Respiratory Syncytial Virus Infections in Pediatric Intensive Care: Association of Sociodemographic Data and Clinical Outcomes with Viral and Bacterial Co-infections
Objective: The aim of the study was to evaluate respiratory syncytial virus (RSV) infections in cases followed in the pediatric intensive care unit (PICU). Materials and Methods: The study was designed as a prospective cohort in 6 PICUs. There were 3 groups: only RSV (+), RSV (v+) who were posit...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
AVES Yayincilik
2024-09-01
|
| Series: | Turkish Archives of Pediatrics |
| Online Access: | https://turkarchpediatr.org/en/respiratory-syncytial-virus-infections-in-pediatric-intensive-care-association-of-sociodemographic-data-and-clinical-outcomes-with-viral-and-bacterial-co-infections-131696 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846150903989534720 |
|---|---|
| author | Ülkem Koçoğlu Barlas Nihal Akçay Leyla Telhan Murat Kanğın Özge Umur Agop Çıtak Hazal Ceren Tuğrul Seher Erdoğan Mehmet Emin Menentoğlu Esra Şevketoğlu Muhterem Duyu Kübra Boydağ Güvenç Yaşar Yusuf Can Batuhan Türkoğlu |
| author_facet | Ülkem Koçoğlu Barlas Nihal Akçay Leyla Telhan Murat Kanğın Özge Umur Agop Çıtak Hazal Ceren Tuğrul Seher Erdoğan Mehmet Emin Menentoğlu Esra Şevketoğlu Muhterem Duyu Kübra Boydağ Güvenç Yaşar Yusuf Can Batuhan Türkoğlu |
| author_sort | Ülkem Koçoğlu Barlas |
| collection | DOAJ |
| description | Objective: The aim of the study was to evaluate respiratory syncytial virus (RSV) infections in cases followed in the pediatric intensive care unit (PICU).
Materials and Methods: The study was designed as a prospective cohort in 6 PICUs. There were 3 groups: only RSV (+), RSV (v+) who were positive for another viral agent(s) in addition to RSV, and RSV (b+) who were positive for a bacterial agent(s) in addition to RSV.
Results: A total of 119 cases were included in the study, 67 (56.3%) of whom were male. The RSV (+) group had a lower pH compared to the other groups and a higher rate of acute bronc hiolitis/bronchitis diagnoses compared to the RSV (v+) group. The RSV (v+) group had higher bicarbonate levels, higher creatinine levels, longer hospital stays, and higher Pediatric Risk of Mortality-3 scores (PRISM-3) compared to the RSV (+) group. Cases with RSV (b+) were younger and also had lower body weight compared to the other groups. Furthermore, the RSV (b+) group had higher C-reactive protein and Procalcitonin (PCT) levels and higher rates of
High Flow Nasal Cannula-Oxygen Therapy (HFNC-OT) use. Multiple linear regression analysis revealed that PRISM-3 score, PCT levels, Pediatric Acute Respiratory Distress Syndrome diagnoses, inhaled steroid use, chronic illness status, and heart rate on admission were associated with the length of stay in the PICU.
Conclusion:High flow nasal cannula-oxygen therapy continues to be the most frequently preferred respiratory support method in RSV infections. Viral infections accompanying RSV can increase the severity of the disease.
|
| format | Article |
| id | doaj-art-8137efad452543b1b86ab99e019a3a52 |
| institution | Kabale University |
| issn | 2757-6256 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | AVES Yayincilik |
| record_format | Article |
| series | Turkish Archives of Pediatrics |
| spelling | doaj-art-8137efad452543b1b86ab99e019a3a522024-11-28T07:10:34ZengAVES YayincilikTurkish Archives of Pediatrics2757-62562024-09-0159549450010.5152/TurkArchPediatr.2024.24149Respiratory Syncytial Virus Infections in Pediatric Intensive Care: Association of Sociodemographic Data and Clinical Outcomes with Viral and Bacterial Co-infectionsÜlkem Koçoğlu Barlas0Nihal Akçay1Leyla Telhan2Murat Kanğın3Özge Umur4Agop Çıtak5Hazal Ceren Tuğrul6Seher Erdoğan7Mehmet Emin Menentoğlu8Esra Şevketoğlu9Muhterem Duyu10Kübra Boydağ Güvenç11Yaşar Yusuf Can12Batuhan Türkoğlu13Department of Pediatrics, Pediatric Intensivist, Istanbul Medeniyet University Faculty of Medicine, Goztepe Prof Dr Suleyman Yalcın City Hospital, Pediatric Intensive Care Unit, İstanbul, TürkiyeDepartment of Pediatrics, University of Health Sciences Türkiye, Kanuni Sultan Suleyman Training and Research Hospital, Pediatric Intensive Care Unit, İstanbul, TürkiyePediatric Intensivist, Istanbul Medipol University, Bagcilar Mega Hospital, Pediatric Intensive Care Unit, İstanbul, TürkiyePediatric Intensivist, Istanbul Medipol University, Bagcilar Mega Hospital, Pediatric Intensive Care Unit, İstanbul, TürkiyePediatric Intensivist, Acıbadem Mehmet Ali Aydınlar University, Atakent Hospital, Pediatric Intensive Care Unit, İstanbul, TürkiyePediatric Intensivist, Acıbadem Mehmet Ali Aydınlar University, Atakent Hospital, Pediatric Intensive Care Unit, İstanbul, TürkiyeDepartment of Pediatrics, Fellow of Pediatric Intensive Care, University of Health Sciences Türkiye, Umraniye Training and Research Hospital, Pediatric Intensive Care Unit, İstanbul, TürkiyeDepartment of Pediatrics, Fellow of Pediatric Intensive Care, University of Health Sciences Türkiye, Umraniye Training and Research Hospital, Pediatric Intensive Care Unit, İstanbul, TürkiyeDepartment of Pediatric Intensive Care, Pediatric Intensivist, University of Health Sciences Türkiye, Bakirkoy Dr Sadi Konuk Training and Research Hospital, İstanbul, TürkiyeDepartment of Pediatric Intensive Care, Pediatric Intensivist, University of Health Sciences Türkiye, Bakirkoy Dr Sadi Konuk Training and Research Hospital, İstanbul, TürkiyeAssociated Professor of Pediatric Intensive Care, Goztepe Prof Dr Suleyman Yalcın City Hospital, Pediatric Intensive Care Unit, İstanbul, TürkiyeDepartment of Pediatrics, Pediatric Intensivist, University of Health Sciences Türkiye, Sancaktepe Sehit Prof Dr Ilhan Varank Training and Research Hospital, Pediatric Intensive Care Unit, İstanbul, TürkiyeDepartment of Pediatrics, Pediatric Intensivist, University of Health Sciences Türkiye, Sancaktepe Sehit Prof Dr Ilhan Varank Training and Research Hospital, Pediatric Intensive Care Unit, İstanbul, TürkiyeDepartment of Pediatrics, University of Health Sciences Türkiye, Kanuni Sultan Suleyman Training and Research Hospital, Pediatric Intensive Care Unit, İstanbul, TürkiyeObjective: The aim of the study was to evaluate respiratory syncytial virus (RSV) infections in cases followed in the pediatric intensive care unit (PICU). Materials and Methods: The study was designed as a prospective cohort in 6 PICUs. There were 3 groups: only RSV (+), RSV (v+) who were positive for another viral agent(s) in addition to RSV, and RSV (b+) who were positive for a bacterial agent(s) in addition to RSV. Results: A total of 119 cases were included in the study, 67 (56.3%) of whom were male. The RSV (+) group had a lower pH compared to the other groups and a higher rate of acute bronc hiolitis/bronchitis diagnoses compared to the RSV (v+) group. The RSV (v+) group had higher bicarbonate levels, higher creatinine levels, longer hospital stays, and higher Pediatric Risk of Mortality-3 scores (PRISM-3) compared to the RSV (+) group. Cases with RSV (b+) were younger and also had lower body weight compared to the other groups. Furthermore, the RSV (b+) group had higher C-reactive protein and Procalcitonin (PCT) levels and higher rates of High Flow Nasal Cannula-Oxygen Therapy (HFNC-OT) use. Multiple linear regression analysis revealed that PRISM-3 score, PCT levels, Pediatric Acute Respiratory Distress Syndrome diagnoses, inhaled steroid use, chronic illness status, and heart rate on admission were associated with the length of stay in the PICU. Conclusion:High flow nasal cannula-oxygen therapy continues to be the most frequently preferred respiratory support method in RSV infections. Viral infections accompanying RSV can increase the severity of the disease. https://turkarchpediatr.org/en/respiratory-syncytial-virus-infections-in-pediatric-intensive-care-association-of-sociodemographic-data-and-clinical-outcomes-with-viral-and-bacterial-co-infections-131696 |
| spellingShingle | Ülkem Koçoğlu Barlas Nihal Akçay Leyla Telhan Murat Kanğın Özge Umur Agop Çıtak Hazal Ceren Tuğrul Seher Erdoğan Mehmet Emin Menentoğlu Esra Şevketoğlu Muhterem Duyu Kübra Boydağ Güvenç Yaşar Yusuf Can Batuhan Türkoğlu Respiratory Syncytial Virus Infections in Pediatric Intensive Care: Association of Sociodemographic Data and Clinical Outcomes with Viral and Bacterial Co-infections Turkish Archives of Pediatrics |
| title | Respiratory Syncytial Virus Infections in Pediatric Intensive Care: Association of Sociodemographic Data and Clinical Outcomes with Viral and Bacterial Co-infections |
| title_full | Respiratory Syncytial Virus Infections in Pediatric Intensive Care: Association of Sociodemographic Data and Clinical Outcomes with Viral and Bacterial Co-infections |
| title_fullStr | Respiratory Syncytial Virus Infections in Pediatric Intensive Care: Association of Sociodemographic Data and Clinical Outcomes with Viral and Bacterial Co-infections |
| title_full_unstemmed | Respiratory Syncytial Virus Infections in Pediatric Intensive Care: Association of Sociodemographic Data and Clinical Outcomes with Viral and Bacterial Co-infections |
| title_short | Respiratory Syncytial Virus Infections in Pediatric Intensive Care: Association of Sociodemographic Data and Clinical Outcomes with Viral and Bacterial Co-infections |
| title_sort | respiratory syncytial virus infections in pediatric intensive care association of sociodemographic data and clinical outcomes with viral and bacterial co infections |
| url | https://turkarchpediatr.org/en/respiratory-syncytial-virus-infections-in-pediatric-intensive-care-association-of-sociodemographic-data-and-clinical-outcomes-with-viral-and-bacterial-co-infections-131696 |
| work_keys_str_mv | AT ulkemkocoglubarlas respiratorysyncytialvirusinfectionsinpediatricintensivecareassociationofsociodemographicdataandclinicaloutcomeswithviralandbacterialcoinfections AT nihalakcay respiratorysyncytialvirusinfectionsinpediatricintensivecareassociationofsociodemographicdataandclinicaloutcomeswithviralandbacterialcoinfections AT leylatelhan respiratorysyncytialvirusinfectionsinpediatricintensivecareassociationofsociodemographicdataandclinicaloutcomeswithviralandbacterialcoinfections AT muratkangın respiratorysyncytialvirusinfectionsinpediatricintensivecareassociationofsociodemographicdataandclinicaloutcomeswithviralandbacterialcoinfections AT ozgeumur respiratorysyncytialvirusinfectionsinpediatricintensivecareassociationofsociodemographicdataandclinicaloutcomeswithviralandbacterialcoinfections AT agopcıtak respiratorysyncytialvirusinfectionsinpediatricintensivecareassociationofsociodemographicdataandclinicaloutcomeswithviralandbacterialcoinfections AT hazalcerentugrul respiratorysyncytialvirusinfectionsinpediatricintensivecareassociationofsociodemographicdataandclinicaloutcomeswithviralandbacterialcoinfections AT sehererdogan respiratorysyncytialvirusinfectionsinpediatricintensivecareassociationofsociodemographicdataandclinicaloutcomeswithviralandbacterialcoinfections AT mehmeteminmenentoglu respiratorysyncytialvirusinfectionsinpediatricintensivecareassociationofsociodemographicdataandclinicaloutcomeswithviralandbacterialcoinfections AT esrasevketoglu respiratorysyncytialvirusinfectionsinpediatricintensivecareassociationofsociodemographicdataandclinicaloutcomeswithviralandbacterialcoinfections AT muhteremduyu respiratorysyncytialvirusinfectionsinpediatricintensivecareassociationofsociodemographicdataandclinicaloutcomeswithviralandbacterialcoinfections AT kubraboydagguvenc respiratorysyncytialvirusinfectionsinpediatricintensivecareassociationofsociodemographicdataandclinicaloutcomeswithviralandbacterialcoinfections AT yasaryusufcan respiratorysyncytialvirusinfectionsinpediatricintensivecareassociationofsociodemographicdataandclinicaloutcomeswithviralandbacterialcoinfections AT batuhanturkoglu respiratorysyncytialvirusinfectionsinpediatricintensivecareassociationofsociodemographicdataandclinicaloutcomeswithviralandbacterialcoinfections |