Restricting SLC7A5-mediated Leucine uptake in T cells prevents acute GVHD and maintains GVT response

Restricting SLC7A5-mediated Leucine uptake in T cells prevents acute GVHD and maintains GVT response

Abstract The L-Leu amino acid transporter SLC7A5 has become an important target in inflammation and cancer. However, its role in acute graft-versus-host disease (aGVHD) and graft versus tumor (GVT) remains unexplored. We demonstrate that SLC7A5 deletion affected T cell activation, expansion and surv...

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Main Authors: Nieves Fernández-Gallego, Blanca Anega, Susana Luengo-Arias, Maider Bizkarguenaga, Rubén Gil-Redondo, Nieves Embade, Laura Navarrete-Arias, Marta Ramírez-Huesca, Emigdio Álvarez-Corrales, Sara G Dosil, Raquel Castillo-González, Amelia Rojas-Gomez, Inés Espeleta, Sara Martínez-Martínez, Arantzazu Alfranca, Virginia G de Yebenes, Noa Beatriz Martín-Cófreces, Julián Aragonés, Pilar Martin, Oscar Millet, Francisco Sánchez-Madrid, Danay Cibrian
Format: Article
Language:English
Published: Springer Nature 2025-05-01
Series:EMBO Molecular Medicine
Subjects:
Graft-versus-Host Disease
Graft-versus-Tumor
SLC7A5
L-Leu
T-Cell-Metabolism
Online Access:https://doi.org/10.1038/s44321-025-00250-2
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