The Intricate Mechanisms of Functional Foods Oyster Mushroom and Fenugreek on Type 2 Diabetic Animal Model
Mushrooms and fenugreek are widely used to reduce hyperglycemia, and fenugreek is also used as a culinary ingredient to enhance flavor and aroma. This study is aimed at investigating the underlying mechanisms of the hypoglycemic effects of mushrooms and fenugreek in a Type 2 diabetic rat model. Aden...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/jdr/6209785 |
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| author | Arafat Hassan Razon Md. Alauddin Nisat Farzana Sanaullah Mazumdar Md. Ruhul Amin Md. Mahedi Hassan Tusher Md. Asrafuzzaman Nahid Hasan Mahfuzur Rahman Muhammad Saiedullah Begum Rokeya Md. Omar Faruque |
| author_facet | Arafat Hassan Razon Md. Alauddin Nisat Farzana Sanaullah Mazumdar Md. Ruhul Amin Md. Mahedi Hassan Tusher Md. Asrafuzzaman Nahid Hasan Mahfuzur Rahman Muhammad Saiedullah Begum Rokeya Md. Omar Faruque |
| author_sort | Arafat Hassan Razon |
| collection | DOAJ |
| description | Mushrooms and fenugreek are widely used to reduce hyperglycemia, and fenugreek is also used as a culinary ingredient to enhance flavor and aroma. This study is aimed at investigating the underlying mechanisms of the hypoglycemic effects of mushrooms and fenugreek in a Type 2 diabetic rat model. Adenosine monophosphate (AMP)–activated protein kinase (AMPK) functions to reduce hyperglycemia through insulin-independent pathways and protects beta-cells. Diabetic model rats were administered standard diets supplemented with 5% oyster mushroom powder (mushroom-treated (MT) group) and 5% fenugreek seed powder (fenugreek-treated (FT) group) for 8 weeks. The results showed improvements in both glycemic and lipid profiles, with both oyster mushroom and fenugreek enhancing the phosphorylation of AMPK in muscle tissue. However, no effect on insulin secretion was observed. These findings suggest that both substances reduce hyperglycemia through an insulin-independent pathway. In silico analysis of both mushroom and fenugreek seed extracts revealed bioactive compounds having a strong binding affinity to α-glucosidase, which suggests mushroom and fenugreek supplements might control postprandial blood glucose levels. |
| format | Article |
| id | doaj-art-7fbbc091be4d4c088375f9d9cd00c83c |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-7fbbc091be4d4c088375f9d9cd00c83c2024-12-17T00:00:04ZengWileyJournal of Diabetes Research2314-67532024-01-01202410.1155/jdr/6209785The Intricate Mechanisms of Functional Foods Oyster Mushroom and Fenugreek on Type 2 Diabetic Animal ModelArafat Hassan Razon0Md. Alauddin1Nisat Farzana2Sanaullah Mazumdar3Md. Ruhul Amin4Md. Mahedi Hassan Tusher5Md. Asrafuzzaman6Nahid Hasan7Mahfuzur Rahman8Muhammad Saiedullah9Begum Rokeya10Md. Omar Faruque11School of Science and TechnologyDepartment of Nutrition and Food TechnologyDepartment of Nutrition and Food TechnologyDepartment of Nutrition and Food TechnologyDepartment of Nutrition and Food TechnologyDepartment of PharmacologyDepartment of PharmacologyDepartment of Biochemistry and Molecular BiologyDepartment of Biochemistry and Molecular BiologyDepartment of Biochemistry and Molecular BiologyDepartment of PharmacologyDepartment of Nutrition and Food TechnologyMushrooms and fenugreek are widely used to reduce hyperglycemia, and fenugreek is also used as a culinary ingredient to enhance flavor and aroma. This study is aimed at investigating the underlying mechanisms of the hypoglycemic effects of mushrooms and fenugreek in a Type 2 diabetic rat model. Adenosine monophosphate (AMP)–activated protein kinase (AMPK) functions to reduce hyperglycemia through insulin-independent pathways and protects beta-cells. Diabetic model rats were administered standard diets supplemented with 5% oyster mushroom powder (mushroom-treated (MT) group) and 5% fenugreek seed powder (fenugreek-treated (FT) group) for 8 weeks. The results showed improvements in both glycemic and lipid profiles, with both oyster mushroom and fenugreek enhancing the phosphorylation of AMPK in muscle tissue. However, no effect on insulin secretion was observed. These findings suggest that both substances reduce hyperglycemia through an insulin-independent pathway. In silico analysis of both mushroom and fenugreek seed extracts revealed bioactive compounds having a strong binding affinity to α-glucosidase, which suggests mushroom and fenugreek supplements might control postprandial blood glucose levels.http://dx.doi.org/10.1155/jdr/6209785 |
| spellingShingle | Arafat Hassan Razon Md. Alauddin Nisat Farzana Sanaullah Mazumdar Md. Ruhul Amin Md. Mahedi Hassan Tusher Md. Asrafuzzaman Nahid Hasan Mahfuzur Rahman Muhammad Saiedullah Begum Rokeya Md. Omar Faruque The Intricate Mechanisms of Functional Foods Oyster Mushroom and Fenugreek on Type 2 Diabetic Animal Model Journal of Diabetes Research |
| title | The Intricate Mechanisms of Functional Foods Oyster Mushroom and Fenugreek on Type 2 Diabetic Animal Model |
| title_full | The Intricate Mechanisms of Functional Foods Oyster Mushroom and Fenugreek on Type 2 Diabetic Animal Model |
| title_fullStr | The Intricate Mechanisms of Functional Foods Oyster Mushroom and Fenugreek on Type 2 Diabetic Animal Model |
| title_full_unstemmed | The Intricate Mechanisms of Functional Foods Oyster Mushroom and Fenugreek on Type 2 Diabetic Animal Model |
| title_short | The Intricate Mechanisms of Functional Foods Oyster Mushroom and Fenugreek on Type 2 Diabetic Animal Model |
| title_sort | intricate mechanisms of functional foods oyster mushroom and fenugreek on type 2 diabetic animal model |
| url | http://dx.doi.org/10.1155/jdr/6209785 |
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