Positive Expression of IGFBP2 as a Novel Prognostic Biomarker for Patients with Lower-Grade Gliomas
Background: Previous studies have identified insulin-like growth factor-binding protein 2 (IGFBP2) as a target gene associated with the prognosis of various malignant cancers. This study aimed to explore the role and mechanisms of this prognostic signature in patients with low-grade gliomas (LGGs).M...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2025-01-01
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| Series: | Middle East Journal of Cancer |
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| Online Access: | https://mejc.sums.ac.ir/article_50116_3fbc062a4e92b1b907d6e5a47ba2f3d1.pdf |
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| author | Yanguo Li Jiawei Fan Zhuo Shen Jun Zhang Xuemei Yin Fang Han Wenfei Li |
| author_facet | Yanguo Li Jiawei Fan Zhuo Shen Jun Zhang Xuemei Yin Fang Han Wenfei Li |
| author_sort | Yanguo Li |
| collection | DOAJ |
| description | Background: Previous studies have identified insulin-like growth factor-binding protein 2 (IGFBP2) as a target gene associated with the prognosis of various malignant cancers. This study aimed to explore the role and mechanisms of this prognostic signature in patients with low-grade gliomas (LGGs).Method: A total of 217 patients with LGGs were retrospectively obtained from the Chinese Glioma Genome Atlas as the training group, whereas an additional 190 cases (GSE107850) were collected from the Gene Expression Omnibus as validation data. The Kaplan–Meier method evaluated the overall survival (OS) between the high IGFBP2 and low IGFBP2 expression groups. Univariate and multivariate Cox analyses were used to identify independent prognostic factors associated with survival. Gene set enrichment analysis (GSEA) was conducted to investigate signaling pathways influencing glioma cell proliferation at the transcriptional level of IGFBP2. Statistical analyses and data visualization were performed using R language (version 3.6.3) and Perl software (version 5.38.1), with significance set at P < 0.05.Results: Kaplan–Meier survival analysis suggested that the group with decreased IGFBP2 expression may have improved OS as compared with the group with high IGFBP2 expression. Increased IGFBP2 expression in gliomas significantly correlated with isocitrate dehydrogenase mutation-wild type. GSEA results revealed that five differential pathways involved in collagen binding, collagen-containing extracellular matrix, collagen metabolic process, collagen trimer, and extracellular structure organization were significantly enriched in patients with glioma with high IGFBP2 expression.Conclusion: Our study is the first to show that overexpression IGFBP2 could be an independent glioma biomarker. For patients with LGG overexpressing IGFBP2, radiotherapy may be a preferable choice over chemotherapy. |
| format | Article |
| id | doaj-art-822bd41635a14089a55e75500fd855df |
| institution | Kabale University |
| issn | 2008-6709 2008-6687 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Middle East Journal of Cancer |
| spelling | doaj-art-822bd41635a14089a55e75500fd855df2025-01-13T05:34:02ZengShiraz University of Medical SciencesMiddle East Journal of Cancer2008-67092008-66872025-01-01161798910.30476/mejc.2024.101125.201450116Positive Expression of IGFBP2 as a Novel Prognostic Biomarker for Patients with Lower-Grade GliomasYanguo Li0Jiawei Fan1Zhuo Shen2Jun Zhang3Xuemei Yin4Fang Han5Wenfei Li6Department of Radiology, First Hospital of Qinhuangdao, Qinhuangdao, Hebei, ChinaDepartment of Radiology, Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Radiology, Tianjin Medical University First Central Clinical College, Tianjin, ChinaDepartment of Radiology, First Hospital of Qinhuangdao, Qinhuangdao, Hebei, ChinaDepartment of Radiology, First Hospital of Qinhuangdao, Qinhuangdao, Hebei, ChinaDepartment of Radiology, Affiliated Zhongshan Hospital of DaLian University, Dalian, Liaoning, ChinaDepartment of Radiology, First Hospital of Qinhuangdao, Qinhuangdao, Hebei, ChinaBackground: Previous studies have identified insulin-like growth factor-binding protein 2 (IGFBP2) as a target gene associated with the prognosis of various malignant cancers. This study aimed to explore the role and mechanisms of this prognostic signature in patients with low-grade gliomas (LGGs).Method: A total of 217 patients with LGGs were retrospectively obtained from the Chinese Glioma Genome Atlas as the training group, whereas an additional 190 cases (GSE107850) were collected from the Gene Expression Omnibus as validation data. The Kaplan–Meier method evaluated the overall survival (OS) between the high IGFBP2 and low IGFBP2 expression groups. Univariate and multivariate Cox analyses were used to identify independent prognostic factors associated with survival. Gene set enrichment analysis (GSEA) was conducted to investigate signaling pathways influencing glioma cell proliferation at the transcriptional level of IGFBP2. Statistical analyses and data visualization were performed using R language (version 3.6.3) and Perl software (version 5.38.1), with significance set at P < 0.05.Results: Kaplan–Meier survival analysis suggested that the group with decreased IGFBP2 expression may have improved OS as compared with the group with high IGFBP2 expression. Increased IGFBP2 expression in gliomas significantly correlated with isocitrate dehydrogenase mutation-wild type. GSEA results revealed that five differential pathways involved in collagen binding, collagen-containing extracellular matrix, collagen metabolic process, collagen trimer, and extracellular structure organization were significantly enriched in patients with glioma with high IGFBP2 expression.Conclusion: Our study is the first to show that overexpression IGFBP2 could be an independent glioma biomarker. For patients with LGG overexpressing IGFBP2, radiotherapy may be a preferable choice over chemotherapy.https://mejc.sums.ac.ir/article_50116_3fbc062a4e92b1b907d6e5a47ba2f3d1.pdfigfbp2gliomaprognosisbioinformaticsgenomics |
| spellingShingle | Yanguo Li Jiawei Fan Zhuo Shen Jun Zhang Xuemei Yin Fang Han Wenfei Li Positive Expression of IGFBP2 as a Novel Prognostic Biomarker for Patients with Lower-Grade Gliomas Middle East Journal of Cancer igfbp2 glioma prognosis bioinformatics genomics |
| title | Positive Expression of IGFBP2 as a Novel Prognostic Biomarker for Patients with Lower-Grade Gliomas |
| title_full | Positive Expression of IGFBP2 as a Novel Prognostic Biomarker for Patients with Lower-Grade Gliomas |
| title_fullStr | Positive Expression of IGFBP2 as a Novel Prognostic Biomarker for Patients with Lower-Grade Gliomas |
| title_full_unstemmed | Positive Expression of IGFBP2 as a Novel Prognostic Biomarker for Patients with Lower-Grade Gliomas |
| title_short | Positive Expression of IGFBP2 as a Novel Prognostic Biomarker for Patients with Lower-Grade Gliomas |
| title_sort | positive expression of igfbp2 as a novel prognostic biomarker for patients with lower grade gliomas |
| topic | igfbp2 glioma prognosis bioinformatics genomics |
| url | https://mejc.sums.ac.ir/article_50116_3fbc062a4e92b1b907d6e5a47ba2f3d1.pdf |
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