Association between rosacea and helicobacter pylori infection: A meta-analysis.
<h4>Background and objectives</h4>The potential association between rosacea and a heightened prevalence of Helicobacter pylori (HP) infection has been previously suggested. However, existing studies offer inconsistent results. This systematic review and meta-analysis aimed to elucidate t...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0301703&type=printable |
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| author | Ying Gao Xiao-Jing Yang Yun Zhu Ming Yang Fei Gu |
| author_facet | Ying Gao Xiao-Jing Yang Yun Zhu Ming Yang Fei Gu |
| author_sort | Ying Gao |
| collection | DOAJ |
| description | <h4>Background and objectives</h4>The potential association between rosacea and a heightened prevalence of Helicobacter pylori (HP) infection has been previously suggested. However, existing studies offer inconsistent results. This systematic review and meta-analysis aimed to elucidate the relationship between rosacea and HP infection.<h4>Methods</h4>We conducted comprehensive searches of PubMed, Embase, and Web of Science databases to identify relevant observational studies for our investigation. We utilized the random-effects model to aggregate the data to address the potential influence of heterogeneity among the studies on the outcome.<h4>Results</h4>Our analysis incorporated twenty-five datasets from 23 case-control and cross-sectional studies, encompassing 51,054 rosacea patients and 4,709,074 controls without skin disease. The pooled results revealed a significantly higher prevalence of HP infection in individuals with rosacea compared to controls (odds ratio [OR]: 1.51, 95% confidence interval [CI]: 1.17-1.95, p<0.001; I2 = 79%). Subgroup analysis indicated an increased prevalence of HP infection in rosacea studies that utilized one (OR: 1.72, 95% CI: 1.11-2.66, p = 0.02; I2 = 76%) or more tests for HP infection (OR: 2.26, 95% CI: 1.29-3.98, p = 0.005; I2 = 56%). However, this association was not observed in population-based studies that determined HP infection based on prescription records for HP eradication drugs (OR: 0.90, 95% CI: 0.76-1.07, p = 0.024; I2 = 54%).<h4>Conclusion</h4>Rosacea may be significantly associated with a higher prevalence of HP infection. High-quality prospective studies with delicately controlled confounding factors are needed to determine if HP infection is a risk factor for rosacea. |
| format | Article |
| id | doaj-art-7e37723e4b9d4fca9dec695eb04dd9e8 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-7e37723e4b9d4fca9dec695eb04dd9e82024-12-13T05:31:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01194e030170310.1371/journal.pone.0301703Association between rosacea and helicobacter pylori infection: A meta-analysis.Ying GaoXiao-Jing YangYun ZhuMing YangFei Gu<h4>Background and objectives</h4>The potential association between rosacea and a heightened prevalence of Helicobacter pylori (HP) infection has been previously suggested. However, existing studies offer inconsistent results. This systematic review and meta-analysis aimed to elucidate the relationship between rosacea and HP infection.<h4>Methods</h4>We conducted comprehensive searches of PubMed, Embase, and Web of Science databases to identify relevant observational studies for our investigation. We utilized the random-effects model to aggregate the data to address the potential influence of heterogeneity among the studies on the outcome.<h4>Results</h4>Our analysis incorporated twenty-five datasets from 23 case-control and cross-sectional studies, encompassing 51,054 rosacea patients and 4,709,074 controls without skin disease. The pooled results revealed a significantly higher prevalence of HP infection in individuals with rosacea compared to controls (odds ratio [OR]: 1.51, 95% confidence interval [CI]: 1.17-1.95, p<0.001; I2 = 79%). Subgroup analysis indicated an increased prevalence of HP infection in rosacea studies that utilized one (OR: 1.72, 95% CI: 1.11-2.66, p = 0.02; I2 = 76%) or more tests for HP infection (OR: 2.26, 95% CI: 1.29-3.98, p = 0.005; I2 = 56%). However, this association was not observed in population-based studies that determined HP infection based on prescription records for HP eradication drugs (OR: 0.90, 95% CI: 0.76-1.07, p = 0.024; I2 = 54%).<h4>Conclusion</h4>Rosacea may be significantly associated with a higher prevalence of HP infection. High-quality prospective studies with delicately controlled confounding factors are needed to determine if HP infection is a risk factor for rosacea.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0301703&type=printable |
| spellingShingle | Ying Gao Xiao-Jing Yang Yun Zhu Ming Yang Fei Gu Association between rosacea and helicobacter pylori infection: A meta-analysis. PLoS ONE |
| title | Association between rosacea and helicobacter pylori infection: A meta-analysis. |
| title_full | Association between rosacea and helicobacter pylori infection: A meta-analysis. |
| title_fullStr | Association between rosacea and helicobacter pylori infection: A meta-analysis. |
| title_full_unstemmed | Association between rosacea and helicobacter pylori infection: A meta-analysis. |
| title_short | Association between rosacea and helicobacter pylori infection: A meta-analysis. |
| title_sort | association between rosacea and helicobacter pylori infection a meta analysis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0301703&type=printable |
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