In situ immune response in human chromoblastomycosis--a possible role for regulatory and Th17 T cells.
<h4>Background</h4>Chromoblastomycosis is a chronic fungal infection that affects skin and subcutaneous tissue. Lesions can be classified in tumorous, verrucous, cicatricial and plaque type. The cellular immune response in the severe form of the disease seems to correlate with a Th2 patt...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-09-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0003162&type=printable |
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| author | Aline Alves de Lima Silva Paulo Ricardo Criado Ricardo Spina Nunes Wellington Luiz Ferreira da Silva Luciane Kanashiro-Galo Maria Irma Seixas Duarte Mirian N Sotto Carla Pagliari |
| author_facet | Aline Alves de Lima Silva Paulo Ricardo Criado Ricardo Spina Nunes Wellington Luiz Ferreira da Silva Luciane Kanashiro-Galo Maria Irma Seixas Duarte Mirian N Sotto Carla Pagliari |
| author_sort | Aline Alves de Lima Silva |
| collection | DOAJ |
| description | <h4>Background</h4>Chromoblastomycosis is a chronic fungal infection that affects skin and subcutaneous tissue. Lesions can be classified in tumorous, verrucous, cicatricial and plaque type. The cellular immune response in the severe form of the disease seems to correlate with a Th2 pattern of cytokines. The humoral immune response also seems to play a role. We intended to explore the populations of regulatory T cells and the Th17 pattern.<h4>Methodology</h4>Twenty-three biopsies of verrucous form were obtained from patients with clinical, culture and histopathological diagnostic of chromoblastomycosis, without treatment. It was performed an immunohistochemistry method to detect Foxp3, CD25, TGF-β, IL-6, IL-17 and IL-23.<h4>Principal findings</h4>IL-17 was the only cytokine with high expression in CBM when compared to normal skin. The expression of Treg cells, TGF- β, IL-6 and IL-23 were similar to normal skin.<h4>Conclusions/significance</h4>The constitution of a local immune response with high expression of IL-17 and low expression of other cytokines could be at least in part, an attempt to help the immune system against fungal infection. On the other hand, high levels of local immune response mediated by Th17 profile could overcome the role of Treg cells. The inefficient immunomodulation as a consequence of the unbalance by Treg/Th17 cells seems to corroborate with the less effective immune response against fungi. |
| format | Article |
| id | doaj-art-80af9fc2a0ef4e4fbdf9c75fb2329d2a |
| institution | Kabale University |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2014-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-80af9fc2a0ef4e4fbdf9c75fb2329d2a2025-01-16T05:32:27ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352014-09-0189e316210.1371/journal.pntd.0003162In situ immune response in human chromoblastomycosis--a possible role for regulatory and Th17 T cells.Aline Alves de Lima SilvaPaulo Ricardo CriadoRicardo Spina NunesWellington Luiz Ferreira da SilvaLuciane Kanashiro-GaloMaria Irma Seixas DuarteMirian N SottoCarla Pagliari<h4>Background</h4>Chromoblastomycosis is a chronic fungal infection that affects skin and subcutaneous tissue. Lesions can be classified in tumorous, verrucous, cicatricial and plaque type. The cellular immune response in the severe form of the disease seems to correlate with a Th2 pattern of cytokines. The humoral immune response also seems to play a role. We intended to explore the populations of regulatory T cells and the Th17 pattern.<h4>Methodology</h4>Twenty-three biopsies of verrucous form were obtained from patients with clinical, culture and histopathological diagnostic of chromoblastomycosis, without treatment. It was performed an immunohistochemistry method to detect Foxp3, CD25, TGF-β, IL-6, IL-17 and IL-23.<h4>Principal findings</h4>IL-17 was the only cytokine with high expression in CBM when compared to normal skin. The expression of Treg cells, TGF- β, IL-6 and IL-23 were similar to normal skin.<h4>Conclusions/significance</h4>The constitution of a local immune response with high expression of IL-17 and low expression of other cytokines could be at least in part, an attempt to help the immune system against fungal infection. On the other hand, high levels of local immune response mediated by Th17 profile could overcome the role of Treg cells. The inefficient immunomodulation as a consequence of the unbalance by Treg/Th17 cells seems to corroborate with the less effective immune response against fungi.https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0003162&type=printable |
| spellingShingle | Aline Alves de Lima Silva Paulo Ricardo Criado Ricardo Spina Nunes Wellington Luiz Ferreira da Silva Luciane Kanashiro-Galo Maria Irma Seixas Duarte Mirian N Sotto Carla Pagliari In situ immune response in human chromoblastomycosis--a possible role for regulatory and Th17 T cells. PLoS Neglected Tropical Diseases |
| title | In situ immune response in human chromoblastomycosis--a possible role for regulatory and Th17 T cells. |
| title_full | In situ immune response in human chromoblastomycosis--a possible role for regulatory and Th17 T cells. |
| title_fullStr | In situ immune response in human chromoblastomycosis--a possible role for regulatory and Th17 T cells. |
| title_full_unstemmed | In situ immune response in human chromoblastomycosis--a possible role for regulatory and Th17 T cells. |
| title_short | In situ immune response in human chromoblastomycosis--a possible role for regulatory and Th17 T cells. |
| title_sort | in situ immune response in human chromoblastomycosis a possible role for regulatory and th17 t cells |
| url | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0003162&type=printable |
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