Case report: Successful therapy with recombinant human vascular endostatin in an elderly man with colon telangiectasia and idiopathic thrombocytopenic purpura
An 83-year-old male presented to our Digestive System Department with a 5-day history of severe gastrointestinal (GI) bleeding and a 14-year history of idiopathic thrombocytopenic purpura (ITP) with low platelet levels. Colonoscopy revealed extensive telangiectasias throughout the colon, particularl...
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Frontiers Media S.A.
2025-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1511513/full |
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| author | Yushan Wu Yushan Wu Yushan Wu Yongbin Jia Mingshan Jiang Mingshan Jiang Mingshan Jiang Hu Zhang Hu Zhang Hu Zhang |
| author_facet | Yushan Wu Yushan Wu Yushan Wu Yongbin Jia Mingshan Jiang Mingshan Jiang Mingshan Jiang Hu Zhang Hu Zhang Hu Zhang |
| author_sort | Yushan Wu |
| collection | DOAJ |
| description | An 83-year-old male presented to our Digestive System Department with a 5-day history of severe gastrointestinal (GI) bleeding and a 14-year history of idiopathic thrombocytopenic purpura (ITP) with low platelet levels. Colonoscopy revealed extensive telangiectasias throughout the colon, particularly in the transverse and ascending segments. Standard treatment with proton-pump inhibitors and somatostatin proved ineffective. Additionally, conventional therapies such as estrogen and thalidomide were contraindicated due to the comorbidity of ITP. Endoscopic hemostasis was also difficult to perform because of the widespread nature of the lesions. However, after the innovative use of four courses of recombinant human vascular endostatin (Endostar) therapy, the colon telangiectasia was completely resolved, and the patient reported no GI bleeding for 2 years. Managing severe GI bleeding with a rare etiology is particularly challenging, especially in patients with contraindications to conventional treatments due to comorbidities. In this case, a vascular endothelial growth factor (VEGF) inhibitor was successfully applied to treat a refractory and rare GI bleeding, which may offer a novel therapeutic approach for similar cases. |
| format | Article |
| id | doaj-art-81cb73e0217941cc910ebf3efcb52148 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-81cb73e0217941cc910ebf3efcb521482025-01-15T06:10:31ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.15115131511513Case report: Successful therapy with recombinant human vascular endostatin in an elderly man with colon telangiectasia and idiopathic thrombocytopenic purpuraYushan Wu0Yushan Wu1Yushan Wu2Yongbin Jia3Mingshan Jiang4Mingshan Jiang5Mingshan Jiang6Hu Zhang7Hu Zhang8Hu Zhang9Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, ChinaCentre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, ChinaLab of Inflammatory Bowel Disease, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaLab of Inflammatory Bowel Disease, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Gastroenterology, West China Hospital, Sichuan University, Chengdu, ChinaCentre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, ChinaLab of Inflammatory Bowel Disease, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Gastroenterology, West China Hospital, Sichuan University, Chengdu, ChinaCentre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, ChinaLab of Inflammatory Bowel Disease, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaAn 83-year-old male presented to our Digestive System Department with a 5-day history of severe gastrointestinal (GI) bleeding and a 14-year history of idiopathic thrombocytopenic purpura (ITP) with low platelet levels. Colonoscopy revealed extensive telangiectasias throughout the colon, particularly in the transverse and ascending segments. Standard treatment with proton-pump inhibitors and somatostatin proved ineffective. Additionally, conventional therapies such as estrogen and thalidomide were contraindicated due to the comorbidity of ITP. Endoscopic hemostasis was also difficult to perform because of the widespread nature of the lesions. However, after the innovative use of four courses of recombinant human vascular endostatin (Endostar) therapy, the colon telangiectasia was completely resolved, and the patient reported no GI bleeding for 2 years. Managing severe GI bleeding with a rare etiology is particularly challenging, especially in patients with contraindications to conventional treatments due to comorbidities. In this case, a vascular endothelial growth factor (VEGF) inhibitor was successfully applied to treat a refractory and rare GI bleeding, which may offer a novel therapeutic approach for similar cases.https://www.frontiersin.org/articles/10.3389/fmed.2024.1511513/fullgastrointestinal bleedingtelangiectasiacolonidiopathic thrombocytopenic purpurarecombinant human vascular endostatinvascular endothelial growth factor |
| spellingShingle | Yushan Wu Yushan Wu Yushan Wu Yongbin Jia Mingshan Jiang Mingshan Jiang Mingshan Jiang Hu Zhang Hu Zhang Hu Zhang Case report: Successful therapy with recombinant human vascular endostatin in an elderly man with colon telangiectasia and idiopathic thrombocytopenic purpura Frontiers in Medicine gastrointestinal bleeding telangiectasia colon idiopathic thrombocytopenic purpura recombinant human vascular endostatin vascular endothelial growth factor |
| title | Case report: Successful therapy with recombinant human vascular endostatin in an elderly man with colon telangiectasia and idiopathic thrombocytopenic purpura |
| title_full | Case report: Successful therapy with recombinant human vascular endostatin in an elderly man with colon telangiectasia and idiopathic thrombocytopenic purpura |
| title_fullStr | Case report: Successful therapy with recombinant human vascular endostatin in an elderly man with colon telangiectasia and idiopathic thrombocytopenic purpura |
| title_full_unstemmed | Case report: Successful therapy with recombinant human vascular endostatin in an elderly man with colon telangiectasia and idiopathic thrombocytopenic purpura |
| title_short | Case report: Successful therapy with recombinant human vascular endostatin in an elderly man with colon telangiectasia and idiopathic thrombocytopenic purpura |
| title_sort | case report successful therapy with recombinant human vascular endostatin in an elderly man with colon telangiectasia and idiopathic thrombocytopenic purpura |
| topic | gastrointestinal bleeding telangiectasia colon idiopathic thrombocytopenic purpura recombinant human vascular endostatin vascular endothelial growth factor |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1511513/full |
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