Association between sperm DNA fragmentation index and recurrent pregnancy loss: results from 1485 participants undergoing fertility evaluation
ObjectiveSeveral male factors have been reported to play a role in recurrent pregnancy loss (RPL). The aim of this study is to explore the relationship between semen parameters, sperm DNA fragmentation index (DFI) and RPL.MethodA total of 1485 participants were recruited from a university hospital b...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1493186/full |
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| author | Guanying Yao Xianchao Dou Xiaozhu Chen Haolin Qi Jianling Chen Peiwei Wu Jialu Li Shuang Liang Zhongjiang Han Shun Bai Xu Hu |
| author_facet | Guanying Yao Xianchao Dou Xiaozhu Chen Haolin Qi Jianling Chen Peiwei Wu Jialu Li Shuang Liang Zhongjiang Han Shun Bai Xu Hu |
| author_sort | Guanying Yao |
| collection | DOAJ |
| description | ObjectiveSeveral male factors have been reported to play a role in recurrent pregnancy loss (RPL). The aim of this study is to explore the relationship between semen parameters, sperm DNA fragmentation index (DFI) and RPL.MethodA total of 1485 participants were recruited from a university hospital between April 2020 and August 2022. Six hundred and thirtyfour men from couples with RPL were assigned to the case group, while 851 men from couple without RPL who underwent fertile evaluation were assigned to the control group. Semen parameters including sperm DNA fragmentation, were assessed. ResultsNo statistically significant differences in semen parameters, sperm kinematics and DFI were observed between the case group and the control group. A higher proportion of men in the case group had a DFI > 30% compared to those in the control group; however, this difference was not statistically significant. Restricted cubic spline analysis revealed no significant non-linear relationships between continuous DFI and risk of RPL.ConclusionOur study indicates that there is no significant relationship between DFI and RPL risk. Further prospective studies are needed to explore the impact of DFI on fertility outcomes in couples experiencing RPL. |
| format | Article |
| id | doaj-art-7fd49c6305274b67b8048e6fbfdc274b |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-7fd49c6305274b67b8048e6fbfdc274b2025-01-07T05:23:57ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.14931861493186Association between sperm DNA fragmentation index and recurrent pregnancy loss: results from 1485 participants undergoing fertility evaluationGuanying Yao0Xianchao Dou1Xiaozhu Chen2Haolin Qi3Jianling Chen4Peiwei Wu5Jialu Li6Shuang Liang7Zhongjiang Han8Shun Bai9Xu Hu10Department of Reproductive Medicine, Nanyang Central Hospital, Nanyang, ChinaSchool of Medical Imaging, Bengbu Medical University, Bengbu, ChinaSchool of Nursing, Anhui University of Chinese Medicine, Hefei, ChinaSydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, AustraliaDepartment of Reproductive Medicine, Nanyang Central Hospital, Nanyang, ChinaDepartment of Reproductive Medicine, Nanyang Central Hospital, Nanyang, ChinaDepartment of Reproductive Medicine, Nanyang Central Hospital, Nanyang, ChinaDepartment of Reproductive Medicine, Nanyang Central Hospital, Nanyang, ChinaDepartment of Reproductive Medicine, Nanyang Central Hospital, Nanyang, ChinaCenter for Reproduction and Genetics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaDepartment of Reproductive Medicine, Nanyang Central Hospital, Nanyang, ChinaObjectiveSeveral male factors have been reported to play a role in recurrent pregnancy loss (RPL). The aim of this study is to explore the relationship between semen parameters, sperm DNA fragmentation index (DFI) and RPL.MethodA total of 1485 participants were recruited from a university hospital between April 2020 and August 2022. Six hundred and thirtyfour men from couples with RPL were assigned to the case group, while 851 men from couple without RPL who underwent fertile evaluation were assigned to the control group. Semen parameters including sperm DNA fragmentation, were assessed. ResultsNo statistically significant differences in semen parameters, sperm kinematics and DFI were observed between the case group and the control group. A higher proportion of men in the case group had a DFI > 30% compared to those in the control group; however, this difference was not statistically significant. Restricted cubic spline analysis revealed no significant non-linear relationships between continuous DFI and risk of RPL.ConclusionOur study indicates that there is no significant relationship between DFI and RPL risk. Further prospective studies are needed to explore the impact of DFI on fertility outcomes in couples experiencing RPL.https://www.frontiersin.org/articles/10.3389/fendo.2024.1493186/fullDNA fragmentation indexrecurrent pregnancy losssemen qualityDFIRPL |
| spellingShingle | Guanying Yao Xianchao Dou Xiaozhu Chen Haolin Qi Jianling Chen Peiwei Wu Jialu Li Shuang Liang Zhongjiang Han Shun Bai Xu Hu Association between sperm DNA fragmentation index and recurrent pregnancy loss: results from 1485 participants undergoing fertility evaluation Frontiers in Endocrinology DNA fragmentation index recurrent pregnancy loss semen quality DFI RPL |
| title | Association between sperm DNA fragmentation index and recurrent pregnancy loss: results from 1485 participants undergoing fertility evaluation |
| title_full | Association between sperm DNA fragmentation index and recurrent pregnancy loss: results from 1485 participants undergoing fertility evaluation |
| title_fullStr | Association between sperm DNA fragmentation index and recurrent pregnancy loss: results from 1485 participants undergoing fertility evaluation |
| title_full_unstemmed | Association between sperm DNA fragmentation index and recurrent pregnancy loss: results from 1485 participants undergoing fertility evaluation |
| title_short | Association between sperm DNA fragmentation index and recurrent pregnancy loss: results from 1485 participants undergoing fertility evaluation |
| title_sort | association between sperm dna fragmentation index and recurrent pregnancy loss results from 1485 participants undergoing fertility evaluation |
| topic | DNA fragmentation index recurrent pregnancy loss semen quality DFI RPL |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1493186/full |
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