The Role of Inflammatory Cytokines and lncRNAs in the Pathogenesis of Atherosclerosis and Other Inflammatory Diseases: Focus on Sarcoidosis and Alzheimer’s Disease
Introduction Atherosclerosis, a chronic inflammatory disease of the arterial wall, remains a leading cause of morbidity and mortality worldwide. Recent advances highlight the role of inflammatory cytokines and long non-coding RNAs (lncRNAs) in its pathogenesis. Aim of the Study This study syn...
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| Format: | Article |
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Nicolaus Copernicus University in Toruń
2025-01-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/57223 |
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| author | Aldona Sokołowska Julia Buszek Piotr Czerniak Adrianna Antoszewska Weronika Bargiel Dominika Bąk Halszka Wajdowicz Mateusz Warzocha |
| author_facet | Aldona Sokołowska Julia Buszek Piotr Czerniak Adrianna Antoszewska Weronika Bargiel Dominika Bąk Halszka Wajdowicz Mateusz Warzocha |
| author_sort | Aldona Sokołowska |
| collection | DOAJ |
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Introduction
Atherosclerosis, a chronic inflammatory disease of the arterial wall, remains a leading cause of morbidity and mortality worldwide. Recent advances highlight the role of inflammatory cytokines and long non-coding RNAs (lncRNAs) in its pathogenesis.
Aim of the Study
This study synthesizes current knowledge on the interplay between cytokines and lncRNAs across these conditions, emphasizing their potential as biomarkers and therapeutic targets.
Materials and Methods
Through a systematic review of recent studies, we identify key pathways and discuss translational implications for novel interventions.
Description of the State of Knowledge
Inflammatory cytokines, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6), orchestrate immune responses that exacerbate endothelial dysfunction, foam cell formation, and plaque instability. Concurrently, lncRNAs regulate gene expression through transcriptional and post-transcriptional mechanisms, influencing cellular processes such as macrophage polarization and smooth muscle cell proliferation. Beyond atherosclerosis, these mediators are implicated in the pathogenesis of other inflammatory diseases, including sarcoidosis and Alzheimer's disease.
Conclusion
Our findings underscore the critical need for integrated approaches targeting both inflammatory mediators and epigenetic regulators to mitigate the burden of these diseases.
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| format | Article |
| id | doaj-art-82980ac705e14370897c61c2829ff49b |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-82980ac705e14370897c61c2829ff49b2025-01-12T08:22:53ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-01-013710.12775/QS.2025.37.57223The Role of Inflammatory Cytokines and lncRNAs in the Pathogenesis of Atherosclerosis and Other Inflammatory Diseases: Focus on Sarcoidosis and Alzheimer’s DiseaseAldona Sokołowska0https://orcid.org/0009-0006-8723-2593Julia Buszek1https://orcid.org/0009-0001-3832-2668Piotr Czerniak2https://orcid.org/0009-0007-3582-4586Adrianna Antoszewska3https://orcid.org/0009-0009-4518-1726Weronika Bargiel4https://orcid.org/0009-0008-5907-8159Dominika Bąk5https://orcid.org/0009-0008-0411-9064Halszka Wajdowicz6https://orcid.org/0009-0005-4454-8558Mateusz Warzocha7https://orcid.org/0009-0009-0683-3576Kliniczny Szpital Wojewódzki Nr 2 im. Świętej Jadwigi Królowej w Rzeszowie, Lwowska 60, 35-301 RzeszówUniversity of Rzeszow al. Rejtana 16c, 35-959 Rzeszow, PolandUniversity of Rzeszow al. Rejtana 16c, 35-959 Rzeszow, Poland University of Rzeszow al. Rejtana 16c, 35-959 Rzeszow, PolandUniversity of Rzeszow al. Rejtana 16c, 35-959 Rzeszow, Poland University of Rzeszow al. Rejtana 16c, 35-959 Rzeszow, PolandUniversity of Rzeszow al. Rejtana 16c, 35-959 Rzeszow, PolandUniversity of Rzeszow al. Rejtana 16c, 35-959 Rzeszow Introduction Atherosclerosis, a chronic inflammatory disease of the arterial wall, remains a leading cause of morbidity and mortality worldwide. Recent advances highlight the role of inflammatory cytokines and long non-coding RNAs (lncRNAs) in its pathogenesis. Aim of the Study This study synthesizes current knowledge on the interplay between cytokines and lncRNAs across these conditions, emphasizing their potential as biomarkers and therapeutic targets. Materials and Methods Through a systematic review of recent studies, we identify key pathways and discuss translational implications for novel interventions. Description of the State of Knowledge Inflammatory cytokines, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6), orchestrate immune responses that exacerbate endothelial dysfunction, foam cell formation, and plaque instability. Concurrently, lncRNAs regulate gene expression through transcriptional and post-transcriptional mechanisms, influencing cellular processes such as macrophage polarization and smooth muscle cell proliferation. Beyond atherosclerosis, these mediators are implicated in the pathogenesis of other inflammatory diseases, including sarcoidosis and Alzheimer's disease. Conclusion Our findings underscore the critical need for integrated approaches targeting both inflammatory mediators and epigenetic regulators to mitigate the burden of these diseases. https://apcz.umk.pl/QS/article/view/57223atherosclerosisinflammatory cytokinesAlzheimer’s diseasesarcoidosis |
| spellingShingle | Aldona Sokołowska Julia Buszek Piotr Czerniak Adrianna Antoszewska Weronika Bargiel Dominika Bąk Halszka Wajdowicz Mateusz Warzocha The Role of Inflammatory Cytokines and lncRNAs in the Pathogenesis of Atherosclerosis and Other Inflammatory Diseases: Focus on Sarcoidosis and Alzheimer’s Disease Quality in Sport atherosclerosis inflammatory cytokines Alzheimer’s disease sarcoidosis |
| title | The Role of Inflammatory Cytokines and lncRNAs in the Pathogenesis of Atherosclerosis and Other Inflammatory Diseases: Focus on Sarcoidosis and Alzheimer’s Disease |
| title_full | The Role of Inflammatory Cytokines and lncRNAs in the Pathogenesis of Atherosclerosis and Other Inflammatory Diseases: Focus on Sarcoidosis and Alzheimer’s Disease |
| title_fullStr | The Role of Inflammatory Cytokines and lncRNAs in the Pathogenesis of Atherosclerosis and Other Inflammatory Diseases: Focus on Sarcoidosis and Alzheimer’s Disease |
| title_full_unstemmed | The Role of Inflammatory Cytokines and lncRNAs in the Pathogenesis of Atherosclerosis and Other Inflammatory Diseases: Focus on Sarcoidosis and Alzheimer’s Disease |
| title_short | The Role of Inflammatory Cytokines and lncRNAs in the Pathogenesis of Atherosclerosis and Other Inflammatory Diseases: Focus on Sarcoidosis and Alzheimer’s Disease |
| title_sort | role of inflammatory cytokines and lncrnas in the pathogenesis of atherosclerosis and other inflammatory diseases focus on sarcoidosis and alzheimer s disease |
| topic | atherosclerosis inflammatory cytokines Alzheimer’s disease sarcoidosis |
| url | https://apcz.umk.pl/QS/article/view/57223 |
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