Evaluation of Periodontal Wound Healing with Human Placental Extract as an Adjunct to Scaling and Root Planing – A Randomized Controlled Clinico-Histological Trial
Aim: The present study is aimed to assess the clinical and histological evaluation of human placental extract (Placentrex®) as an adjunct to scaling and root planing in Stage III Grade A periodontitis. Methods: Forty sites in twelve, stage III Grade A periodontitis patients, were randomly assigned i...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-11-01
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| Series: | Indian Journal of Dental Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijdr.ijdr_135_23 |
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| Summary: | Aim:
The present study is aimed to assess the clinical and histological evaluation of human placental extract (Placentrex®) as an adjunct to scaling and root planing in Stage III Grade A periodontitis.
Methods:
Forty sites in twelve, stage III Grade A periodontitis patients, were randomly assigned into Group I (Test) and Group II (Control). Plaque index (PI), gingival index (GI), probing pocket depth (PPD), and clinical attachment level (CAL) were recorded, and curettage samples were collected in both groups for histological evaluation of collagen density (pixels) at baseline and one month.
Results:
Significant reduction in PI and GI was observed within the groups at baseline and one month. Probing pocket depth at the end of one month was 3.55 ± 0.83 in Group I and 2.50 ± 0.83 in Group II. The gain in clinical attachment level was 2.55 ± 0.83 in Group I and 1.65 ± 0.59 in Group II. PPD and CAL are better in Group I but could not reach statistical significance. Collagen density (pixels) at the end of one month histologically was 2884.9 ± 1386 in Group I and 447.9 ± 244.6 in Group II which were statistically significant (P < 0.05*).
Conclusions:
Local drug delivery of human placental extract played a significant role in managing Stage III Grade A periodontitis, especially as an adjunct to scaling and root planing. |
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| ISSN: | 0970-9290 1998-3603 |