OPTIMIZATION OF THE METHOD FOR OBTAINING NANOCAPSULES, DEVELOPMENT OF THE METHODS OF DETERMINING THE DEGREE OF CINNARIZINE INCLUSION IN A PROLONGED DOSAGE FORM BASED ON POLY-D, L-LACTID-CO-GLICOLIDE, AND ITS VALIDATION

OPTIMIZATION OF THE METHOD FOR OBTAINING NANOCAPSULES, DEVELOPMENT OF THE METHODS OF DETERMINING THE DEGREE OF CINNARIZINE INCLUSION IN A PROLONGED DOSAGE FORM BASED ON POLY-D, L-LACTID-CO-GLICOLIDE, AND ITS VALIDATION

Common pathologies of the cardiovascular system are cerebrovascular disorders, for which cinnarizine is prescribed. An innovative, prolonged nanocapsule dosage form based on poly-D, L-lactide-co-glycolide (PLGA) has been developed.The aim of the research was improvement of the technology and develop...

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Bibliographic Details
Main Authors: M. V. Sorokoumova, N. V. Blagorazumnaya, V. A. Kompantsev, L. I. Shcherbakova, N. S. Zyablitseva, Yu. G. Medvetskaya, T. M. Vasina, K. A. Miroshnichenko
Format: Article
Language:Russian
Published: Volgograd State Medical University, Pyatigorsk Medical and Pharmaceutical Institute 2019-07-01
Series:Фармация и фармакология (Пятигорск)
Subjects:
cinnarizine
poly-d
l-lactide-co-glycolide
microparticles
degree of incorporation
uv spectrometry
Online Access:https://www.pharmpharm.ru/jour/article/view/397
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