Polymorphism rs564398 of the ANRIL Gene as a Coronary-Artery-Disease-Associated SNP in Diabetic Patients of the Kazakh Population
Background/Objectives. A cardiovascular complication of type 2 diabetes mellitus like coronary artery disease is influenced by a complex interplay between environmental, phenotypic, and genetic factors. The genetic mechanisms in the development of this pathology are not established. This study aims...
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2024-10-01
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| author | Alisher Aitkaliyev Nazira Bekenova Tamara Vochshenkova Balzhan Kassiyeva Valeriy Benberin |
| author_facet | Alisher Aitkaliyev Nazira Bekenova Tamara Vochshenkova Balzhan Kassiyeva Valeriy Benberin |
| author_sort | Alisher Aitkaliyev |
| collection | DOAJ |
| description | Background/Objectives. A cardiovascular complication of type 2 diabetes mellitus like coronary artery disease is influenced by a complex interplay between environmental, phenotypic, and genetic factors. The genetic mechanisms in the development of this pathology are not established. This study aims to evaluate the association of polymorphisms rs1011970, rs62560775, and rs564398 from the 9p21.3 locus with coronary artery disease in diabetic patients of the Kazakh population. Methods. A total of 343 people participated in the case-control study: the control group consisted of 109 people with type 2 diabetes and coronary artery disease, while the control group included 234 people. Genotyping was performed using real-time PCR. Statistical analysis was carried out using Chi-square methods and calculating odds ratios (OR) with 95% confidence intervals (CI). Results. According to the results, only the rs564398 polymorphism of the ANRIL gene was associated with coronary artery disease (<i>p</i> = 0.04). The CC genotype increased the risk of developing coronary artery disease by more than 1.5 times (1.62 (1.02–2.56)), whereas the TT genotype reduced the risk of coronary artery disease (0.39 (0.17–0.91)). The remaining polymorphisms, rs1011970 and rs62560775, were not associated with coronary artery disease. Conclusions. Thus, this research further elicits the association of the ANRIL gene with cardiometabolic disease. |
| format | Article |
| id | doaj-art-7f90af0829424a2e9d1b9ee6cdae4a0c |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj-art-7f90af0829424a2e9d1b9ee6cdae4a0c2024-11-08T14:34:51ZengMDPI AGDiagnostics2075-44182024-10-011421241210.3390/diagnostics14212412Polymorphism rs564398 of the ANRIL Gene as a Coronary-Artery-Disease-Associated SNP in Diabetic Patients of the Kazakh PopulationAlisher Aitkaliyev0Nazira Bekenova1Tamara Vochshenkova2Balzhan Kassiyeva3Valeriy Benberin4Department of Science, Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan, Mangilik El 80, Astana 010000, KazakhstanDepartment of Science, Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan, Mangilik El 80, Astana 010000, KazakhstanDepartment of Science, Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan, Mangilik El 80, Astana 010000, KazakhstanDepartment of Science, Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan, Mangilik El 80, Astana 010000, KazakhstanDepartment of Science, Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan, Mangilik El 80, Astana 010000, KazakhstanBackground/Objectives. A cardiovascular complication of type 2 diabetes mellitus like coronary artery disease is influenced by a complex interplay between environmental, phenotypic, and genetic factors. The genetic mechanisms in the development of this pathology are not established. This study aims to evaluate the association of polymorphisms rs1011970, rs62560775, and rs564398 from the 9p21.3 locus with coronary artery disease in diabetic patients of the Kazakh population. Methods. A total of 343 people participated in the case-control study: the control group consisted of 109 people with type 2 diabetes and coronary artery disease, while the control group included 234 people. Genotyping was performed using real-time PCR. Statistical analysis was carried out using Chi-square methods and calculating odds ratios (OR) with 95% confidence intervals (CI). Results. According to the results, only the rs564398 polymorphism of the ANRIL gene was associated with coronary artery disease (<i>p</i> = 0.04). The CC genotype increased the risk of developing coronary artery disease by more than 1.5 times (1.62 (1.02–2.56)), whereas the TT genotype reduced the risk of coronary artery disease (0.39 (0.17–0.91)). The remaining polymorphisms, rs1011970 and rs62560775, were not associated with coronary artery disease. Conclusions. Thus, this research further elicits the association of the ANRIL gene with cardiometabolic disease.https://www.mdpi.com/2075-4418/14/21/2412ANRIL genecoronary artery diseasepolymorphism rs564398 |
| spellingShingle | Alisher Aitkaliyev Nazira Bekenova Tamara Vochshenkova Balzhan Kassiyeva Valeriy Benberin Polymorphism rs564398 of the ANRIL Gene as a Coronary-Artery-Disease-Associated SNP in Diabetic Patients of the Kazakh Population Diagnostics ANRIL gene coronary artery disease polymorphism rs564398 |
| title | Polymorphism rs564398 of the ANRIL Gene as a Coronary-Artery-Disease-Associated SNP in Diabetic Patients of the Kazakh Population |
| title_full | Polymorphism rs564398 of the ANRIL Gene as a Coronary-Artery-Disease-Associated SNP in Diabetic Patients of the Kazakh Population |
| title_fullStr | Polymorphism rs564398 of the ANRIL Gene as a Coronary-Artery-Disease-Associated SNP in Diabetic Patients of the Kazakh Population |
| title_full_unstemmed | Polymorphism rs564398 of the ANRIL Gene as a Coronary-Artery-Disease-Associated SNP in Diabetic Patients of the Kazakh Population |
| title_short | Polymorphism rs564398 of the ANRIL Gene as a Coronary-Artery-Disease-Associated SNP in Diabetic Patients of the Kazakh Population |
| title_sort | polymorphism rs564398 of the anril gene as a coronary artery disease associated snp in diabetic patients of the kazakh population |
| topic | ANRIL gene coronary artery disease polymorphism rs564398 |
| url | https://www.mdpi.com/2075-4418/14/21/2412 |
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