European standard clinical practice recommendations for paediatric high-grade gliomas
Paediatric high-grade gliomas (pedHGGs) are highly invasive brain tumours accounting for approximately 15 % of all central nervous system (CNS) tumours in children and adolescents. The outcome for these tumours is generally poor with 5-year survival rates of less than 20 %. Despite improved biologic...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | EJC Paediatric Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772610X24000709 |
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| author | Elwira Szychot Géraldine Giraud Darren Hargrave Dannis van Vuurden Jacques Grill Veronica Biassoni Maura Massimo André O. Von Büren Rejin Kebudi Maria João Gil-da-Costa Sophie Veldhuijzen van Zanten Simon Bailey Michael Karremann Stephanie Bolle Thankamma Ajithkumar Mechthild Krause Yasmin Lassen-Ramshad Geert Janssens Giovanni Morana Ulrike Löbel Shivaram Avula Brigitte Bison Maarten Lequin Kristian Aquilina Ulrich Thomale Pelle Nilsson Sami Bui-Quy Abu Hamdeh Torsten Pietsch Pascale Varlet Thomas S. Jacques Pieter Wesseling David Jones Uri Tabori Anirban Das David Mulligan Francesca Kozmann Christof M. Kramm |
| author_facet | Elwira Szychot Géraldine Giraud Darren Hargrave Dannis van Vuurden Jacques Grill Veronica Biassoni Maura Massimo André O. Von Büren Rejin Kebudi Maria João Gil-da-Costa Sophie Veldhuijzen van Zanten Simon Bailey Michael Karremann Stephanie Bolle Thankamma Ajithkumar Mechthild Krause Yasmin Lassen-Ramshad Geert Janssens Giovanni Morana Ulrike Löbel Shivaram Avula Brigitte Bison Maarten Lequin Kristian Aquilina Ulrich Thomale Pelle Nilsson Sami Bui-Quy Abu Hamdeh Torsten Pietsch Pascale Varlet Thomas S. Jacques Pieter Wesseling David Jones Uri Tabori Anirban Das David Mulligan Francesca Kozmann Christof M. Kramm |
| author_sort | Elwira Szychot |
| collection | DOAJ |
| description | Paediatric high-grade gliomas (pedHGGs) are highly invasive brain tumours accounting for approximately 15 % of all central nervous system (CNS) tumours in children and adolescents. The outcome for these tumours is generally poor with 5-year survival rates of less than 20 %. Despite improved biological insights into pedHGGs and the promise of more effective therapies, little progress has been made in the effective treatment and the outcome of these tumours over the last four decades. Much of the evidence for the use of chemotherapy in pedHGGs is extrapolated from adult data, and the evidence for its use in the paediatric population is still weak. This guideline was written by members of the SIOPE HGG Working Group as part of the European Standard Clinical Practice (ESCP) Project. The guideline aims to integrate available evidence-based and expert opinion-based information to assist healthcare professionals in the management of pedHGGs and in an attempt to provide equity in healthcare reflecting the varying resources of each European country. |
| format | Article |
| id | doaj-art-7dde28fa49ac4e54b05f8ed0ca5953c6 |
| institution | Kabale University |
| issn | 2772-610X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EJC Paediatric Oncology |
| spelling | doaj-art-7dde28fa49ac4e54b05f8ed0ca5953c62025-01-05T04:28:52ZengElsevierEJC Paediatric Oncology2772-610X2025-06-015100210European standard clinical practice recommendations for paediatric high-grade gliomasElwira Szychot0Géraldine Giraud1Darren Hargrave2Dannis van Vuurden3Jacques Grill4Veronica Biassoni5Maura Massimo6André O. Von Büren7Rejin Kebudi8Maria João Gil-da-Costa9Sophie Veldhuijzen van Zanten10Simon Bailey11Michael Karremann12Stephanie Bolle13Thankamma Ajithkumar14Mechthild Krause15Yasmin Lassen-Ramshad16Geert Janssens17Giovanni Morana18Ulrike Löbel19Shivaram Avula20Brigitte Bison21Maarten Lequin22Kristian Aquilina23Ulrich Thomale24Pelle Nilsson25Sami Bui-Quy Abu Hamdeh26Torsten Pietsch27Pascale Varlet28Thomas S. Jacques29Pieter Wesseling30David Jones31Uri Tabori32Anirban Das33David Mulligan34Francesca Kozmann35Christof M. Kramm36Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; Pomeranian Medical University, Szczecin, Poland; UCL GOS Institute of Child Health, London, UK; Correspondence to: Department of Paediatric Oncology, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, United Kingdom.Uppsala University, Uppsala, Sweden; Uppsala University Children's Hospital, Uppsala, SwedenGreat Ormond Street Hospital for Children NHS Foundation Trust, London, UK; UCL GOS Institute of Child Health, London, UKPrincess Máxima Center for Pediatric Oncology, Utrecht, NetherlandsInstitut Gustave Roussy, Villejuif, FranceFondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyFondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyUniversity Hospitals of Geneva, Geneva, SwitzerlandIstanbul University, Istanbul, TurkeyCentro Hospitalar Universitário de São João, Porto, PortugalPrincess Máxima Center for Pediatric Oncology, Utrecht, NetherlandsNorthern Institute for Cancer Research Sir James Spence Institute, Newcastle, UKHeidelberg University, Heidelberg, GermanyInstitut Gustave Roussy, Villejuif, FranceCambridge University Hospitals NHS Foundation Trust, Cambridge, UKCancer Consortium (DKTK) Dresden, GermanyAarhus Universitetshospital, Aarhus, DenmarkPrincess Máxima Center for Pediatric Oncology, Utrecht, NetherlandsUniversita degli Studi di Torino, Torino, ItalyGreat Ormond Street Hospital for Children NHS Foundation Trust, London, UKAlder Hey Children's NHS Foundation Trust, Liverpool, UKUniversität Augsburg Medizinische Fakultät, Uugsburg, GermanyPrincess Máxima Center for Pediatric Oncology, Utrecht, NetherlandsGreat Ormond Street Hospital for Children NHS Foundation Trust, London, UKCharité - Universitätsmedizin Berlin Campus Charite Mitte, Berlin, GermanyUppsala University, Uppsala, SwedenUppsala University, Uppsala, SwedenUniversity of Bonn, Bonn, GermanyCentre Hospitalier Sainte Anne, Paris, FranceGreat Ormond Street Hospital for Children NHS Foundation Trust, London, UK; UCL GOS Institute of Child Health, London, UKAmsterdam Universitair Medische Centra, Amsterdam, NetherlandsGerman Cancer Research Centre, Heidelberg, GermanyHospital for Sick Children, Toronto, CanadaHospital for Sick Children, Toronto, CanadaFunding neuro, Glasgow, UKII Fondo di GIO ONULUS, Trieste, ItalyUniversity of Gottingen, Gottingen, GermanyPaediatric high-grade gliomas (pedHGGs) are highly invasive brain tumours accounting for approximately 15 % of all central nervous system (CNS) tumours in children and adolescents. The outcome for these tumours is generally poor with 5-year survival rates of less than 20 %. Despite improved biological insights into pedHGGs and the promise of more effective therapies, little progress has been made in the effective treatment and the outcome of these tumours over the last four decades. Much of the evidence for the use of chemotherapy in pedHGGs is extrapolated from adult data, and the evidence for its use in the paediatric population is still weak. This guideline was written by members of the SIOPE HGG Working Group as part of the European Standard Clinical Practice (ESCP) Project. The guideline aims to integrate available evidence-based and expert opinion-based information to assist healthcare professionals in the management of pedHGGs and in an attempt to provide equity in healthcare reflecting the varying resources of each European country.http://www.sciencedirect.com/science/article/pii/S2772610X24000709High-grade gliomaChildrenPractice recommendations |
| spellingShingle | Elwira Szychot Géraldine Giraud Darren Hargrave Dannis van Vuurden Jacques Grill Veronica Biassoni Maura Massimo André O. Von Büren Rejin Kebudi Maria João Gil-da-Costa Sophie Veldhuijzen van Zanten Simon Bailey Michael Karremann Stephanie Bolle Thankamma Ajithkumar Mechthild Krause Yasmin Lassen-Ramshad Geert Janssens Giovanni Morana Ulrike Löbel Shivaram Avula Brigitte Bison Maarten Lequin Kristian Aquilina Ulrich Thomale Pelle Nilsson Sami Bui-Quy Abu Hamdeh Torsten Pietsch Pascale Varlet Thomas S. Jacques Pieter Wesseling David Jones Uri Tabori Anirban Das David Mulligan Francesca Kozmann Christof M. Kramm European standard clinical practice recommendations for paediatric high-grade gliomas EJC Paediatric Oncology High-grade glioma Children Practice recommendations |
| title | European standard clinical practice recommendations for paediatric high-grade gliomas |
| title_full | European standard clinical practice recommendations for paediatric high-grade gliomas |
| title_fullStr | European standard clinical practice recommendations for paediatric high-grade gliomas |
| title_full_unstemmed | European standard clinical practice recommendations for paediatric high-grade gliomas |
| title_short | European standard clinical practice recommendations for paediatric high-grade gliomas |
| title_sort | european standard clinical practice recommendations for paediatric high grade gliomas |
| topic | High-grade glioma Children Practice recommendations |
| url | http://www.sciencedirect.com/science/article/pii/S2772610X24000709 |
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