Traversing the epigenetic landscape: DNA methylation from retina to brain in development and disease
DNA methylation plays a crucial role in development, aging, degeneration of various tissues and dedifferentiated cells. This review explores the multifaceted impact of DNA methylation on the retina and brain during development and pathological processes. First, we investigate the role of DNA methyla...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2024.1499719/full |
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| author | Chunxiu Xu Chunxiu Xu Xuefei Fu Xuefei Fu Huan Qin Huan Qin Kai Yao Kai Yao |
| author_facet | Chunxiu Xu Chunxiu Xu Xuefei Fu Xuefei Fu Huan Qin Huan Qin Kai Yao Kai Yao |
| author_sort | Chunxiu Xu |
| collection | DOAJ |
| description | DNA methylation plays a crucial role in development, aging, degeneration of various tissues and dedifferentiated cells. This review explores the multifaceted impact of DNA methylation on the retina and brain during development and pathological processes. First, we investigate the role of DNA methylation in retinal development, and then focus on retinal diseases, detailing the changes in DNA methylation patterns in diseases such as diabetic retinopathy (DR), age-related macular degeneration (AMD), and glaucoma. Since the retina is considered an extension of the brain, its unique structure allows it to exhibit similar immune response mechanisms to the brain. We further extend our exploration from the retina to the brain, examining the role of DNA methylation in brain development and its associated diseases, such as Alzheimer’s disease (AD) and Huntington’s disease (HD) to better understand the mechanistic links between retinal and brain diseases, and explore the possibility of communication between the visual system and the central nervous system (CNS) from an epigenetic perspective. Additionally, we discuss neurodevelopmental brain diseases, including schizophrenia (SZ), autism spectrum disorder (ASD), and intellectual disability (ID), focus on how DNA methylation affects neuronal development, synaptic plasticity, and cognitive function, providing insights into the molecular mechanisms underlying neurodevelopmental disorders. |
| format | Article |
| id | doaj-art-80374ae64f6041c796a30f95c50549e7 |
| institution | Kabale University |
| issn | 1662-5102 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj-art-80374ae64f6041c796a30f95c50549e72024-11-29T04:31:37ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022024-11-011810.3389/fncel.2024.14997191499719Traversing the epigenetic landscape: DNA methylation from retina to brain in development and diseaseChunxiu Xu0Chunxiu Xu1Xuefei Fu2Xuefei Fu3Huan Qin4Huan Qin5Kai Yao6Kai Yao7Institute of Visual Neuroscience and Stem Cell Engineering, Wuhan University of Science and Technology, Wuhan, ChinaCollege of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, ChinaInstitute of Visual Neuroscience and Stem Cell Engineering, Wuhan University of Science and Technology, Wuhan, ChinaCollege of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, ChinaInstitute of Visual Neuroscience and Stem Cell Engineering, Wuhan University of Science and Technology, Wuhan, ChinaCollege of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, ChinaInstitute of Visual Neuroscience and Stem Cell Engineering, Wuhan University of Science and Technology, Wuhan, ChinaCollege of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, ChinaDNA methylation plays a crucial role in development, aging, degeneration of various tissues and dedifferentiated cells. This review explores the multifaceted impact of DNA methylation on the retina and brain during development and pathological processes. First, we investigate the role of DNA methylation in retinal development, and then focus on retinal diseases, detailing the changes in DNA methylation patterns in diseases such as diabetic retinopathy (DR), age-related macular degeneration (AMD), and glaucoma. Since the retina is considered an extension of the brain, its unique structure allows it to exhibit similar immune response mechanisms to the brain. We further extend our exploration from the retina to the brain, examining the role of DNA methylation in brain development and its associated diseases, such as Alzheimer’s disease (AD) and Huntington’s disease (HD) to better understand the mechanistic links between retinal and brain diseases, and explore the possibility of communication between the visual system and the central nervous system (CNS) from an epigenetic perspective. Additionally, we discuss neurodevelopmental brain diseases, including schizophrenia (SZ), autism spectrum disorder (ASD), and intellectual disability (ID), focus on how DNA methylation affects neuronal development, synaptic plasticity, and cognitive function, providing insights into the molecular mechanisms underlying neurodevelopmental disorders.https://www.frontiersin.org/articles/10.3389/fncel.2024.1499719/fullDNA methylation and DNA demethylationdiabetic retinopathyage-related macular degenerationglaucomaschizophreniaautism spectrum disorder |
| spellingShingle | Chunxiu Xu Chunxiu Xu Xuefei Fu Xuefei Fu Huan Qin Huan Qin Kai Yao Kai Yao Traversing the epigenetic landscape: DNA methylation from retina to brain in development and disease Frontiers in Cellular Neuroscience DNA methylation and DNA demethylation diabetic retinopathy age-related macular degeneration glaucoma schizophrenia autism spectrum disorder |
| title | Traversing the epigenetic landscape: DNA methylation from retina to brain in development and disease |
| title_full | Traversing the epigenetic landscape: DNA methylation from retina to brain in development and disease |
| title_fullStr | Traversing the epigenetic landscape: DNA methylation from retina to brain in development and disease |
| title_full_unstemmed | Traversing the epigenetic landscape: DNA methylation from retina to brain in development and disease |
| title_short | Traversing the epigenetic landscape: DNA methylation from retina to brain in development and disease |
| title_sort | traversing the epigenetic landscape dna methylation from retina to brain in development and disease |
| topic | DNA methylation and DNA demethylation diabetic retinopathy age-related macular degeneration glaucoma schizophrenia autism spectrum disorder |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2024.1499719/full |
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