Distinct UPR and Autophagic Functions Define Cell-Specific Responses to Proteotoxic Stress in Microglial and Neuronal Cell Lines

Distinct UPR and Autophagic Functions Define Cell-Specific Responses to Proteotoxic Stress in Microglial and Neuronal Cell Lines

Autophagy is a catabolic process involved in different cellular functions. However, the molecular pathways governing its potential roles in different cell types remain poorly understood. We investigated the role of autophagy in the context of proteotoxic stress in two central nervous system cell typ...

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Bibliographic Details
Main Authors: Helena Domínguez-Martín, Elena Gavilán, Celia Parrado, Miguel A. Burguillos, Paula Daza, Diego Ruano
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Cells
Subjects:
proteotoxic stress
autophagy
proteasome
microglia
neurons
phagocytosis
Online Access:https://www.mdpi.com/2073-4409/13/24/2069
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https://www.mdpi.com/2073-4409/13/24/2069

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