Case report: Mucormycosis due to Rhizopus microsporus: an important reminder of opportunistic infections in immunocompromised acute myeloid leukemia
Hematologic malignancies, diabetes, and the development and widespread use of novel anticancer and immunosuppressive agents have introduced a new dimension of immunosuppression, raising concerns about emerging opportunistic infections. Here, we report a case of mucormycosis in a patient with therapy...
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Frontiers Media S.A.
2025-01-01
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| Series: | Journal of Cutaneous Immunology and Allergy |
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| Online Access: | https://www.frontierspartnerships.org/articles/10.3389/jcia.2024.13995/full |
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| author | Misato Higuchi Katsutaro Nishimoto Tomoka Waseda Motoi Takenaka Motoi Takenaka Hiroyuki Murota Hiroyuki Murota |
| author_facet | Misato Higuchi Katsutaro Nishimoto Tomoka Waseda Motoi Takenaka Motoi Takenaka Hiroyuki Murota Hiroyuki Murota |
| author_sort | Misato Higuchi |
| collection | DOAJ |
| description | Hematologic malignancies, diabetes, and the development and widespread use of novel anticancer and immunosuppressive agents have introduced a new dimension of immunosuppression, raising concerns about emerging opportunistic infections. Here, we report a case of mucormycosis in a patient with therapy-related acute myeloid leukemia, encountered in our department. The patient presented with a necrotic lesion around the right eyelid. In this case, the condition and skin lesions rapidly progressed, and the patient passed away within a few days of the appearance of necrotic plaques. The causative organism was identified as Rhizopus microsporus. Mucormycosis is a severe invasive fungal infection that can rapidly worsen the prognosis of immunocompromised patients. Cutaneous mucormycosis is classified into primary and secondary forms. Based on the findings and the underlying disease, secondary cutaneous mucormycosis was suspected. Familiarity with the characteristic clinical features of mucormycosis may be the key factor in initiating timely treatment. |
| format | Article |
| id | doaj-art-8005a257aace4ee98a8359a0b1b71d31 |
| institution | Kabale University |
| issn | 2574-4593 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Journal of Cutaneous Immunology and Allergy |
| spelling | doaj-art-8005a257aace4ee98a8359a0b1b71d312025-01-03T04:11:48ZengFrontiers Media S.A.Journal of Cutaneous Immunology and Allergy2574-45932025-01-01710.3389/jcia.2024.1399513995Case report: Mucormycosis due to Rhizopus microsporus: an important reminder of opportunistic infections in immunocompromised acute myeloid leukemiaMisato Higuchi0Katsutaro Nishimoto1Tomoka Waseda2Motoi Takenaka3Motoi Takenaka4Hiroyuki Murota5Hiroyuki Murota6Department of Dermatology and Allergology, Nagasaki University Hospital, Nagasaki, JapanDepartment of Dermatology, Nagasaki Ekisaikai Hospital, Nagasaki, JapanDepartment of Dermatology and Allergology, Nagasaki University Hospital, Nagasaki, JapanDepartment of Dermatology and Allergology, Nagasaki University Hospital, Nagasaki, JapanDepartment of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanDepartment of Dermatology and Allergology, Nagasaki University Hospital, Nagasaki, JapanDepartment of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanHematologic malignancies, diabetes, and the development and widespread use of novel anticancer and immunosuppressive agents have introduced a new dimension of immunosuppression, raising concerns about emerging opportunistic infections. Here, we report a case of mucormycosis in a patient with therapy-related acute myeloid leukemia, encountered in our department. The patient presented with a necrotic lesion around the right eyelid. In this case, the condition and skin lesions rapidly progressed, and the patient passed away within a few days of the appearance of necrotic plaques. The causative organism was identified as Rhizopus microsporus. Mucormycosis is a severe invasive fungal infection that can rapidly worsen the prognosis of immunocompromised patients. Cutaneous mucormycosis is classified into primary and secondary forms. Based on the findings and the underlying disease, secondary cutaneous mucormycosis was suspected. Familiarity with the characteristic clinical features of mucormycosis may be the key factor in initiating timely treatment.https://www.frontierspartnerships.org/articles/10.3389/jcia.2024.13995/fullimmnocompromisedmucormycosisRhizopus microsporesacute myeloid leukemiainfection |
| spellingShingle | Misato Higuchi Katsutaro Nishimoto Tomoka Waseda Motoi Takenaka Motoi Takenaka Hiroyuki Murota Hiroyuki Murota Case report: Mucormycosis due to Rhizopus microsporus: an important reminder of opportunistic infections in immunocompromised acute myeloid leukemia Journal of Cutaneous Immunology and Allergy immnocompromised mucormycosis Rhizopus microspores acute myeloid leukemia infection |
| title | Case report: Mucormycosis due to Rhizopus microsporus: an important reminder of opportunistic infections in immunocompromised acute myeloid leukemia |
| title_full | Case report: Mucormycosis due to Rhizopus microsporus: an important reminder of opportunistic infections in immunocompromised acute myeloid leukemia |
| title_fullStr | Case report: Mucormycosis due to Rhizopus microsporus: an important reminder of opportunistic infections in immunocompromised acute myeloid leukemia |
| title_full_unstemmed | Case report: Mucormycosis due to Rhizopus microsporus: an important reminder of opportunistic infections in immunocompromised acute myeloid leukemia |
| title_short | Case report: Mucormycosis due to Rhizopus microsporus: an important reminder of opportunistic infections in immunocompromised acute myeloid leukemia |
| title_sort | case report mucormycosis due to rhizopus microsporus an important reminder of opportunistic infections in immunocompromised acute myeloid leukemia |
| topic | immnocompromised mucormycosis Rhizopus microspores acute myeloid leukemia infection |
| url | https://www.frontierspartnerships.org/articles/10.3389/jcia.2024.13995/full |
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