Exploring the influence of pre-analytical variables on gene expression measurements and relative expression orderings in cancer research

Exploring the influence of pre-analytical variables on gene expression measurements and relative expression orderings in cancer research

Abstract Gene expression profiling is an effective method for identifying predictive and prognostic biomarkers. However, measurements are prone to uncertainty and errors due to various pre-analytical variables. Systematic evaluating effects of these variables on gene expression measurements and rela...

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Bibliographic Details
Main Authors: Tian Tian, Guie Lai, Ming He, Xiaofang Liu, Yun Luo, You Guo, Guini Hong, Hongdong Li, Kai Song, Hao Cai
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Relative expression orderings
Gene expression
Pre-analytical variables
Biomarker
Robustness
Measurement variation
Online Access:https://doi.org/10.1038/s41598-025-88756-0
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