese Medicine (TCM) due to their wide range of pharmacological activities (Su et al., 2021) [1]. These beneficial properties are largely attributed to compounds like saponins, alkaloids, and polysaccharides. Polysaccharides, in particular, are vital components in TCM and have garnered increasing attention for their diverse therapeutic effects. Polysaccharides from Asclepiadaceae plants are reported to exhibit a variety of pharmacological activities, including anti-radiation, anti-tumor, anti-fatigue, antioxidant, anti-hyperlipidemic, immune-boosting, and liver-protective effects. These polysaccharides have complex structures made up of different monosaccharides, contributing to their wide range of activities. In this review, we provide a comprehensive summary of the isolation, purification, structural characterization, and pharmacological activities of polysaccharides from medicinal plants in the Asclepiadaceae family. We begin by outlining the methods used for the extraction, isolation, and purification of these polysaccharides. Next, we delve into the pharmacological activities of the isolated polysaccharides. Finally, we discuss the potential clinical applications of these polysaccharides in treating various diseases and highlight areas that require further investigation. |
| format | Article |
| id | doaj-art-82a6fae03d6b4981906c26b669c8ef73 |
| institution | Kabale University |
| issn | 2773-2169 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmaceutical Science Advances |
| spelling | doaj-art-82a6fae03d6b4981906c26b669c8ef732024-12-07T08:35:16ZengElsevierPharmaceutical Science Advances2773-21692024-12-012100045Progresses in the study of polysaccharide from medicinal plants of the Asclepiadaceae familyHe Xiao0Ziqing Zeng1Wenjie Jiang2Key Laboratory of Chemical Biology (Ministry of Education), Institute of Biochemical and Biotechnological Drugs, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, ChinaKey Laboratory of Chemical Biology (Ministry of Education), Institute of Biochemical and Biotechnological Drugs, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, ChinaKey Laboratory of Chemical Biology (Ministry of Education), Institute of Biochemical and Biotechnological Drugs, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China; NMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate-based Medicine, National Glycoengineering Research Center, Shandong University, Jinan, 250012, Shandong, China; Shandong Provincial Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Jinan, 250012, Shandong, China; Corresponding author. Institute of Biochemical and Biotechnological Drugs, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.Medicinal plants from the Asclepiadaceae family, such as Luo Mo (Metaplexis japonica Makino), Xu Changqing (Cynanchum paniculatum), and Bai Wei (Cynanchum atratum Bge.), have long been staples in Traditional Chinese Medicine (TCM) due to their wide range of pharmacological activities (Su et al., 2021) [1]. These beneficial properties are largely attributed to compounds like saponins, alkaloids, and polysaccharides. Polysaccharides, in particular, are vital components in TCM and have garnered increasing attention for their diverse therapeutic effects. Polysaccharides from Asclepiadaceae plants are reported to exhibit a variety of pharmacological activities, including anti-radiation, anti-tumor, anti-fatigue, antioxidant, anti-hyperlipidemic, immune-boosting, and liver-protective effects. These polysaccharides have complex structures made up of different monosaccharides, contributing to their wide range of activities. In this review, we provide a comprehensive summary of the isolation, purification, structural characterization, and pharmacological activities of polysaccharides from medicinal plants in the Asclepiadaceae family. We begin by outlining the methods used for the extraction, isolation, and purification of these polysaccharides. Next, we delve into the pharmacological activities of the isolated polysaccharides. Finally, we discuss the potential clinical applications of these polysaccharides in treating various diseases and highlight areas that require further investigation.http://www.sciencedirect.com/science/article/pii/S2773216924000114PolysaccharidePharmacological activityAsclepiadaceae familyTraditional Chinese medicine |
| spellingShingle | He Xiao Ziqing Zeng Wenjie Jiang Progresses in the study of polysaccharide from medicinal plants of the Asclepiadaceae family Pharmaceutical Science Advances Polysaccharide Pharmacological activity Asclepiadaceae family Traditional Chinese medicine |
| title | Progresses in the study of polysaccharide from medicinal plants of the Asclepiadaceae family |
| title_full | Progresses in the study of polysaccharide from medicinal plants of the Asclepiadaceae family |
| title_fullStr | Progresses in the study of polysaccharide from medicinal plants of the Asclepiadaceae family |
| title_full_unstemmed | Progresses in the study of polysaccharide from medicinal plants of the Asclepiadaceae family |
| title_short | Progresses in the study of polysaccharide from medicinal plants of the Asclepiadaceae family |
| title_sort | progresses in the study of polysaccharide from medicinal plants of the asclepiadaceae family |
| topic | Polysaccharide Pharmacological activity Asclepiadaceae family Traditional Chinese medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2773216924000114 |
| work_keys_str_mv | AT hexiao progressesinthestudyofpolysaccharidefrommedicinalplantsoftheasclepiadaceaefamily AT ziqingzeng progressesinthestudyofpolysaccharidefrommedicinalplantsoftheasclepiadaceaefamily AT wenjiejiang progressesinthestudyofpolysaccharidefrommedicinalplantsoftheasclepiadaceaefamily |