Effects of Eight Weeks of Endurance and Resistance Training on Serum Level of Apoptotic Indicators in Elderly Women
Introduction: The elderly's increased apoptosis causes physical function decline and quality of life loss, requiring non-pharmacological apoptosis regulation techniques. The present study was aimed at examining the effects of eight weeks of endurance and resistance training on apoptotic marker...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Ilam University of Medical Sciences
2025-07-01
|
| Series: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām |
| Subjects: | |
| Online Access: | http://sjimu.medilam.ac.ir/article-1-8561-en.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Introduction: The elderly's increased apoptosis causes physical function decline and quality of life loss, requiring non-pharmacological apoptosis regulation techniques. The present study was aimed at examining the effects of eight weeks of endurance and resistance training on apoptotic markers in elderly women.
Materials & Methods: A study involving 39 women over 60 years old was conducted to measure their fitness levels. The participants were divided into three groups: endurance training, resistance training, and control. The endurance training involved walking on a treadmill at 40-70% of maximum heart rate, while the resistance training involved movements with body weight and light dumbbells at 40-70% of one repetition maximum. The exercises were performed in three 20-35-minute sessions per week for eight weeks. Blood samples were collected before and after the intervention, and serum BAX and BCL2 levels were measured using ELISA. SPSS V.21, Shapiro-Wilk test, two-way mixed analysis of variance, and Bonferroni post hoc test were employed for statistical analysis (p<0.05).
Results: Both endurance and resistance training resulted in significant decreases in serum levels of the proapoptotic protein BAX and the BAX/BCL2 ratio, as well as significant increases in the antiapoptotic protein BCL2 (P < 0.05). A comparison between the two training groups showed that resistance training produced a greater decrease in BAX, while endurance training produced a greater increase in BCL2. This difference in protein response between the two training types was statistically significant (P = 0.026).
Conclusion: Regular physical activity, particularly endurance and resistance training, may be an effective non-pharmacological strategy for enhancing cellular health and modulating apoptotic processes in older adults. |
|---|---|
| ISSN: | 1563-4728 2588-3135 |