Resting‐State Electroencephalogram Complexity Is Associated With Oral Ketamine Treatment Response: A Bayesian Analysis of Lempel–Ziv Complexity and Multiscale Entropy
ABSTRACT Introduction Subanesthetic doses of ketamine are a promising novel treatment for suicidality; however, the evidence for predictive biomarkers is sparse. Recently, measures of complexity, including Lempel–Ziv complexity (LZC) and multiscale entropy (MSE), have been implicated in ketamine...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-11-01
|
| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.70166 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846150541160218624 |
|---|---|
| author | Jules S. Mitchell Toomas E. Anijärv Adem T. Can Megan Dutton Daniel F. Hermens Jim Lagopoulos |
| author_facet | Jules S. Mitchell Toomas E. Anijärv Adem T. Can Megan Dutton Daniel F. Hermens Jim Lagopoulos |
| author_sort | Jules S. Mitchell |
| collection | DOAJ |
| description | ABSTRACT Introduction Subanesthetic doses of ketamine are a promising novel treatment for suicidality; however, the evidence for predictive biomarkers is sparse. Recently, measures of complexity, including Lempel–Ziv complexity (LZC) and multiscale entropy (MSE), have been implicated in ketamine's therapeutic action. We evaluated electroencephalogram (EEG)‐derived LZC and MSE differences between responders and nonresponders to oral ketamine treatment. Methods A total of 31 participants received six single, weekly (titrated) doses of oral racemic ketamine (0.5–3 mg/kg) and underwent EEG scans at baseline (Week 0), post‐treatment (Week 6), and follow‐up (Week 10). Resting‐state (eyes closed and open) recordings were processed in EEGLAB, and complexity metrics were extracted using the Neurokit2 package. Participants were designated responders or nonresponders by clinical response (Beck Suicide Scale [BSS] score reduction of ≥ 50% from baseline to the respective timepoint or score ≤ 6) and then compared in terms of complexity across resting‐state conditions and time. Results Employing a Bayesian mixed effects model, we found strong evidence that LZC was higher in the eyes‐open compared to eyes‐closed condition, as were MSE scales 1–3. At a global level, responders displayed elevated eyes‐open baseline complexity compared to nonresponders, with these values decreasing from baseline to post‐treatment (Week 6) in responders only. Exploratory analyses revealed that the elevated baseline eyes‐open LZC in responders was spatially localized to the left frontal lobe (F1, AF3, FC1, and F3). Conclusion EEG‐complexity metrics may be sensitive biomarkers for evaluating and predicting oral ketamine treatment response, with the left prefrontal cortex bein a possible treatment response region. |
| format | Article |
| id | doaj-art-7de1eef21e3549cb92305a3c9fefd0c3 |
| institution | Kabale University |
| issn | 2162-3279 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-7de1eef21e3549cb92305a3c9fefd0c32024-11-28T14:22:33ZengWileyBrain and Behavior2162-32792024-11-011411n/an/a10.1002/brb3.70166Resting‐State Electroencephalogram Complexity Is Associated With Oral Ketamine Treatment Response: A Bayesian Analysis of Lempel–Ziv Complexity and Multiscale EntropyJules S. Mitchell0Toomas E. Anijärv1Adem T. Can2Megan Dutton3Daniel F. Hermens4Jim Lagopoulos5Thompson Institute University of Sunshine Coast Birtinya Queensland AustraliaThompson Institute University of Sunshine Coast Birtinya Queensland AustraliaThompson Institute University of Sunshine Coast Birtinya Queensland AustraliaThompson Institute University of Sunshine Coast Birtinya Queensland AustraliaThompson Institute University of Sunshine Coast Birtinya Queensland AustraliaThompson Brain & Mind Healthcare Birtinya Queensland AustraliaABSTRACT Introduction Subanesthetic doses of ketamine are a promising novel treatment for suicidality; however, the evidence for predictive biomarkers is sparse. Recently, measures of complexity, including Lempel–Ziv complexity (LZC) and multiscale entropy (MSE), have been implicated in ketamine's therapeutic action. We evaluated electroencephalogram (EEG)‐derived LZC and MSE differences between responders and nonresponders to oral ketamine treatment. Methods A total of 31 participants received six single, weekly (titrated) doses of oral racemic ketamine (0.5–3 mg/kg) and underwent EEG scans at baseline (Week 0), post‐treatment (Week 6), and follow‐up (Week 10). Resting‐state (eyes closed and open) recordings were processed in EEGLAB, and complexity metrics were extracted using the Neurokit2 package. Participants were designated responders or nonresponders by clinical response (Beck Suicide Scale [BSS] score reduction of ≥ 50% from baseline to the respective timepoint or score ≤ 6) and then compared in terms of complexity across resting‐state conditions and time. Results Employing a Bayesian mixed effects model, we found strong evidence that LZC was higher in the eyes‐open compared to eyes‐closed condition, as were MSE scales 1–3. At a global level, responders displayed elevated eyes‐open baseline complexity compared to nonresponders, with these values decreasing from baseline to post‐treatment (Week 6) in responders only. Exploratory analyses revealed that the elevated baseline eyes‐open LZC in responders was spatially localized to the left frontal lobe (F1, AF3, FC1, and F3). Conclusion EEG‐complexity metrics may be sensitive biomarkers for evaluating and predicting oral ketamine treatment response, with the left prefrontal cortex bein a possible treatment response region.https://doi.org/10.1002/brb3.70166complexityelectroencephalogramketaminesuicidality |
| spellingShingle | Jules S. Mitchell Toomas E. Anijärv Adem T. Can Megan Dutton Daniel F. Hermens Jim Lagopoulos Resting‐State Electroencephalogram Complexity Is Associated With Oral Ketamine Treatment Response: A Bayesian Analysis of Lempel–Ziv Complexity and Multiscale Entropy Brain and Behavior complexity electroencephalogram ketamine suicidality |
| title | Resting‐State Electroencephalogram Complexity Is Associated With Oral Ketamine Treatment Response: A Bayesian Analysis of Lempel–Ziv Complexity and Multiscale Entropy |
| title_full | Resting‐State Electroencephalogram Complexity Is Associated With Oral Ketamine Treatment Response: A Bayesian Analysis of Lempel–Ziv Complexity and Multiscale Entropy |
| title_fullStr | Resting‐State Electroencephalogram Complexity Is Associated With Oral Ketamine Treatment Response: A Bayesian Analysis of Lempel–Ziv Complexity and Multiscale Entropy |
| title_full_unstemmed | Resting‐State Electroencephalogram Complexity Is Associated With Oral Ketamine Treatment Response: A Bayesian Analysis of Lempel–Ziv Complexity and Multiscale Entropy |
| title_short | Resting‐State Electroencephalogram Complexity Is Associated With Oral Ketamine Treatment Response: A Bayesian Analysis of Lempel–Ziv Complexity and Multiscale Entropy |
| title_sort | resting state electroencephalogram complexity is associated with oral ketamine treatment response a bayesian analysis of lempel ziv complexity and multiscale entropy |
| topic | complexity electroencephalogram ketamine suicidality |
| url | https://doi.org/10.1002/brb3.70166 |
| work_keys_str_mv | AT julessmitchell restingstateelectroencephalogramcomplexityisassociatedwithoralketaminetreatmentresponseabayesiananalysisoflempelzivcomplexityandmultiscaleentropy AT toomaseanijarv restingstateelectroencephalogramcomplexityisassociatedwithoralketaminetreatmentresponseabayesiananalysisoflempelzivcomplexityandmultiscaleentropy AT ademtcan restingstateelectroencephalogramcomplexityisassociatedwithoralketaminetreatmentresponseabayesiananalysisoflempelzivcomplexityandmultiscaleentropy AT megandutton restingstateelectroencephalogramcomplexityisassociatedwithoralketaminetreatmentresponseabayesiananalysisoflempelzivcomplexityandmultiscaleentropy AT danielfhermens restingstateelectroencephalogramcomplexityisassociatedwithoralketaminetreatmentresponseabayesiananalysisoflempelzivcomplexityandmultiscaleentropy AT jimlagopoulos restingstateelectroencephalogramcomplexityisassociatedwithoralketaminetreatmentresponseabayesiananalysisoflempelzivcomplexityandmultiscaleentropy |