Reconstructing the last common ancestor of all eukaryotes.
Understanding the origin of eukaryotic cells is one of the most difficult problems in all of biology. A key challenge relevant to the question of eukaryogenesis is reconstructing the gene repertoire of the last eukaryotic common ancestor (LECA). As data sets grow, sketching an accurate genomics-info...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-11-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3002917 |
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| author | Thomas A Richards Laura Eme John M Archibald Guy Leonard Susana M Coelho Alex de Mendoza Christophe Dessimoz Pavel Dolezal Lillian K Fritz-Laylin Toni Gabaldón Vladimír Hampl Geert J P L Kops Michelle M Leger Purificacion Lopez-Garcia James O McInerney David Moreira Sergio A Muñoz-Gómez Daniel J Richter Iñaki Ruiz-Trillo Alyson E Santoro Arnau Sebé-Pedrós Berend Snel Courtney W Stairs Eelco C Tromer Jolien J E van Hooff Bill Wickstead Tom A Williams Andrew J Roger Joel B Dacks Jeremy G Wideman |
| author_facet | Thomas A Richards Laura Eme John M Archibald Guy Leonard Susana M Coelho Alex de Mendoza Christophe Dessimoz Pavel Dolezal Lillian K Fritz-Laylin Toni Gabaldón Vladimír Hampl Geert J P L Kops Michelle M Leger Purificacion Lopez-Garcia James O McInerney David Moreira Sergio A Muñoz-Gómez Daniel J Richter Iñaki Ruiz-Trillo Alyson E Santoro Arnau Sebé-Pedrós Berend Snel Courtney W Stairs Eelco C Tromer Jolien J E van Hooff Bill Wickstead Tom A Williams Andrew J Roger Joel B Dacks Jeremy G Wideman |
| author_sort | Thomas A Richards |
| collection | DOAJ |
| description | Understanding the origin of eukaryotic cells is one of the most difficult problems in all of biology. A key challenge relevant to the question of eukaryogenesis is reconstructing the gene repertoire of the last eukaryotic common ancestor (LECA). As data sets grow, sketching an accurate genomics-informed picture of early eukaryotic cellular complexity requires provision of analytical resources and a commitment to data sharing. Here, we summarise progress towards understanding the biology of LECA and outline a community approach to inferring its wider gene repertoire. Once assembled, a robust LECA gene set will be a useful tool for evaluating alternative hypotheses about the origin of eukaryotes and understanding the evolution of traits in all descendant lineages, with relevance in diverse fields such as cell biology, microbial ecology, biotechnology, agriculture, and medicine. In this Consensus View, we put forth the status quo and an agreed path forward to reconstruct LECA's gene content. |
| format | Article |
| id | doaj-art-81517f9828814b7fb85e2a6a375c29e7 |
| institution | Kabale University |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-81517f9828814b7fb85e2a6a375c29e72025-01-17T05:30:43ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852024-11-012211e300291710.1371/journal.pbio.3002917Reconstructing the last common ancestor of all eukaryotes.Thomas A RichardsLaura EmeJohn M ArchibaldGuy LeonardSusana M CoelhoAlex de MendozaChristophe DessimozPavel DolezalLillian K Fritz-LaylinToni GabaldónVladimír HamplGeert J P L KopsMichelle M LegerPurificacion Lopez-GarciaJames O McInerneyDavid MoreiraSergio A Muñoz-GómezDaniel J RichterIñaki Ruiz-TrilloAlyson E SantoroArnau Sebé-PedrósBerend SnelCourtney W StairsEelco C TromerJolien J E van HooffBill WicksteadTom A WilliamsAndrew J RogerJoel B DacksJeremy G WidemanUnderstanding the origin of eukaryotic cells is one of the most difficult problems in all of biology. A key challenge relevant to the question of eukaryogenesis is reconstructing the gene repertoire of the last eukaryotic common ancestor (LECA). As data sets grow, sketching an accurate genomics-informed picture of early eukaryotic cellular complexity requires provision of analytical resources and a commitment to data sharing. Here, we summarise progress towards understanding the biology of LECA and outline a community approach to inferring its wider gene repertoire. Once assembled, a robust LECA gene set will be a useful tool for evaluating alternative hypotheses about the origin of eukaryotes and understanding the evolution of traits in all descendant lineages, with relevance in diverse fields such as cell biology, microbial ecology, biotechnology, agriculture, and medicine. In this Consensus View, we put forth the status quo and an agreed path forward to reconstruct LECA's gene content.https://doi.org/10.1371/journal.pbio.3002917 |
| spellingShingle | Thomas A Richards Laura Eme John M Archibald Guy Leonard Susana M Coelho Alex de Mendoza Christophe Dessimoz Pavel Dolezal Lillian K Fritz-Laylin Toni Gabaldón Vladimír Hampl Geert J P L Kops Michelle M Leger Purificacion Lopez-Garcia James O McInerney David Moreira Sergio A Muñoz-Gómez Daniel J Richter Iñaki Ruiz-Trillo Alyson E Santoro Arnau Sebé-Pedrós Berend Snel Courtney W Stairs Eelco C Tromer Jolien J E van Hooff Bill Wickstead Tom A Williams Andrew J Roger Joel B Dacks Jeremy G Wideman Reconstructing the last common ancestor of all eukaryotes. PLoS Biology |
| title | Reconstructing the last common ancestor of all eukaryotes. |
| title_full | Reconstructing the last common ancestor of all eukaryotes. |
| title_fullStr | Reconstructing the last common ancestor of all eukaryotes. |
| title_full_unstemmed | Reconstructing the last common ancestor of all eukaryotes. |
| title_short | Reconstructing the last common ancestor of all eukaryotes. |
| title_sort | reconstructing the last common ancestor of all eukaryotes |
| url | https://doi.org/10.1371/journal.pbio.3002917 |
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