Influence of Sodium Alginate on Hypoglycemic Activity of Metformin Hydrochloride in the Microspheres Obtained by the Spray Drying
Alginate microspheres with metformin hydrochloride were prepared by the spray drying method in order to improve residence time of drug in the stomach. Nine formulations (F1–F9) with various drug : polymer ratio (1 : 2, 1 : 1, and 2 : 1) and different sodium alginate concentration (1%, 2%, and 3%) we...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2016/8635408 |
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| author | Marta Szekalska Magdalena Wróblewska Katarzyna Sosnowska Katarzyna Winnicka |
| author_facet | Marta Szekalska Magdalena Wróblewska Katarzyna Sosnowska Katarzyna Winnicka |
| author_sort | Marta Szekalska |
| collection | DOAJ |
| description | Alginate microspheres with metformin hydrochloride were prepared by the spray drying method in order to improve residence time of drug in the stomach. Nine formulations (F1–F9) with various drug : polymer ratio (1 : 2, 1 : 1, and 2 : 1) and different sodium alginate concentration (1%, 2%, and 3%) were evaluated for size, morphology, drug loading, Zeta potential, and swelling degree. In vitro drug release, mathematical release profile, and physical state of microspheres were also evaluated. Optimal formulation characterized by the highest drug loading was formulation F6 (drug : polymer ratio 2 : 1 and 2% alginate solution). Based on glucose uptake in Saccharomyces cerevisiae cells and α-amylase inhibition tests, it could be concluded that alginate microspheres enhance hypoglycemic activity of metformin hydrochloride evaluated in vitro. Designed microspheres are promising as alternative, multicompartment dosage form for metformin hydrochloride delivery. |
| format | Article |
| id | doaj-art-8225855a992843ceac123e2c1c23e5ea |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-8225855a992843ceac123e2c1c23e5ea2025-02-03T01:28:40ZengWileyInternational Journal of Polymer Science1687-94221687-94302016-01-01201610.1155/2016/86354088635408Influence of Sodium Alginate on Hypoglycemic Activity of Metformin Hydrochloride in the Microspheres Obtained by the Spray DryingMarta Szekalska0Magdalena Wróblewska1Katarzyna Sosnowska2Katarzyna Winnicka3Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15-222 Białystok, PolandDepartment of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15-222 Białystok, PolandDepartment of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15-222 Białystok, PolandDepartment of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15-222 Białystok, PolandAlginate microspheres with metformin hydrochloride were prepared by the spray drying method in order to improve residence time of drug in the stomach. Nine formulations (F1–F9) with various drug : polymer ratio (1 : 2, 1 : 1, and 2 : 1) and different sodium alginate concentration (1%, 2%, and 3%) were evaluated for size, morphology, drug loading, Zeta potential, and swelling degree. In vitro drug release, mathematical release profile, and physical state of microspheres were also evaluated. Optimal formulation characterized by the highest drug loading was formulation F6 (drug : polymer ratio 2 : 1 and 2% alginate solution). Based on glucose uptake in Saccharomyces cerevisiae cells and α-amylase inhibition tests, it could be concluded that alginate microspheres enhance hypoglycemic activity of metformin hydrochloride evaluated in vitro. Designed microspheres are promising as alternative, multicompartment dosage form for metformin hydrochloride delivery.http://dx.doi.org/10.1155/2016/8635408 |
| spellingShingle | Marta Szekalska Magdalena Wróblewska Katarzyna Sosnowska Katarzyna Winnicka Influence of Sodium Alginate on Hypoglycemic Activity of Metformin Hydrochloride in the Microspheres Obtained by the Spray Drying International Journal of Polymer Science |
| title | Influence of Sodium Alginate on Hypoglycemic Activity of Metformin Hydrochloride in the Microspheres Obtained by the Spray Drying |
| title_full | Influence of Sodium Alginate on Hypoglycemic Activity of Metformin Hydrochloride in the Microspheres Obtained by the Spray Drying |
| title_fullStr | Influence of Sodium Alginate on Hypoglycemic Activity of Metformin Hydrochloride in the Microspheres Obtained by the Spray Drying |
| title_full_unstemmed | Influence of Sodium Alginate on Hypoglycemic Activity of Metformin Hydrochloride in the Microspheres Obtained by the Spray Drying |
| title_short | Influence of Sodium Alginate on Hypoglycemic Activity of Metformin Hydrochloride in the Microspheres Obtained by the Spray Drying |
| title_sort | influence of sodium alginate on hypoglycemic activity of metformin hydrochloride in the microspheres obtained by the spray drying |
| url | http://dx.doi.org/10.1155/2016/8635408 |
| work_keys_str_mv | AT martaszekalska influenceofsodiumalginateonhypoglycemicactivityofmetforminhydrochlorideinthemicrospheresobtainedbythespraydrying AT magdalenawroblewska influenceofsodiumalginateonhypoglycemicactivityofmetforminhydrochlorideinthemicrospheresobtainedbythespraydrying AT katarzynasosnowska influenceofsodiumalginateonhypoglycemicactivityofmetforminhydrochlorideinthemicrospheresobtainedbythespraydrying AT katarzynawinnicka influenceofsodiumalginateonhypoglycemicactivityofmetforminhydrochlorideinthemicrospheresobtainedbythespraydrying |