Nrf2-Independent Anti-Inflammatory Effects of Dimethyl Fumarate: Challenges and Prospects in Developing Electrophilic Nrf2 Activators for Neurodegenerative Diseases

Nrf2-Independent Anti-Inflammatory Effects of Dimethyl Fumarate: Challenges and Prospects in Developing Electrophilic Nrf2 Activators for Neurodegenerative Diseases

The NF-E2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway is a potential therapeutic target for central nervous system diseases. This review emphasizes the role of oxidative stress and neuroinflammation in neurodegenerative diseases, highlighting the therapeutic potential of Nrf2...

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Bibliographic Details
Main Authors:	Yasuhiko Izumi, Yutaka Koyama
Format:	Article
Language:	English
Published:	MDPI AG 2024-12-01
Series:	Antioxidants
Subjects:	electrophilic Nrf2 activators antioxidant effect anti-inflammatory effect dimethyl fumarate monomethyl fumarate
Online Access:	https://www.mdpi.com/2076-3921/13/12/1527
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