Helicobacter pylori: pathogenesis
In this review, we analyze the research articles and findings related to the pathogenesis of Helicobacter pylori infection, which were published between April 2023 and March 2024. H. pylori is the most common infectious disease worldwide. The clinical consequences of H. pylori infection are closely...
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| Language: | English |
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Verduci Editore
2024-09-01
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| Series: | Microbiota in Health and Disease |
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| Online Access: | https://www.microbiotajournal.com/wp-content/uploads/sites/7/2024/09/e1046.pdf |
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| _version_ | 1841560902414893056 |
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| author | P. Sabanas L. Jonaitis |
| author_facet | P. Sabanas L. Jonaitis |
| author_sort | P. Sabanas |
| collection | DOAJ |
| description | In this review, we analyze the research articles and findings related to the pathogenesis of Helicobacter pylori infection, which were published between April 2023 and March 2024. H. pylori is the most common infectious disease worldwide. The clinical consequences of H. pylori infection are closely linked with the expression of virulence factors produced by the bacterium. To improve diagnostic tools and optimize the treatment outcomes of H. pylori infection it is essential to understand its pathogenesis. The latest mechanisms of how H. pylori interact with host tissue and microbiome, induces and modulates its pathogenicity, and influences the development of malignant disease as well as extragastric pathologies are represented in our review article. Treatment success rates by the current guidelines-based regimens remain suboptimal due to the increasing antimicrobial resistance of H. pylori. The mechanisms of resistance are still in the scope of research. We also describe the studies related to the possible mechanisms of resistance of H. pylori to antibacterial drugs. |
| format | Article |
| id | doaj-art-82471c72b9e94a40b17cdcfdc060a48d |
| institution | Kabale University |
| issn | 2704-8845 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Verduci Editore |
| record_format | Article |
| series | Microbiota in Health and Disease |
| spelling | doaj-art-82471c72b9e94a40b17cdcfdc060a48d2025-01-03T10:30:12ZengVerduci EditoreMicrobiota in Health and Disease2704-88452024-09-01610.26355/mhd_20249_10461046Helicobacter pylori: pathogenesisP. Sabanas0L. Jonaitis1Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, LithuaniaDepartment of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, LithuaniaIn this review, we analyze the research articles and findings related to the pathogenesis of Helicobacter pylori infection, which were published between April 2023 and March 2024. H. pylori is the most common infectious disease worldwide. The clinical consequences of H. pylori infection are closely linked with the expression of virulence factors produced by the bacterium. To improve diagnostic tools and optimize the treatment outcomes of H. pylori infection it is essential to understand its pathogenesis. The latest mechanisms of how H. pylori interact with host tissue and microbiome, induces and modulates its pathogenicity, and influences the development of malignant disease as well as extragastric pathologies are represented in our review article. Treatment success rates by the current guidelines-based regimens remain suboptimal due to the increasing antimicrobial resistance of H. pylori. The mechanisms of resistance are still in the scope of research. We also describe the studies related to the possible mechanisms of resistance of H. pylori to antibacterial drugs.https://www.microbiotajournal.com/wp-content/uploads/sites/7/2024/09/e1046.pdfhelicobacter pylorih. pyloripathogenesisgastric cancercarcinogenesismicrobiota. |
| spellingShingle | P. Sabanas L. Jonaitis Helicobacter pylori: pathogenesis Microbiota in Health and Disease helicobacter pylori h. pylori pathogenesis gastric cancer carcinogenesis microbiota. |
| title | Helicobacter pylori: pathogenesis |
| title_full | Helicobacter pylori: pathogenesis |
| title_fullStr | Helicobacter pylori: pathogenesis |
| title_full_unstemmed | Helicobacter pylori: pathogenesis |
| title_short | Helicobacter pylori: pathogenesis |
| title_sort | helicobacter pylori pathogenesis |
| topic | helicobacter pylori h. pylori pathogenesis gastric cancer carcinogenesis microbiota. |
| url | https://www.microbiotajournal.com/wp-content/uploads/sites/7/2024/09/e1046.pdf |
| work_keys_str_mv | AT psabanas helicobacterpyloripathogenesis AT ljonaitis helicobacterpyloripathogenesis |