Atypical Presentation of Systemic Arthritis in a Toddler with Down Syndrome
Systemic juvenile idiopathic arthritis (sJIA) is a chronic, inflammatory disease of childhood, which is characterized by the combination of arthritis, serositis, daily, high-spiking fevers, and evanescent macular rash and can present with the life-threatening complication of macrophage activation sy...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2021/6567770 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841524688158720000 |
|---|---|
| author | Emily Worley Weijie Li Jordan T. Jones |
| author_facet | Emily Worley Weijie Li Jordan T. Jones |
| author_sort | Emily Worley |
| collection | DOAJ |
| description | Systemic juvenile idiopathic arthritis (sJIA) is a chronic, inflammatory disease of childhood, which is characterized by the combination of arthritis, serositis, daily, high-spiking fevers, and evanescent macular rash and can present with the life-threatening complication of macrophage activation syndrome (MAS). Children with Down syndrome (DS) have complex medical challenges related to abnormalities in their immune system, which can cause a broad spectrum of disease manifestations, which can occur atypically. Children with DS are at increased risk for arthritis and interstitial lung disease (ILD) associated with sJIA that has high mortality. This case report outlines an atypical presentation of sJIA in a 21-month-old male with DS in which fever was not part of the initial presentation of sJIA and then later developed MAS and ILD. Due to broad spectrum of disease and atypical presentation in children with DS, this case report was created to increase awareness of atypical presentations of rheumatic disease in children with DS. |
| format | Article |
| id | doaj-art-7ef7c0a91e3947c991ab1b453319c22e |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-7ef7c0a91e3947c991ab1b453319c22e2025-02-03T05:47:38ZengWileyCase Reports in Pediatrics2090-68032090-68112021-01-01202110.1155/2021/65677706567770Atypical Presentation of Systemic Arthritis in a Toddler with Down SyndromeEmily Worley0Weijie Li1Jordan T. Jones2University of Kansas School of Medicine, Kansas City, KS, USAChildren’s Mercy Kansas City, Kansas City, MO, USAUniversity of Kansas School of Medicine, Kansas City, KS, USASystemic juvenile idiopathic arthritis (sJIA) is a chronic, inflammatory disease of childhood, which is characterized by the combination of arthritis, serositis, daily, high-spiking fevers, and evanescent macular rash and can present with the life-threatening complication of macrophage activation syndrome (MAS). Children with Down syndrome (DS) have complex medical challenges related to abnormalities in their immune system, which can cause a broad spectrum of disease manifestations, which can occur atypically. Children with DS are at increased risk for arthritis and interstitial lung disease (ILD) associated with sJIA that has high mortality. This case report outlines an atypical presentation of sJIA in a 21-month-old male with DS in which fever was not part of the initial presentation of sJIA and then later developed MAS and ILD. Due to broad spectrum of disease and atypical presentation in children with DS, this case report was created to increase awareness of atypical presentations of rheumatic disease in children with DS.http://dx.doi.org/10.1155/2021/6567770 |
| spellingShingle | Emily Worley Weijie Li Jordan T. Jones Atypical Presentation of Systemic Arthritis in a Toddler with Down Syndrome Case Reports in Pediatrics |
| title | Atypical Presentation of Systemic Arthritis in a Toddler with Down Syndrome |
| title_full | Atypical Presentation of Systemic Arthritis in a Toddler with Down Syndrome |
| title_fullStr | Atypical Presentation of Systemic Arthritis in a Toddler with Down Syndrome |
| title_full_unstemmed | Atypical Presentation of Systemic Arthritis in a Toddler with Down Syndrome |
| title_short | Atypical Presentation of Systemic Arthritis in a Toddler with Down Syndrome |
| title_sort | atypical presentation of systemic arthritis in a toddler with down syndrome |
| url | http://dx.doi.org/10.1155/2021/6567770 |
| work_keys_str_mv | AT emilyworley atypicalpresentationofsystemicarthritisinatoddlerwithdownsyndrome AT weijieli atypicalpresentationofsystemicarthritisinatoddlerwithdownsyndrome AT jordantjones atypicalpresentationofsystemicarthritisinatoddlerwithdownsyndrome |