Influence of a Very High-Molecular Weight Fucoidan from <i>Laminaria hyperborea</i> on Age-Related Macular Degeneration-Relevant Pathomechanisms in Ocular Cell Models

Influence of a Very High-Molecular Weight Fucoidan from <i>Laminaria hyperborea</i> on Age-Related Macular Degeneration-Relevant Pathomechanisms in Ocular Cell Models

Fucoidans from <i>Laminaria hyperborea</i> (LH) can be antioxidative, antiangiogenic, and anti-inflammatory. In this study, a very high-molecular weight (3700 kDa) fucoidan from LH, FucBB04, was tested regarding its bioactivity in age-related macular degeneration (AMD) models <i>in...

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Bibliographic Details
Main Authors: Philipp Dörschmann, Georg Kopplin, Tabea Thalenhorst, Charlotte Seeba, Sadia Fida Ullah, Vaibhav Srivastava, Johann Roider, Alexa Klettner
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Marine Drugs
Subjects:
sulfated fucan
fucoidan
retinal pigment epithelium-specific 65 kDa protein (RPE65)
vascular endothelial growth factor (VEGF)
phagocytosis
gene expression
Online Access:https://www.mdpi.com/1660-3397/23/3/101
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