Hepatic safety of pretomanid- and pyrazinamide-containing regimens in TB Alliance clinical trials

Hepatic safety of pretomanid- and pyrazinamide-containing regimens in TB Alliance clinical trials

BACKGROUND: In STAND and SimpliciTB, clinical trials for drug-susceptible TB, regimens containing pretomanid, pyrazinamide, and other agents (PaZX) had more hepatotoxicity than the standard-of-care regimen of isoniazid, rifampicin, pyrazinamide, and ethambutol (HRZE). In Nix-TB and ZeNix, clinical t...

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Bibliographic Details
Main Authors: J. Nedelman, M. Li, M. Olugbosi, R. Bruning-Barry, J. Ambroso, M. Cevik, S. Gillespie, D.J. Sloan, M. Beumont, E. Sun
Format: Article
Language:English
Published: International Union Against Tuberculosis and Lung Disease (The Union) 2025-08-01
Series:IJTLD Open
Subjects:
tuberculosis
hepatotoxicity
bedaquiline
linezolid
moxifloxacin
Online Access:https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2025/00000002/00000008/art00004
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