Subtyping colorectal cancer based on septic shock-associated genes: prognosis and immune characteristics
BackgroundSepsis and colorectal cancer (CRC) are leading causes of death. Given their mutual dependence for susceptibility, we used bioinformatics to explore potential connections between septic shock (SS) and CRC.MethodsWe identified 452 co-expressed genes between SS-related differential expression...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2024.1468424/full |
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| author | Jinkai Zhao Jiaan Chen Jiancheng Zhang Xuming Pan Buhai Xu Jinli Miao Wenmin Wang Guangjun Jin |
| author_facet | Jinkai Zhao Jiaan Chen Jiancheng Zhang Xuming Pan Buhai Xu Jinli Miao Wenmin Wang Guangjun Jin |
| author_sort | Jinkai Zhao |
| collection | DOAJ |
| description | BackgroundSepsis and colorectal cancer (CRC) are leading causes of death. Given their mutual dependence for susceptibility, we used bioinformatics to explore potential connections between septic shock (SS) and CRC.MethodsWe identified 452 co-expressed genes between SS-related differential expression genes (SS-DEGs) and CRC patient-expressed genes (TCGA-CRC genes). CRC samples were categorized into two cluster subgroups through hierarchical clustering. We then compared the prognosis and immune landscapes of the two cluster subgroups through survival analysis, immune microenvironment analysis, and immune therapy response evaluation.ResultsClustering analysis of the 452 CRC patient-expressed SS-DEGs identified two subtypes: SS-like CRC (SL-CRC) and non-SS-like CRC (NSL-CRC). There were no significant differences in overall survival between the CRC subtypes. However, the subtypes displayed significant differences in immune score, stromal score, and ESTIMATE score. Based on immune therapy databases, there were also significant differences in responses to anti-CTLA-4 and anti-PD-1 immune checkpoint inhibitors between the subtypes.ConclusionOur study reveals significant differences in the immune microenvironment and immune therapy responses between SL-CRC and NSL-CRC subtypes. These findings provide a foundation for identifying new therapeutic targets and developing personalized treatment strategies for specific CRC subtypes. |
| format | Article |
| id | doaj-art-7e9835be6c0d4b7bb5b2adc92b79d62d |
| institution | Kabale University |
| issn | 1664-8021 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj-art-7e9835be6c0d4b7bb5b2adc92b79d62d2024-11-15T06:13:13ZengFrontiers Media S.A.Frontiers in Genetics1664-80212024-11-011510.3389/fgene.2024.14684241468424Subtyping colorectal cancer based on septic shock-associated genes: prognosis and immune characteristicsJinkai Zhao0Jiaan Chen1Jiancheng Zhang2Xuming Pan3Buhai Xu4Jinli Miao5Wenmin Wang6Guangjun Jin7The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaThe Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Emergency, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Emergency, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Emergency, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaThe Yangtze River Delta Biological Medicine Research and Development Center of Zhejiang Province, Yangtze Delta Region Institution of Tsinghua University, Hangzhou, Zhejiang, ChinaThe Yangtze River Delta Biological Medicine Research and Development Center of Zhejiang Province, Yangtze Delta Region Institution of Tsinghua University, Hangzhou, Zhejiang, ChinaDepartment of Emergency, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaBackgroundSepsis and colorectal cancer (CRC) are leading causes of death. Given their mutual dependence for susceptibility, we used bioinformatics to explore potential connections between septic shock (SS) and CRC.MethodsWe identified 452 co-expressed genes between SS-related differential expression genes (SS-DEGs) and CRC patient-expressed genes (TCGA-CRC genes). CRC samples were categorized into two cluster subgroups through hierarchical clustering. We then compared the prognosis and immune landscapes of the two cluster subgroups through survival analysis, immune microenvironment analysis, and immune therapy response evaluation.ResultsClustering analysis of the 452 CRC patient-expressed SS-DEGs identified two subtypes: SS-like CRC (SL-CRC) and non-SS-like CRC (NSL-CRC). There were no significant differences in overall survival between the CRC subtypes. However, the subtypes displayed significant differences in immune score, stromal score, and ESTIMATE score. Based on immune therapy databases, there were also significant differences in responses to anti-CTLA-4 and anti-PD-1 immune checkpoint inhibitors between the subtypes.ConclusionOur study reveals significant differences in the immune microenvironment and immune therapy responses between SL-CRC and NSL-CRC subtypes. These findings provide a foundation for identifying new therapeutic targets and developing personalized treatment strategies for specific CRC subtypes.https://www.frontiersin.org/articles/10.3389/fgene.2024.1468424/fullclusteringcolorectal cancerimmuneseptic shocksepsis |
| spellingShingle | Jinkai Zhao Jiaan Chen Jiancheng Zhang Xuming Pan Buhai Xu Jinli Miao Wenmin Wang Guangjun Jin Subtyping colorectal cancer based on septic shock-associated genes: prognosis and immune characteristics Frontiers in Genetics clustering colorectal cancer immune septic shock sepsis |
| title | Subtyping colorectal cancer based on septic shock-associated genes: prognosis and immune characteristics |
| title_full | Subtyping colorectal cancer based on septic shock-associated genes: prognosis and immune characteristics |
| title_fullStr | Subtyping colorectal cancer based on septic shock-associated genes: prognosis and immune characteristics |
| title_full_unstemmed | Subtyping colorectal cancer based on septic shock-associated genes: prognosis and immune characteristics |
| title_short | Subtyping colorectal cancer based on septic shock-associated genes: prognosis and immune characteristics |
| title_sort | subtyping colorectal cancer based on septic shock associated genes prognosis and immune characteristics |
| topic | clustering colorectal cancer immune septic shock sepsis |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2024.1468424/full |
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