Clinical usefulness of patient-reported-outcome-measurement information system in Pediatric Crohn’s Disease: a cross-sectional study
Abstract Objectives This study evaluated the clinical utility of the Patient-Reported Outcomes Measurement Information System (PROMIS®) by comparing it with objective clinical data and validated health-related quality of life (HRQOL) measures in pediatric Crohn’s disease (CD) patients. Study design...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Health and Quality of Life Outcomes |
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| Online Access: | https://doi.org/10.1186/s12955-024-02330-2 |
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| author | Sara Azevedo Maria Miguel Oliveira Paulo Nogueira Ana Isabel Lopes |
| author_facet | Sara Azevedo Maria Miguel Oliveira Paulo Nogueira Ana Isabel Lopes |
| author_sort | Sara Azevedo |
| collection | DOAJ |
| description | Abstract Objectives This study evaluated the clinical utility of the Patient-Reported Outcomes Measurement Information System (PROMIS®) by comparing it with objective clinical data and validated health-related quality of life (HRQOL) measures in pediatric Crohn’s disease (CD) patients. Study design Cross-sectional study. Pediatric CD patients (aged 8–17 years) were enrolled prospectively over eight months from an outpatient pediatric gastroenterology center. We assessed the associations between PROMIS® Pediatric short-form measures, demographic and disease-related data, global clinical assessments, and HRQOL measures. A subanalysis according to the PCDAI (remission versus active disease) was also conducted. Results Thirty-one patients (mean age: 15.3; 58% female) with a mean disease duration of 2.7 years were included; 80.6% were in remission or had mild disease. The PROMIS® score was significantly correlated with several factors: age was negatively correlated with the PROMIS® Global Health Scale (r=-0.399; p = 0.026) and Life Satisfaction (r=-0.359; p = 0.047); sex was associated with the PROMIS® Cognitive Function Scale (t = 2.20; p = 0.038), favoring males; and school level was inversely related to the PROMIS® Peer Relationships (F = 3.90; p = 0.003). Clinical assessments also revealed significant correlations between hemoglobin and PROMIS® Global Health (r = 0.356; p = 0.049) and pain interference (r=-0.360; p = 0.046) and between ferritin and PROMIS® Meaning and Purpose (r = 0.435; p = 0.016) and cognitive function (r = 0.450; p = 0.011). Disease activity assessments correlated significantly with multiple PROMIS® measures, with better scores in patients in remission. Treatment changes, particularly corticosteroid treatment, negatively impacted the PROMIS® Anxiety and Life Satisfaction scores. IMPACT-III scores correlated positively with PROMIS® Global Health, Meaning and Purpose, Life Satisfaction, and peer relationships scores and negatively with Depression, Anxiety, Pain interference, and Fatigue scores. Group analysis indicated better PROMIS® scores and HRQOL scores in remission than in active disease remission. Conclusion Consistent with recent evidence, PROMIS® scores reliably reflect disease activity and HRQOL. The meaningful associations with clinical assessment and treatment efficacy reinforce the clinical relevance and utility of PROs in the patient-centered management of pediatric IBD and highlight the importance of self-reports as a gold standard tool for assessing health status. |
| format | Article |
| id | doaj-art-7ec0b92adf5c43df82959dd24c61a79c |
| institution | Kabale University |
| issn | 1477-7525 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Health and Quality of Life Outcomes |
| spelling | doaj-art-7ec0b92adf5c43df82959dd24c61a79c2025-01-05T12:47:14ZengBMCHealth and Quality of Life Outcomes1477-75252024-12-0122111110.1186/s12955-024-02330-2Clinical usefulness of patient-reported-outcome-measurement information system in Pediatric Crohn’s Disease: a cross-sectional studySara Azevedo0Maria Miguel Oliveira1Paulo Nogueira2Ana Isabel Lopes3Gastroenterology Unit, Pediatric Department, Santa Maria University Hospital - CHLN, Academic Medical Centre of LisbonMedical School, University of LisbonMedical School, University of LisbonGastroenterology Unit, Pediatric Department, Santa Maria University Hospital - CHLN, Academic Medical Centre of LisbonAbstract Objectives This study evaluated the clinical utility of the Patient-Reported Outcomes Measurement Information System (PROMIS®) by comparing it with objective clinical data and validated health-related quality of life (HRQOL) measures in pediatric Crohn’s disease (CD) patients. Study design Cross-sectional study. Pediatric CD patients (aged 8–17 years) were enrolled prospectively over eight months from an outpatient pediatric gastroenterology center. We assessed the associations between PROMIS® Pediatric short-form measures, demographic and disease-related data, global clinical assessments, and HRQOL measures. A subanalysis according to the PCDAI (remission versus active disease) was also conducted. Results Thirty-one patients (mean age: 15.3; 58% female) with a mean disease duration of 2.7 years were included; 80.6% were in remission or had mild disease. The PROMIS® score was significantly correlated with several factors: age was negatively correlated with the PROMIS® Global Health Scale (r=-0.399; p = 0.026) and Life Satisfaction (r=-0.359; p = 0.047); sex was associated with the PROMIS® Cognitive Function Scale (t = 2.20; p = 0.038), favoring males; and school level was inversely related to the PROMIS® Peer Relationships (F = 3.90; p = 0.003). Clinical assessments also revealed significant correlations between hemoglobin and PROMIS® Global Health (r = 0.356; p = 0.049) and pain interference (r=-0.360; p = 0.046) and between ferritin and PROMIS® Meaning and Purpose (r = 0.435; p = 0.016) and cognitive function (r = 0.450; p = 0.011). Disease activity assessments correlated significantly with multiple PROMIS® measures, with better scores in patients in remission. Treatment changes, particularly corticosteroid treatment, negatively impacted the PROMIS® Anxiety and Life Satisfaction scores. IMPACT-III scores correlated positively with PROMIS® Global Health, Meaning and Purpose, Life Satisfaction, and peer relationships scores and negatively with Depression, Anxiety, Pain interference, and Fatigue scores. Group analysis indicated better PROMIS® scores and HRQOL scores in remission than in active disease remission. Conclusion Consistent with recent evidence, PROMIS® scores reliably reflect disease activity and HRQOL. The meaningful associations with clinical assessment and treatment efficacy reinforce the clinical relevance and utility of PROs in the patient-centered management of pediatric IBD and highlight the importance of self-reports as a gold standard tool for assessing health status.https://doi.org/10.1186/s12955-024-02330-2PediatricsChildrenHealth-related quality of lifePatient-reported outcomes measurement information system (PROMI)Inflammatory bowel diseaseCrohn’s disease |
| spellingShingle | Sara Azevedo Maria Miguel Oliveira Paulo Nogueira Ana Isabel Lopes Clinical usefulness of patient-reported-outcome-measurement information system in Pediatric Crohn’s Disease: a cross-sectional study Health and Quality of Life Outcomes Pediatrics Children Health-related quality of life Patient-reported outcomes measurement information system (PROMI) Inflammatory bowel disease Crohn’s disease |
| title | Clinical usefulness of patient-reported-outcome-measurement information system in Pediatric Crohn’s Disease: a cross-sectional study |
| title_full | Clinical usefulness of patient-reported-outcome-measurement information system in Pediatric Crohn’s Disease: a cross-sectional study |
| title_fullStr | Clinical usefulness of patient-reported-outcome-measurement information system in Pediatric Crohn’s Disease: a cross-sectional study |
| title_full_unstemmed | Clinical usefulness of patient-reported-outcome-measurement information system in Pediatric Crohn’s Disease: a cross-sectional study |
| title_short | Clinical usefulness of patient-reported-outcome-measurement information system in Pediatric Crohn’s Disease: a cross-sectional study |
| title_sort | clinical usefulness of patient reported outcome measurement information system in pediatric crohn s disease a cross sectional study |
| topic | Pediatrics Children Health-related quality of life Patient-reported outcomes measurement information system (PROMI) Inflammatory bowel disease Crohn’s disease |
| url | https://doi.org/10.1186/s12955-024-02330-2 |
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