Primary Atopic Disorders: Expanding Field of Inborn Errors of Immunity
Inborn errors of immunity cover a broad spectrum of diseases from immune deficiency syndromes to hyperinflammatory conditions. Primary atopic disorders are a recent member of this spectrum as a group that embracing monogenic immune deregulatory diseases causing allergic and atopic phenotypes. Liable...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2024-04-01
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| Series: | Turkish Journal of Immunology |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tji&un=TJI-03779 |
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| author | Güzin Özçifci Sena Nur Arbağ Yasemin Kendir-Demirkol Joshua D Milner |
| author_facet | Güzin Özçifci Sena Nur Arbağ Yasemin Kendir-Demirkol Joshua D Milner |
| author_sort | Güzin Özçifci |
| collection | DOAJ |
| description | Inborn errors of immunity cover a broad spectrum of diseases from immune deficiency syndromes to hyperinflammatory conditions. Primary atopic disorders are a recent member of this spectrum as a group that embracing monogenic immune deregulatory diseases causing allergic and atopic phenotypes. Liable genetic alterations lead to signaling pathways and cellular functioning changes, which skew to type-2 immune responses. Elucidation of these pathways and identifying these disorders have the utmost importance, since early identification of some of these disorders significantly changes the prognosis and targeted treatments offer improved outcomes. In this review, these broad-spectrum of diseases including recent findings were categorized and affected pathways and clinical phenotypes were explained. |
| format | Article |
| id | doaj-art-81e983680aa74d06b6d54733e3b3862a |
| institution | Kabale University |
| issn | 1301-109X 2147-8325 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Immunology |
| spelling | doaj-art-81e983680aa74d06b6d54733e3b3862a2025-01-17T13:55:52ZengGalenos Publishing HouseTurkish Journal of Immunology1301-109X2147-83252024-04-0112Suppl 1607010.4274/tji.galenos.2024.03779TJI-03779Primary Atopic Disorders: Expanding Field of Inborn Errors of ImmunityGüzin Özçifci0Sena Nur Arbağ1Yasemin Kendir-Demirkol2Joshua D Milner3Columbia University Irving Medical Center, Department of Pediatrics, New York, USAColumbia University Irving Medical Center, Department of Pediatrics, New York, USAColumbia University Irving Medical Center, Department of Pediatrics, New York, USAColumbia University Irving Medical Center, Department of Pediatrics, New York, USAInborn errors of immunity cover a broad spectrum of diseases from immune deficiency syndromes to hyperinflammatory conditions. Primary atopic disorders are a recent member of this spectrum as a group that embracing monogenic immune deregulatory diseases causing allergic and atopic phenotypes. Liable genetic alterations lead to signaling pathways and cellular functioning changes, which skew to type-2 immune responses. Elucidation of these pathways and identifying these disorders have the utmost importance, since early identification of some of these disorders significantly changes the prognosis and targeted treatments offer improved outcomes. In this review, these broad-spectrum of diseases including recent findings were categorized and affected pathways and clinical phenotypes were explained.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tji&un=TJI-03779primary atopic disordersfield of inbornimmunity |
| spellingShingle | Güzin Özçifci Sena Nur Arbağ Yasemin Kendir-Demirkol Joshua D Milner Primary Atopic Disorders: Expanding Field of Inborn Errors of Immunity Turkish Journal of Immunology primary atopic disorders field of inborn immunity |
| title | Primary Atopic Disorders: Expanding Field of Inborn Errors of Immunity |
| title_full | Primary Atopic Disorders: Expanding Field of Inborn Errors of Immunity |
| title_fullStr | Primary Atopic Disorders: Expanding Field of Inborn Errors of Immunity |
| title_full_unstemmed | Primary Atopic Disorders: Expanding Field of Inborn Errors of Immunity |
| title_short | Primary Atopic Disorders: Expanding Field of Inborn Errors of Immunity |
| title_sort | primary atopic disorders expanding field of inborn errors of immunity |
| topic | primary atopic disorders field of inborn immunity |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tji&un=TJI-03779 |
| work_keys_str_mv | AT guzinozcifci primaryatopicdisordersexpandingfieldofinbornerrorsofimmunity AT senanurarbag primaryatopicdisordersexpandingfieldofinbornerrorsofimmunity AT yaseminkendirdemirkol primaryatopicdisordersexpandingfieldofinbornerrorsofimmunity AT joshuadmilner primaryatopicdisordersexpandingfieldofinbornerrorsofimmunity |