Longitudinal analyses of infants’ microbiome and metabolome reveal microbes and metabolites with seemingly coordinated dynamics
Abstract Population studies have shown that the infant’s microbiome and metabolome undergo significant changes in early childhood. However, no previous study has investigated how diverse these changes are across subjects and whether the subject-specific dynamics of some microbes correlate with the o...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-07015-6 |
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| author | Hao Wu Douglas V. Guzior Christian Martin Kerri A. Neugebauer Madison M. Rzepka Julie C. Lumeng Robert A. Quinn Gustavo de los Campos |
| author_facet | Hao Wu Douglas V. Guzior Christian Martin Kerri A. Neugebauer Madison M. Rzepka Julie C. Lumeng Robert A. Quinn Gustavo de los Campos |
| author_sort | Hao Wu |
| collection | DOAJ |
| description | Abstract Population studies have shown that the infant’s microbiome and metabolome undergo significant changes in early childhood. However, no previous study has investigated how diverse these changes are across subjects and whether the subject-specific dynamics of some microbes correlate with the over-time dynamics of specific metabolites. Using mixed-effects models, and data from the ABC study, we investigated the early childhood dynamics of fecal microbiome and metabolome and identified 83 amplicon sequence variants (ASVs) and 753 metabolites with seemingly coordinated trajectories. Enrichment analysis of these microbes and molecules revealed eight ASV families and 23 metabolite groups involving 1032 ASV-metabolite pairs with their presence-absence changing in a coordinated fashion. Members of the Lachnospiraceae (464/1032) and metabolites related to cholestane steroids (309/1032) dominated proportional shifts within the fecal microbiome and metabolome as infants aged. |
| format | Article |
| id | doaj-art-7f523212ec1b467893f9b99f8753d702 |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-7f523212ec1b467893f9b99f8753d7022024-11-17T12:42:35ZengNature PortfolioCommunications Biology2399-36422024-11-017111010.1038/s42003-024-07015-6Longitudinal analyses of infants’ microbiome and metabolome reveal microbes and metabolites with seemingly coordinated dynamicsHao Wu0Douglas V. Guzior1Christian Martin2Kerri A. Neugebauer3Madison M. Rzepka4Julie C. Lumeng5Robert A. Quinn6Gustavo de los Campos7Department of Epidemiology and Biostatistics, Michigan State UniversityDepartment of Microbiology, Genetics, and Immunology, Michigan State UniversityDepartment of Biochemistry and Molecular Biology, Michigan State UniversityDepartment of Plant Soil and Microbiology, Michigan State UniversityDepartment of Biochemistry and Molecular Biology, Michigan State UniversityDepartment of Pediatrics, University of Michigan Medical SchoolDepartment of Biochemistry and Molecular Biology, Michigan State UniversityDepartment of Epidemiology and Biostatistics, Michigan State UniversityAbstract Population studies have shown that the infant’s microbiome and metabolome undergo significant changes in early childhood. However, no previous study has investigated how diverse these changes are across subjects and whether the subject-specific dynamics of some microbes correlate with the over-time dynamics of specific metabolites. Using mixed-effects models, and data from the ABC study, we investigated the early childhood dynamics of fecal microbiome and metabolome and identified 83 amplicon sequence variants (ASVs) and 753 metabolites with seemingly coordinated trajectories. Enrichment analysis of these microbes and molecules revealed eight ASV families and 23 metabolite groups involving 1032 ASV-metabolite pairs with their presence-absence changing in a coordinated fashion. Members of the Lachnospiraceae (464/1032) and metabolites related to cholestane steroids (309/1032) dominated proportional shifts within the fecal microbiome and metabolome as infants aged.https://doi.org/10.1038/s42003-024-07015-6 |
| spellingShingle | Hao Wu Douglas V. Guzior Christian Martin Kerri A. Neugebauer Madison M. Rzepka Julie C. Lumeng Robert A. Quinn Gustavo de los Campos Longitudinal analyses of infants’ microbiome and metabolome reveal microbes and metabolites with seemingly coordinated dynamics Communications Biology |
| title | Longitudinal analyses of infants’ microbiome and metabolome reveal microbes and metabolites with seemingly coordinated dynamics |
| title_full | Longitudinal analyses of infants’ microbiome and metabolome reveal microbes and metabolites with seemingly coordinated dynamics |
| title_fullStr | Longitudinal analyses of infants’ microbiome and metabolome reveal microbes and metabolites with seemingly coordinated dynamics |
| title_full_unstemmed | Longitudinal analyses of infants’ microbiome and metabolome reveal microbes and metabolites with seemingly coordinated dynamics |
| title_short | Longitudinal analyses of infants’ microbiome and metabolome reveal microbes and metabolites with seemingly coordinated dynamics |
| title_sort | longitudinal analyses of infants microbiome and metabolome reveal microbes and metabolites with seemingly coordinated dynamics |
| url | https://doi.org/10.1038/s42003-024-07015-6 |
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