Adaptive Mechanisms of Mycobacterium tuberculosis: Role of fbiC Mutations in Dormancy and Survival
This review examines the impact of F420 biosynthesis protein C (fbiC) mutations in Mycobacterium tuberculosis (Mtb) and their influence on the bacterium’s dormancy mechanisms. The potential role of fbiC mutations and functional impairments in the persistence of Mtb is emphasized. Tuberculosis (TB) b...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | International Journal of Mycobacteriology |
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| Online Access: | https://journals.lww.com/10.4103/ijmy.ijmy_198_24 |
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| author | Parissa Farnia Mohsen Maleknia Poopak Farnia Jalaledin Ghanavi |
| author_facet | Parissa Farnia Mohsen Maleknia Poopak Farnia Jalaledin Ghanavi |
| author_sort | Parissa Farnia |
| collection | DOAJ |
| description | This review examines the impact of F420 biosynthesis protein C (fbiC) mutations in Mycobacterium tuberculosis (Mtb) and their influence on the bacterium’s dormancy mechanisms. The potential role of fbiC mutations and functional impairments in the persistence of Mtb is emphasized. Tuberculosis (TB) bacilli can enter a dormant state with minimal metabolic activity, allowing them to conserve resources and survive in low-nutrient, low-oxygen environments for extended periods. While the fbiC gene contributes to dormancy, Mtb can achieve this state through multiple genetic and metabolic pathways, suggesting that it may still undergo dormancy even with functional impairments in fbiC. In this review, we utilized several scientific databases, including PubMed, Web of Science, and Google Scholar, and set of key search terms including “fbiC gene,” “F420 Biosynthesis,” “Mycobacterium tuberculosis,” “Dormancy,” and “Drug Resistance” to highlight the significance of the fbiC gene in regulating dormancy and explore how Mtb compensates for fbiC dysfunction through various metabolic adaptations. |
| format | Article |
| id | doaj-art-7ead81536ee94004a1c38f6dfabee317 |
| institution | Kabale University |
| issn | 2212-5531 2212-554X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Mycobacteriology |
| spelling | doaj-art-7ead81536ee94004a1c38f6dfabee3172025-01-07T06:19:07ZengWolters Kluwer Medknow PublicationsInternational Journal of Mycobacteriology2212-55312212-554X2024-12-0113435536110.4103/ijmy.ijmy_198_24Adaptive Mechanisms of Mycobacterium tuberculosis: Role of fbiC Mutations in Dormancy and SurvivalParissa FarniaMohsen MalekniaPoopak FarniaJalaledin GhanaviThis review examines the impact of F420 biosynthesis protein C (fbiC) mutations in Mycobacterium tuberculosis (Mtb) and their influence on the bacterium’s dormancy mechanisms. The potential role of fbiC mutations and functional impairments in the persistence of Mtb is emphasized. Tuberculosis (TB) bacilli can enter a dormant state with minimal metabolic activity, allowing them to conserve resources and survive in low-nutrient, low-oxygen environments for extended periods. While the fbiC gene contributes to dormancy, Mtb can achieve this state through multiple genetic and metabolic pathways, suggesting that it may still undergo dormancy even with functional impairments in fbiC. In this review, we utilized several scientific databases, including PubMed, Web of Science, and Google Scholar, and set of key search terms including “fbiC gene,” “F420 Biosynthesis,” “Mycobacterium tuberculosis,” “Dormancy,” and “Drug Resistance” to highlight the significance of the fbiC gene in regulating dormancy and explore how Mtb compensates for fbiC dysfunction through various metabolic adaptations.https://journals.lww.com/10.4103/ijmy.ijmy_198_24dormancydrug resistancef420 biosynthesisf420 biosynthesis protein c genemycobacterium tuberculosis |
| spellingShingle | Parissa Farnia Mohsen Maleknia Poopak Farnia Jalaledin Ghanavi Adaptive Mechanisms of Mycobacterium tuberculosis: Role of fbiC Mutations in Dormancy and Survival International Journal of Mycobacteriology dormancy drug resistance f420 biosynthesis f420 biosynthesis protein c gene mycobacterium tuberculosis |
| title | Adaptive Mechanisms of Mycobacterium tuberculosis: Role of fbiC Mutations in Dormancy and Survival |
| title_full | Adaptive Mechanisms of Mycobacterium tuberculosis: Role of fbiC Mutations in Dormancy and Survival |
| title_fullStr | Adaptive Mechanisms of Mycobacterium tuberculosis: Role of fbiC Mutations in Dormancy and Survival |
| title_full_unstemmed | Adaptive Mechanisms of Mycobacterium tuberculosis: Role of fbiC Mutations in Dormancy and Survival |
| title_short | Adaptive Mechanisms of Mycobacterium tuberculosis: Role of fbiC Mutations in Dormancy and Survival |
| title_sort | adaptive mechanisms of mycobacterium tuberculosis role of fbic mutations in dormancy and survival |
| topic | dormancy drug resistance f420 biosynthesis f420 biosynthesis protein c gene mycobacterium tuberculosis |
| url | https://journals.lww.com/10.4103/ijmy.ijmy_198_24 |
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