Predictive value of hematologic indices in COVID-19 disease outcomes
Introduction: COVID-19 was declared a worldwide concern for public health in January 2020 by the World Health Organization. Most patients manifest mild symptoms. In more severe cases it can lead to sepsis, acute respiratory distress syndrome and other organ dysfunction. Lymphopenia, increased inflam...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Zabansaraye Parsian Novin Mehr Institute
2024-12-01
|
| Series: | Journal of Current Oncology and Medical Sciences |
| Subjects: | |
| Online Access: | https://submission.journalofcoms.com/index.php/JCOMS/article/view/249 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841527834645889024 |
|---|---|
| author | Fatemeh Nejatifar Ali Alavi Foumani Saman Maroufizadeh Bardia Afsharian Zahra Chegini Amir Mohammad Ghanbari |
| author_facet | Fatemeh Nejatifar Ali Alavi Foumani Saman Maroufizadeh Bardia Afsharian Zahra Chegini Amir Mohammad Ghanbari |
| author_sort | Fatemeh Nejatifar |
| collection | DOAJ |
| description | Introduction: COVID-19 was declared a worldwide concern for public health in January 2020 by the World Health Organization. Most patients manifest mild symptoms. In more severe cases it can lead to sepsis, acute respiratory distress syndrome and other organ dysfunction. Lymphopenia, increased inflammatory markers and dysregulated liver enzymes are observed in many patients and is related to higher mortality rates.
Materials and Methods: We evaluated two hundred and sixty-eight patients in this study. All patients had dyspnea, and O2 saturation below 93% and were tested positive for COVID-19 through RT-PCR. Patients’ demographic, clinical and paraclinical information were obtained on admission and disease outcomes were assessed based on these data. The evaluated indices were previously shown to be altered in patients with different disease outcomes.
Results: From a total of 268 included patients, 40% had severe disease, 29% were admitted to ICU, 22% required mechanical ventilation and 24% died during hospitalization. WBC counts, neutrophil counts, NLR, serum LDH activity and serum albumin levels were the most powerful factors in predicting disease outcomes.
Conclusion: COVID-19 disease severity and outcomes were affected by hematologic indices and laboratory results. |
| format | Article |
| id | doaj-art-7eb64b6be4e740dfa125233d4d8ac39f |
| institution | Kabale University |
| issn | 2783-3127 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Zabansaraye Parsian Novin Mehr Institute |
| record_format | Article |
| series | Journal of Current Oncology and Medical Sciences |
| spelling | doaj-art-7eb64b6be4e740dfa125233d4d8ac39f2025-01-15T06:31:02ZengZabansaraye Parsian Novin Mehr InstituteJournal of Current Oncology and Medical Sciences2783-31272024-12-0144945957Predictive value of hematologic indices in COVID-19 disease outcomesFatemeh Nejatifar0Ali Alavi Foumani1Saman Maroufizadeh2Bardia Afsharian3Zahra Chegini4Amir Mohammad Ghanbari5Hematology and Medical Oncology Department, Guilan University of Medical Sciences, Rasht, IranInflammatory Lung Diseases Research Center, Department of Pulmonology, Guilan University of Medical Sciences, Rasht, IranDepartment of Biostatistics and Epidemiology, School of Health, Guilan University of Medical Sciences, Rasht, IranStudent Research Committee, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, IranStudent Research Committee, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, IranStudent Research Committee, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, IranIntroduction: COVID-19 was declared a worldwide concern for public health in January 2020 by the World Health Organization. Most patients manifest mild symptoms. In more severe cases it can lead to sepsis, acute respiratory distress syndrome and other organ dysfunction. Lymphopenia, increased inflammatory markers and dysregulated liver enzymes are observed in many patients and is related to higher mortality rates. Materials and Methods: We evaluated two hundred and sixty-eight patients in this study. All patients had dyspnea, and O2 saturation below 93% and were tested positive for COVID-19 through RT-PCR. Patients’ demographic, clinical and paraclinical information were obtained on admission and disease outcomes were assessed based on these data. The evaluated indices were previously shown to be altered in patients with different disease outcomes. Results: From a total of 268 included patients, 40% had severe disease, 29% were admitted to ICU, 22% required mechanical ventilation and 24% died during hospitalization. WBC counts, neutrophil counts, NLR, serum LDH activity and serum albumin levels were the most powerful factors in predicting disease outcomes. Conclusion: COVID-19 disease severity and outcomes were affected by hematologic indices and laboratory results.https://submission.journalofcoms.com/index.php/JCOMS/article/view/249covid-19neutrophilwhite blood cellneutrophil lymphocyte ratio |
| spellingShingle | Fatemeh Nejatifar Ali Alavi Foumani Saman Maroufizadeh Bardia Afsharian Zahra Chegini Amir Mohammad Ghanbari Predictive value of hematologic indices in COVID-19 disease outcomes Journal of Current Oncology and Medical Sciences covid-19 neutrophil white blood cell neutrophil lymphocyte ratio |
| title | Predictive value of hematologic indices in COVID-19 disease outcomes |
| title_full | Predictive value of hematologic indices in COVID-19 disease outcomes |
| title_fullStr | Predictive value of hematologic indices in COVID-19 disease outcomes |
| title_full_unstemmed | Predictive value of hematologic indices in COVID-19 disease outcomes |
| title_short | Predictive value of hematologic indices in COVID-19 disease outcomes |
| title_sort | predictive value of hematologic indices in covid 19 disease outcomes |
| topic | covid-19 neutrophil white blood cell neutrophil lymphocyte ratio |
| url | https://submission.journalofcoms.com/index.php/JCOMS/article/view/249 |
| work_keys_str_mv | AT fatemehnejatifar predictivevalueofhematologicindicesincovid19diseaseoutcomes AT alialavifoumani predictivevalueofhematologicindicesincovid19diseaseoutcomes AT samanmaroufizadeh predictivevalueofhematologicindicesincovid19diseaseoutcomes AT bardiaafsharian predictivevalueofhematologicindicesincovid19diseaseoutcomes AT zahrachegini predictivevalueofhematologicindicesincovid19diseaseoutcomes AT amirmohammadghanbari predictivevalueofhematologicindicesincovid19diseaseoutcomes |