Functional interplay between condensin I and topoisomerase Iiα in single-molecule DNA compaction

Functional interplay between condensin I and topoisomerase Iiα in single-molecule DNA compaction

Abstract Condensin I and topoisomerase IIα (topo IIα) are chromosomal ATPases essential for mitotic chromosome assembly. Mechanistically how the two ATPases cooperate to assemble mitotic chromosomes remains unknown. Here we investigate the interplay between condensin I and topo IIα at single-molecul...

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Main Authors: Yuko Tsubota, Keishi Shintomi, Kazuhisa Kinoshita, Yuki Masahara-Negishi, Yuuki Aizawa, Masami Shima, Tatsuya Hirano, Tomoko Nishiyama
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62600-5
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https://doi.org/10.1038/s41467-025-62600-5

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