SLC38A5 suppresses ferroptosis through glutamine-mediated activation of the PI3K/AKT/mTOR signaling in osteosarcoma

SLC38A5 suppresses ferroptosis through glutamine-mediated activation of the PI3K/AKT/mTOR signaling in osteosarcoma

Abstract Background Solute carrier family 38 member 5 (SLC38A5) is an amino acid transporter that plays a significant role in various cellular biological processes and may be involved in regulating the progression of tumors However, its function and underlying mechanism in osteosarcoma remain unexpl...

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Bibliographic Details
Main Authors: Xinghan Huang, Kezhou Xia, Zhun Wei, Wenda Liu, Zicheng Wei, Weichun Guo
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Translational Medicine
Subjects:
Osteosarcoma
SLC38A5
PI3K/AKT/mTOR pathway
glutamine
ferroptosis
Online Access:https://doi.org/10.1186/s12967-024-05803-6
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