Diagnostic Utility of Diffusion-Weighted Imaging in Distinguishing Common Pediatric Posterior Fossa Tumors: A Single Center Retrospective Study
Objective: Pediatric posterior fossa tumors pose diagnostic challenges due to their diverse histopathological features and variable clinical presentations. Conventional magnetic resonance imaging (MRI) serves as the initial diagnostic tool; however, additional modalities, such as diffusion-weighted...
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| Format: | Article |
| Language: | English |
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AVES Yayincilik
2024-11-01
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| Series: | Turkish Archives of Pediatrics |
| Online Access: | https://turkarchpediatr.org/en/diagnostic-utility-of-diffusion-weighted-imaging-in-distinguishing-common-pediatric-posterior-fossa-tumors-a-single-center-retrospective-study-131711 |
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| author | Umur Anil Pehlivan Elif Habibe Aktekin Cigdem Yalcin Bermal Hasbay Aylin Gunesli Ozlem Alkan |
| author_facet | Umur Anil Pehlivan Elif Habibe Aktekin Cigdem Yalcin Bermal Hasbay Aylin Gunesli Ozlem Alkan |
| author_sort | Umur Anil Pehlivan |
| collection | DOAJ |
| description | Objective: Pediatric posterior fossa tumors pose diagnostic challenges due to their diverse histopathological features and variable clinical presentations. Conventional magnetic resonance imaging (MRI) serves as the initial diagnostic tool; however, additional modalities, such as diffusion-weighted imaging (DWI), are essential for refining tumor classification. This retrospective single-center study aimed to evaluate the diagnostic utility of apparent diffusion coefficient (ADC) parameters in distinguishing between the most common pediatric posterior fossa tumors.
Materials and Methods: Fifty-nine patients under the age of 18 (27 females and 32 males) with histopathologically diagnosed primary posterior fossa tumors underwent pre-treatment conventional and diffusion MRI. Apparent diffusion coefficient values were measured from solid tumor regions and normal cerebellar parenchyma, with subsequent calculation of tumor/normal cerebellar ADC ratios.
Results: The median ADC values for pilocytic astrocytomas (PAs) were 1786.2 × 10−6 mm2 /s, ependymomas 1144.9 × 10−6 mm2 /s, and for medulloblastomas 666.1 × 10−6 mm2 /s were significantly different (P < .001 for all three). Similarly, the median ADC ratios demonstrated discriminatory potential, with PAs showing the highest ratio (2.46), followed by ependymomas (1.55) and medulloblastomas (0.89) (P < .001 for all three). Receiver operating characteristic analysis revealed distinct ADC cutoffs and ratios for differentiating all tumor types from each other.
Conclusion: Despite limitations, such as a small cohort size and different MRI protocols, our results show that ADC metrics are especially useful for distinguishing between the most common pediatric posterior fossa tumors. We recommend that future studies integrate advanced imaging techniques and larger cohorts to improve diagnostic accuracy. |
| format | Article |
| id | doaj-art-7eb40a387b2b40298f15c0c733f39519 |
| institution | Kabale University |
| issn | 2757-6256 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | AVES Yayincilik |
| record_format | Article |
| series | Turkish Archives of Pediatrics |
| spelling | doaj-art-7eb40a387b2b40298f15c0c733f395192024-11-28T09:33:21ZengAVES YayincilikTurkish Archives of Pediatrics2757-62562024-11-0159656056610.5152/TurkArchPediatr.2024.24154Diagnostic Utility of Diffusion-Weighted Imaging in Distinguishing Common Pediatric Posterior Fossa Tumors: A Single Center Retrospective StudyUmur Anil Pehlivan0Elif Habibe Aktekin1Cigdem Yalcin2 Bermal Hasbay3Aylin Gunesli4Ozlem Alkan5Department of Radiology, Adana Dr. Turgut Noyan Application and Research Center, Baskent University Faculty of Medicine, Adana, TürkiyeDepartment of Pediatric Hematology and Oncology, Adana Dr. Turgut Noyan Application and Research Center, Baskent University Faculty of Medicine, Adana, TürkiyeDepartment of Radiology, Adana Dr. Turgut Noyan Application and Research Center, Baskent University Faculty of Medicine, Adana, TürkiyeDepartment of Pathology, Adana Dr. Turgut Noyan Application and Research Center, Baskent University Faculty of Medicine, Adana, TürkiyeDepartment of Radiology, Adana Dr. Turgut Noyan Application and Research Center, Baskent University Faculty of Medicine, Adana, TürkiyeDepartment of Radiology, Adana Dr. Turgut Noyan Application and Research Center, Baskent University Faculty of Medicine, Adana, TürkiyeObjective: Pediatric posterior fossa tumors pose diagnostic challenges due to their diverse histopathological features and variable clinical presentations. Conventional magnetic resonance imaging (MRI) serves as the initial diagnostic tool; however, additional modalities, such as diffusion-weighted imaging (DWI), are essential for refining tumor classification. This retrospective single-center study aimed to evaluate the diagnostic utility of apparent diffusion coefficient (ADC) parameters in distinguishing between the most common pediatric posterior fossa tumors. Materials and Methods: Fifty-nine patients under the age of 18 (27 females and 32 males) with histopathologically diagnosed primary posterior fossa tumors underwent pre-treatment conventional and diffusion MRI. Apparent diffusion coefficient values were measured from solid tumor regions and normal cerebellar parenchyma, with subsequent calculation of tumor/normal cerebellar ADC ratios. Results: The median ADC values for pilocytic astrocytomas (PAs) were 1786.2 × 10−6 mm2 /s, ependymomas 1144.9 × 10−6 mm2 /s, and for medulloblastomas 666.1 × 10−6 mm2 /s were significantly different (P < .001 for all three). Similarly, the median ADC ratios demonstrated discriminatory potential, with PAs showing the highest ratio (2.46), followed by ependymomas (1.55) and medulloblastomas (0.89) (P < .001 for all three). Receiver operating characteristic analysis revealed distinct ADC cutoffs and ratios for differentiating all tumor types from each other. Conclusion: Despite limitations, such as a small cohort size and different MRI protocols, our results show that ADC metrics are especially useful for distinguishing between the most common pediatric posterior fossa tumors. We recommend that future studies integrate advanced imaging techniques and larger cohorts to improve diagnostic accuracy.https://turkarchpediatr.org/en/diagnostic-utility-of-diffusion-weighted-imaging-in-distinguishing-common-pediatric-posterior-fossa-tumors-a-single-center-retrospective-study-131711 |
| spellingShingle | Umur Anil Pehlivan Elif Habibe Aktekin Cigdem Yalcin Bermal Hasbay Aylin Gunesli Ozlem Alkan Diagnostic Utility of Diffusion-Weighted Imaging in Distinguishing Common Pediatric Posterior Fossa Tumors: A Single Center Retrospective Study Turkish Archives of Pediatrics |
| title | Diagnostic Utility of Diffusion-Weighted Imaging in Distinguishing Common Pediatric Posterior Fossa Tumors: A Single Center Retrospective Study |
| title_full | Diagnostic Utility of Diffusion-Weighted Imaging in Distinguishing Common Pediatric Posterior Fossa Tumors: A Single Center Retrospective Study |
| title_fullStr | Diagnostic Utility of Diffusion-Weighted Imaging in Distinguishing Common Pediatric Posterior Fossa Tumors: A Single Center Retrospective Study |
| title_full_unstemmed | Diagnostic Utility of Diffusion-Weighted Imaging in Distinguishing Common Pediatric Posterior Fossa Tumors: A Single Center Retrospective Study |
| title_short | Diagnostic Utility of Diffusion-Weighted Imaging in Distinguishing Common Pediatric Posterior Fossa Tumors: A Single Center Retrospective Study |
| title_sort | diagnostic utility of diffusion weighted imaging in distinguishing common pediatric posterior fossa tumors a single center retrospective study |
| url | https://turkarchpediatr.org/en/diagnostic-utility-of-diffusion-weighted-imaging-in-distinguishing-common-pediatric-posterior-fossa-tumors-a-single-center-retrospective-study-131711 |
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