Baseline shock index and baroreflex function in older adults
Elevations in shock index (SI), defined as heart rate (HR)/systolic blood pressure (BP) are less discriminative of impending shock in older adults. We hypothesized baroreflex dysfunction as a potential explanation for lower baseline SI in older adults. 52 older adults (29 women, 23 men, age ≥ 65; me...
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| Language: | English |
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Elsevier
2025-03-01
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| Series: | Aging and Health Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667032125000010 |
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| author | Kenneth M. Madden Boris Feldman Graydon S. Meneilly |
| author_facet | Kenneth M. Madden Boris Feldman Graydon S. Meneilly |
| author_sort | Kenneth M. Madden |
| collection | DOAJ |
| description | Elevations in shock index (SI), defined as heart rate (HR)/systolic blood pressure (BP) are less discriminative of impending shock in older adults. We hypothesized baroreflex dysfunction as a potential explanation for lower baseline SI in older adults. 52 older adults (29 women, 23 men, age ≥ 65; mean age 77.8 ± 0.9 years) were recruited. SI, the modified shock index (MSI, HR/mean BP), and the age corrected SI (Age * SI) as well as baroreflex function (using the sequence method) was measured at baseline. SI (Standardized β = 0.392, p = 0.005), MSI (Standardized β = 0.385, p = 0.006) and Age * SI (Standardized β = 0.431, p = 0.002) showed significant positive associations with BRSup. Age * SI also showed a significant positive association with BRS (Standardized β = 0.329, p = 0.019). Autonomic dysfunction is associated with lower SI in older adults, potentially masking circulatory instability.ClinicalTrials.gov ID NCT01914133 |
| format | Article |
| id | doaj-art-802e4c96627d4c1da013a350d857a032 |
| institution | Kabale University |
| issn | 2667-0321 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Aging and Health Research |
| spelling | doaj-art-802e4c96627d4c1da013a350d857a0322025-01-16T04:29:22ZengElsevierAging and Health Research2667-03212025-03-0151100220Baseline shock index and baroreflex function in older adultsKenneth M. Madden0Boris Feldman1Graydon S. Meneilly2Gerontology and Diabetes Research Laboratory, Division of Geriatric Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Centre for Aging SMART, University of British Columbia, Vancouver, British Columbia, Canada; UBC Centre for Healthy Aging, University of British Columbia, Vancouver, British Columbia, Canada; Corresponding author at: Allan M. McGavin Chair in Geriatric Medicine, Department of Medicine, University of British Columbia, Room 7185–Gordon and Leslie Diamond Health Care Centre, 2775 Laurel St., Vancouver, BC, V5Z 1M9, Canada.Gerontology and Diabetes Research Laboratory, Division of Geriatric Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, CanadaGerontology and Diabetes Research Laboratory, Division of Geriatric Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, CanadaElevations in shock index (SI), defined as heart rate (HR)/systolic blood pressure (BP) are less discriminative of impending shock in older adults. We hypothesized baroreflex dysfunction as a potential explanation for lower baseline SI in older adults. 52 older adults (29 women, 23 men, age ≥ 65; mean age 77.8 ± 0.9 years) were recruited. SI, the modified shock index (MSI, HR/mean BP), and the age corrected SI (Age * SI) as well as baroreflex function (using the sequence method) was measured at baseline. SI (Standardized β = 0.392, p = 0.005), MSI (Standardized β = 0.385, p = 0.006) and Age * SI (Standardized β = 0.431, p = 0.002) showed significant positive associations with BRSup. Age * SI also showed a significant positive association with BRS (Standardized β = 0.329, p = 0.019). Autonomic dysfunction is associated with lower SI in older adults, potentially masking circulatory instability.ClinicalTrials.gov ID NCT01914133http://www.sciencedirect.com/science/article/pii/S2667032125000010Shock indexBaroreflex functionOrthostasisOlder adults |
| spellingShingle | Kenneth M. Madden Boris Feldman Graydon S. Meneilly Baseline shock index and baroreflex function in older adults Aging and Health Research Shock index Baroreflex function Orthostasis Older adults |
| title | Baseline shock index and baroreflex function in older adults |
| title_full | Baseline shock index and baroreflex function in older adults |
| title_fullStr | Baseline shock index and baroreflex function in older adults |
| title_full_unstemmed | Baseline shock index and baroreflex function in older adults |
| title_short | Baseline shock index and baroreflex function in older adults |
| title_sort | baseline shock index and baroreflex function in older adults |
| topic | Shock index Baroreflex function Orthostasis Older adults |
| url | http://www.sciencedirect.com/science/article/pii/S2667032125000010 |
| work_keys_str_mv | AT kennethmmadden baselineshockindexandbaroreflexfunctioninolderadults AT borisfeldman baselineshockindexandbaroreflexfunctioninolderadults AT graydonsmeneilly baselineshockindexandbaroreflexfunctioninolderadults |