Neonatal Screening for Congenital Hypothyroidism: A Study Conducted in a Tertiary Care Hospital of Gujarat
Background: Growth and differentiation of the fetal brain largely depend on the thyroidal biochemical cascade. The most common cause of congenital hypothyroidism (CH) is thyroid dysgenesis. Maternal iodine deficiency remains to be the predominant cause of underactive thyroid in neonates. Congenital...
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Jaypee Brothers Medical Publisher
2024-04-01
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| Series: | Indian Journal of Medical Biochemistry |
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| Online Access: | https://www.ijmb.in/doi/IJMB/pdf/10.5005/jp-journals-10054-0229 |
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| author | Shubhangi Rathod Ramesh Pradhan Rosy Lekharu Jaydip Vala Mehak Kulshrestha |
| author_facet | Shubhangi Rathod Ramesh Pradhan Rosy Lekharu Jaydip Vala Mehak Kulshrestha |
| author_sort | Shubhangi Rathod |
| collection | DOAJ |
| description | Background: Growth and differentiation of the fetal brain largely depend on the thyroidal biochemical cascade. The most common cause of congenital hypothyroidism (CH) is thyroid dysgenesis. Maternal iodine deficiency remains to be the predominant cause of underactive thyroid in neonates. Congenital hypothyroidism fulfils Wilson and Jungners criteria for newborn screening, in having a suitable test, and treatment and that the costs of screening, confirmation, and treatment are balanced against the overall costs of not screening.
Aims and objectives:
Aims: Assessment of possible methods for screening/early detection of CH in neonates.
Primary objective: Compare and correlate cord blood (CB) thyroid stimulating hormone (TSH) with heel prick TSH, as a marker of CH.
Materials and methods: In a prospective study approved by the Ethical Committee of GCS Medical College and Hospital, Ahmedabad, 100 neonates (50 males and 50 females) were assessed for thyroid status after excluding those born of known hypothyroid mothers or having a history of distress. Cord blood was collected at the time of delivery, and dried blood spots (DBS) from heel prick at 72 hours were collected and TSH was compared.
Results: The findings were comparable in both samples as mean TSH CB = 6.14 ± 2.82 mIU/L vs mean TSH DBS = 6.21 ± 3.03 mIU/L; <i>p</i>-value = 0.9268 at 95% confidence interval and <i>r</i>-value for TSH = 0.9783. This was true in normal delivery as well as LSCS births. |
| format | Article |
| id | doaj-art-80c3afccb6d84103a8ab7fbb87cc477c |
| institution | Kabale University |
| issn | 2456-5164 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Jaypee Brothers Medical Publisher |
| record_format | Article |
| series | Indian Journal of Medical Biochemistry |
| spelling | doaj-art-80c3afccb6d84103a8ab7fbb87cc477c2025-01-03T07:48:11ZengJaypee Brothers Medical PublisherIndian Journal of Medical Biochemistry2456-51642024-04-0128112010.5005/jp-journals-10054-02291Neonatal Screening for Congenital Hypothyroidism: A Study Conducted in a Tertiary Care Hospital of GujaratShubhangi Rathod0Ramesh Pradhan1Rosy Lekharu2Jaydip Vala3Mehak Kulshrestha4Shubhangi Rathod, Department of Biochemistry, GCS Medical College, Hospital and Research Centre, Ahmedabad, Gujarat, India, Phone: +91 9429882792Department of Biochemistry, GCS Medical College, Hospital and Research Centre, Ahmedabad, Gujarat, IndiaDepartment of Biochemistry, GCS Medical College, Hospital and Research Centre, Ahmedabad, Gujarat, IndiaDepartment of Biochemistry, GCS Medical College, Hospital and Research Centre, Ahmedabad, Gujarat, IndiaDepartment of Biochemistry, GCS Medical College, Hospital and Research Centre, Ahmedabad, Gujarat, IndiaBackground: Growth and differentiation of the fetal brain largely depend on the thyroidal biochemical cascade. The most common cause of congenital hypothyroidism (CH) is thyroid dysgenesis. Maternal iodine deficiency remains to be the predominant cause of underactive thyroid in neonates. Congenital hypothyroidism fulfils Wilson and Jungners criteria for newborn screening, in having a suitable test, and treatment and that the costs of screening, confirmation, and treatment are balanced against the overall costs of not screening. Aims and objectives: Aims: Assessment of possible methods for screening/early detection of CH in neonates. Primary objective: Compare and correlate cord blood (CB) thyroid stimulating hormone (TSH) with heel prick TSH, as a marker of CH. Materials and methods: In a prospective study approved by the Ethical Committee of GCS Medical College and Hospital, Ahmedabad, 100 neonates (50 males and 50 females) were assessed for thyroid status after excluding those born of known hypothyroid mothers or having a history of distress. Cord blood was collected at the time of delivery, and dried blood spots (DBS) from heel prick at 72 hours were collected and TSH was compared. Results: The findings were comparable in both samples as mean TSH CB = 6.14 ± 2.82 mIU/L vs mean TSH DBS = 6.21 ± 3.03 mIU/L; <i>p</i>-value = 0.9268 at 95% confidence interval and <i>r</i>-value for TSH = 0.9783. This was true in normal delivery as well as LSCS births.https://www.ijmb.in/doi/IJMB/pdf/10.5005/jp-journals-10054-0229congenital hypothyroidismneonatal screeningthyroid stimulating hormone |
| spellingShingle | Shubhangi Rathod Ramesh Pradhan Rosy Lekharu Jaydip Vala Mehak Kulshrestha Neonatal Screening for Congenital Hypothyroidism: A Study Conducted in a Tertiary Care Hospital of Gujarat Indian Journal of Medical Biochemistry congenital hypothyroidism neonatal screening thyroid stimulating hormone |
| title | Neonatal Screening for Congenital Hypothyroidism: A Study Conducted in a Tertiary Care Hospital of Gujarat |
| title_full | Neonatal Screening for Congenital Hypothyroidism: A Study Conducted in a Tertiary Care Hospital of Gujarat |
| title_fullStr | Neonatal Screening for Congenital Hypothyroidism: A Study Conducted in a Tertiary Care Hospital of Gujarat |
| title_full_unstemmed | Neonatal Screening for Congenital Hypothyroidism: A Study Conducted in a Tertiary Care Hospital of Gujarat |
| title_short | Neonatal Screening for Congenital Hypothyroidism: A Study Conducted in a Tertiary Care Hospital of Gujarat |
| title_sort | neonatal screening for congenital hypothyroidism a study conducted in a tertiary care hospital of gujarat |
| topic | congenital hypothyroidism neonatal screening thyroid stimulating hormone |
| url | https://www.ijmb.in/doi/IJMB/pdf/10.5005/jp-journals-10054-0229 |
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