Cytotoxicity of Alkyl Derivatives of Protocetraric Acid
The protocetraric acid (1) is a depsidone produced by countless species of lichens and has shown potential biological activity. In this work, we evaluated through the sulforhodamine B (SRB) assay the cytotoxic activity of seven alkyl ether derivatives of protocetraric acid (9´-O-alkyl protocetraric...
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| Format: | Article |
| Language: | English |
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Universidade Federal de Mato Grosso do Sul
2025-01-01
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| Series: | Orbital: The Electronic Journal of Chemistry |
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| Online Access: | https://periodicos.ufms.br/index.php/orbital/article/view/21887 |
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| author | Danielle Bogo Glaucia Alcantara Ana Camila Micheletti Neli Honda Maria de Fátima Cepa Matos |
| author_facet | Danielle Bogo Glaucia Alcantara Ana Camila Micheletti Neli Honda Maria de Fátima Cepa Matos |
| author_sort | Danielle Bogo |
| collection | DOAJ |
| description |
The protocetraric acid (1) is a depsidone produced by countless species of lichens and has shown potential biological activity. In this work, we evaluated through the sulforhodamine B (SRB) assay the cytotoxic activity of seven alkyl ether derivatives of protocetraric acid (9´-O-alkyl protocetraric acid) against the following cell lines: HT-29 (colon carcinoma), 786-0 (kidney carcinoma), MCF7 (breast carcinoma), HEP2 (laryngeal carcinoma), PC-03 (prostate carcinoma), B16F10 (murine melanoma), UACC-62 (human melanoma), and NIH/3T3 (mouse embryonic fibroblast). Most compounds were cytotoxic to tested cells, with GI50 < 100.0 μM, and did not show selectivity over them.
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| format | Article |
| id | doaj-art-8195c56772f14b67ad7ebaeed4e34d12 |
| institution | Kabale University |
| issn | 1984-6428 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Universidade Federal de Mato Grosso do Sul |
| record_format | Article |
| series | Orbital: The Electronic Journal of Chemistry |
| spelling | doaj-art-8195c56772f14b67ad7ebaeed4e34d122025-01-11T14:34:05ZengUniversidade Federal de Mato Grosso do SulOrbital: The Electronic Journal of Chemistry1984-64282025-01-0116410.17807/orbital.v16i4.21887Cytotoxicity of Alkyl Derivatives of Protocetraric AcidDanielle Bogo0Glaucia Alcantara1Ana Camila Micheletti2Neli Honda3Maria de Fátima Cepa Matos4UFMSUFMSDepartment of Chemistry, UFMSUFMSUFMS The protocetraric acid (1) is a depsidone produced by countless species of lichens and has shown potential biological activity. In this work, we evaluated through the sulforhodamine B (SRB) assay the cytotoxic activity of seven alkyl ether derivatives of protocetraric acid (9´-O-alkyl protocetraric acid) against the following cell lines: HT-29 (colon carcinoma), 786-0 (kidney carcinoma), MCF7 (breast carcinoma), HEP2 (laryngeal carcinoma), PC-03 (prostate carcinoma), B16F10 (murine melanoma), UACC-62 (human melanoma), and NIH/3T3 (mouse embryonic fibroblast). Most compounds were cytotoxic to tested cells, with GI50 < 100.0 μM, and did not show selectivity over them. https://periodicos.ufms.br/index.php/orbital/article/view/21887alkyl derivativesdepsidonelichensprotocetraric acidtoxicitytumor cells |
| spellingShingle | Danielle Bogo Glaucia Alcantara Ana Camila Micheletti Neli Honda Maria de Fátima Cepa Matos Cytotoxicity of Alkyl Derivatives of Protocetraric Acid Orbital: The Electronic Journal of Chemistry alkyl derivatives depsidone lichens protocetraric acid toxicity tumor cells |
| title | Cytotoxicity of Alkyl Derivatives of Protocetraric Acid |
| title_full | Cytotoxicity of Alkyl Derivatives of Protocetraric Acid |
| title_fullStr | Cytotoxicity of Alkyl Derivatives of Protocetraric Acid |
| title_full_unstemmed | Cytotoxicity of Alkyl Derivatives of Protocetraric Acid |
| title_short | Cytotoxicity of Alkyl Derivatives of Protocetraric Acid |
| title_sort | cytotoxicity of alkyl derivatives of protocetraric acid |
| topic | alkyl derivatives depsidone lichens protocetraric acid toxicity tumor cells |
| url | https://periodicos.ufms.br/index.php/orbital/article/view/21887 |
| work_keys_str_mv | AT daniellebogo cytotoxicityofalkylderivativesofprotocetraricacid AT glauciaalcantara cytotoxicityofalkylderivativesofprotocetraricacid AT anacamilamicheletti cytotoxicityofalkylderivativesofprotocetraricacid AT nelihonda cytotoxicityofalkylderivativesofprotocetraricacid AT mariadefatimacepamatos cytotoxicityofalkylderivativesofprotocetraricacid |