Exposure to low-dose ionising radiation from cardiac catheterisation and risk of cancer: the COCCINELLE study cohort profile
Purpose The COCCINELLE study is a nationwide retrospective French cohort set up to evaluate the risk of cancer in patients who undergone cardiac catheterisation (CC) procedures for diagnosis or treatment of congenital heart disease during childhood.Participants Children who undergone CC procedures f...
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BMJ Publishing Group
2021-08-01
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| Online Access: | https://bmjopen.bmj.com/content/11/8/e048576.full |
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| author | Damien Bonnet Claire Dauphin Stéphanie Douchin Sarah Cohen Estelle Rage Clément Karsenty Jean-Benoît Thambo FRANCOIS GODART Klervi Leuraud Marie-Odile Bernier Caroline Ovaert Jean-François Piéchaud Sébastien Hascoet Kossi Dovene Abalo Sophie Malekzadeh-Milani Serge Dreuil Tiphaine Feuillet Sylvie Di Filippo Patrice Guérin Pauline Helms Bruno Lefort Pierre Mauran |
| author_facet | Damien Bonnet Claire Dauphin Stéphanie Douchin Sarah Cohen Estelle Rage Clément Karsenty Jean-Benoît Thambo FRANCOIS GODART Klervi Leuraud Marie-Odile Bernier Caroline Ovaert Jean-François Piéchaud Sébastien Hascoet Kossi Dovene Abalo Sophie Malekzadeh-Milani Serge Dreuil Tiphaine Feuillet Sylvie Di Filippo Patrice Guérin Pauline Helms Bruno Lefort Pierre Mauran |
| author_sort | Damien Bonnet |
| collection | DOAJ |
| description | Purpose The COCCINELLE study is a nationwide retrospective French cohort set up to evaluate the risk of cancer in patients who undergone cardiac catheterisation (CC) procedures for diagnosis or treatment of congenital heart disease during childhood.Participants Children who undergone CC procedures from 1 January 2000 to 31 December 2013, before the age of 16 in one of the 15 paediatric cardiology departments which perform paediatric CC in mainland France were included. The follow-up started at the date of the first recorded CC procedure until the exit date, that is, the date of death, the date of first cancer diagnosis, the date of the 18th birthday or the 31 December 2015, whichever occurred first. The cohort was linked to the National Childhood Cancer Registry to identify patients diagnosed with cancer and with the French National Directory for the Identification of Natural Persons to retrieve the patients’ vital status.Findings to date A total of 17 104 children were included in the cohort and followed for 110 335 person-years, with 22 227 CC procedures collected. Among the patients, 81.6% received only one procedure. Fifty-nine cancer cases were observed in the cohort. Standardised incidence ratios (SIRs) were increased for all-cancer (SIR=3.8, 95% CI: 2.9 to 4.9), leukaemia (SIR=3.3, 95% CI: 2.0 to 5.4), lymphoma (SIR=14.9, 95% CI: 9.9 to 22.5) and solid cancers excluding central nervous system (CNS) tumours (SIR=3.3, 95% CI: 2.0 to 5.5) compared with the general population.Future plans Dose reconstruction is currently underway to estimate individual cumulative doses absorbed to relevant organs, including red bone marrow and brain for respectively haematologic disorders and CNS tumours risk estimation. A dose–response analysis will be conducted with consideration to confounding factors such as age at exposure, gender, predisposing factors to cancer and other sources of medical diagnostic low-dose ionising radiation. |
| format | Article |
| id | doaj-art-7f2ea799c6ab4c7e8e51b3526c9c425e |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-08-01 |
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| spelling | doaj-art-7f2ea799c6ab4c7e8e51b3526c9c425e2024-12-08T00:45:08ZengBMJ Publishing GroupBMJ Open2044-60552021-08-0111810.1136/bmjopen-2020-048576Exposure to low-dose ionising radiation from cardiac catheterisation and risk of cancer: the COCCINELLE study cohort profileDamien Bonnet0Claire Dauphin1Stéphanie Douchin2Sarah Cohen3Estelle Rage4Clément Karsenty5Jean-Benoît Thambo6FRANCOIS GODART7Klervi Leuraud8Marie-Odile Bernier9Caroline Ovaert10Jean-François Piéchaud11Sébastien Hascoet12Kossi Dovene Abalo13Sophie Malekzadeh-Milani14Serge Dreuil15Tiphaine Feuillet16Sylvie Di Filippo17Patrice Guérin18Pauline Helms19Bruno Lefort20Pierre Mauran213 Pediatric Cardiology Unit `centre de référence des malformations cardiaques congénitales complexes—M3C`, Necker-Enfants Malades Hospitals, Paris, Île-de-France, FranceCardiology and Vascular Department, Hopital Gabriel Montpied, Clermont-Ferrand, FranceCardiopédiatrie, Hôpital couple enfant, CHU Grenoble Alpes, Grenoble cedex 9, France, Grenoble, FranceCRISPR Therapeutics, Cambridge, MA, USA8Institute for Radiological Protection and Nuclear Safety (IRSN), PSE-SANTE, SESANE, Fontenay-aux-Roses, FrancePediatric and Congenital Cardiology, Children`s Hospital and INSERM U1048, I2MC, Institut des Maladies Métaboliques et Cardiovasculaires, Université de Toulouse, Toulouse, FranceDepartment of Pediatric and Adult Congenital Cardiology, Bordeaux University Hospital (CHU), Bordeaux, FranceService de Cardiologie Infantile et Congénitale, Institut Cœur Poumon, Lille Cedex, Lille, FrancePSE-SANTE/SESANE/Laboratory of Epidemiology, Institute for Radiological Protection and Nuclear Safety (IRSN), Fontenay-aux-Roses, Île-de-France, FrancePSE-SANTE/SESANE/LEPID, Institut de Radioprotection et de Sûreté Nucléaire, Fontenay-aux-Roses, Île-de-France, FranceCardiologie pédiatrique et congénitale, Timone enfants, AP-HM et INSERM 1251, Aix-Marseille Université, Marseille, FranceInstitut Cardiovasculaire Paris Sud, Institut Hospitalier Jacques-Cartier, Massy, France2 Congenital Heart Diseases Department, INSERM UMR-S 999, Université Paris-Saclay, Marie-Lannelongue Surgical Centre, Le Plessis-Robinson, FrancePSE-SANTE/SESANE/Laboratory of Epidemiology, Institute for Radiological Protection and Nuclear Safety (IRSN), Fontenay-aux-Roses, Île-de-France, FranceDepartment of Congenital and Pediatric Cardiology, Necker-Sick Children University Hospital, M3C-Necker, Université de Paris, Paris, FrancePSE-SANTE/SER/UEM, Institute for Radiological Protection and Nuclear Safety (IRSN), Fontenay-aux-Roses, Île-de-France, FranceAMAREXIA, Paris, FrancePaediatric and Congential Cardiology Department, Hôpital Cardiologique Louis Pradel, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Lyon, FranceinvestigatorUnit of Cardiopediatrics, University Hospital of Strasbourg, Strasbourg, FranceInstitut des Cardiopathies Congénitales, CHRU Tours, Tours, FranceUnité de cardiologie pédiatrique et congénitale, American Memorial Hospital, CHU de Reims, 47 rue Cognacq-Jay, Reims Cedex, Reims, FrancePurpose The COCCINELLE study is a nationwide retrospective French cohort set up to evaluate the risk of cancer in patients who undergone cardiac catheterisation (CC) procedures for diagnosis or treatment of congenital heart disease during childhood.Participants Children who undergone CC procedures from 1 January 2000 to 31 December 2013, before the age of 16 in one of the 15 paediatric cardiology departments which perform paediatric CC in mainland France were included. The follow-up started at the date of the first recorded CC procedure until the exit date, that is, the date of death, the date of first cancer diagnosis, the date of the 18th birthday or the 31 December 2015, whichever occurred first. The cohort was linked to the National Childhood Cancer Registry to identify patients diagnosed with cancer and with the French National Directory for the Identification of Natural Persons to retrieve the patients’ vital status.Findings to date A total of 17 104 children were included in the cohort and followed for 110 335 person-years, with 22 227 CC procedures collected. Among the patients, 81.6% received only one procedure. Fifty-nine cancer cases were observed in the cohort. Standardised incidence ratios (SIRs) were increased for all-cancer (SIR=3.8, 95% CI: 2.9 to 4.9), leukaemia (SIR=3.3, 95% CI: 2.0 to 5.4), lymphoma (SIR=14.9, 95% CI: 9.9 to 22.5) and solid cancers excluding central nervous system (CNS) tumours (SIR=3.3, 95% CI: 2.0 to 5.5) compared with the general population.Future plans Dose reconstruction is currently underway to estimate individual cumulative doses absorbed to relevant organs, including red bone marrow and brain for respectively haematologic disorders and CNS tumours risk estimation. A dose–response analysis will be conducted with consideration to confounding factors such as age at exposure, gender, predisposing factors to cancer and other sources of medical diagnostic low-dose ionising radiation.https://bmjopen.bmj.com/content/11/8/e048576.full |
| spellingShingle | Damien Bonnet Claire Dauphin Stéphanie Douchin Sarah Cohen Estelle Rage Clément Karsenty Jean-Benoît Thambo FRANCOIS GODART Klervi Leuraud Marie-Odile Bernier Caroline Ovaert Jean-François Piéchaud Sébastien Hascoet Kossi Dovene Abalo Sophie Malekzadeh-Milani Serge Dreuil Tiphaine Feuillet Sylvie Di Filippo Patrice Guérin Pauline Helms Bruno Lefort Pierre Mauran Exposure to low-dose ionising radiation from cardiac catheterisation and risk of cancer: the COCCINELLE study cohort profile BMJ Open |
| title | Exposure to low-dose ionising radiation from cardiac catheterisation and risk of cancer: the COCCINELLE study cohort profile |
| title_full | Exposure to low-dose ionising radiation from cardiac catheterisation and risk of cancer: the COCCINELLE study cohort profile |
| title_fullStr | Exposure to low-dose ionising radiation from cardiac catheterisation and risk of cancer: the COCCINELLE study cohort profile |
| title_full_unstemmed | Exposure to low-dose ionising radiation from cardiac catheterisation and risk of cancer: the COCCINELLE study cohort profile |
| title_short | Exposure to low-dose ionising radiation from cardiac catheterisation and risk of cancer: the COCCINELLE study cohort profile |
| title_sort | exposure to low dose ionising radiation from cardiac catheterisation and risk of cancer the coccinelle study cohort profile |
| url | https://bmjopen.bmj.com/content/11/8/e048576.full |
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