3D Fusion Framework for Infarction and Angiogenesis Analysis in a Myocardial Infarct Minipig Model
The combination of different modality images can provide detailed and comprehensive information for the prognostic assessment and therapeutic strategy of patients with ischemic heart disease. In this study, a 3D fusion framework is designed to integrate coronary computed tomography (CT) angiography...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-05-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1177/1536012117708735 |
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| author | Xu Zhenzhen PhD Bo Tao PhD, MD Yu Li MSc Jun Zhang PhD Xiaochao Qu PhD Feng Cao PhD Jimin Liang PhD |
| author_facet | Xu Zhenzhen PhD Bo Tao PhD, MD Yu Li MSc Jun Zhang PhD Xiaochao Qu PhD Feng Cao PhD Jimin Liang PhD |
| author_sort | Xu Zhenzhen PhD |
| collection | DOAJ |
| description | The combination of different modality images can provide detailed and comprehensive information for the prognostic assessment and therapeutic strategy of patients with ischemic heart disease. In this study, a 3D fusion framework is designed to integrate coronary computed tomography (CT) angiography (CTA), 2-deoxy-2-[ 18 F]fluoro-D-glucose ([ 18 F]DG) positron emission tomography (PET)/CT, and [ 68 Ga]-1,4,7-triazacyclononane-1,4,7-triacetic acid-(Arg-Gly-Asp)2 ([ 68 Ga]-NOTA-PRGD2) PET/CT images of the myocardial infarction model in minipigs. First, the structural anatomy of the heart in coronary CTA and CT is segmented using a multi-atlas-based method. Then, the hearts are registered using the B-spline-based free form deformation. Finally, the [ 18 F]DG and [ 68 Ga]-NOTA-PRGD2 signals are mapped into the heart in coronary CTA, which produces a single fusion image to delineate both the cardiac structural anatomy and the functional information of myocardial viability and angiogenesis. Heart segmentation demonstrates high accuracy with good agreement between manual delineation and automatic segmentation. The fusion result intuitively reflects the extent of the [ 18 F]DG uptake defect as well as the location where the [ 68 Ga]-NOTA-PRGD2 signal appears. The fusion result verified the occurrence of angiogenesis based on the in vivo noninvasive molecular imaging approach. The presented framework is helpful in facilitating the study of the relationship between infarct territories and blocked coronary arteries as well as angiogenesis. |
| format | Article |
| id | doaj-art-7dc36a2ba6ab4b8c9f1d1a0d9b91e5ad |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2017-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-7dc36a2ba6ab4b8c9f1d1a0d9b91e5ad2025-01-02T23:11:16ZengSAGE PublishingMolecular Imaging1536-01212017-05-011610.1177/153601211770873510.1177_15360121177087353D Fusion Framework for Infarction and Angiogenesis Analysis in a Myocardial Infarct Minipig ModelXu Zhenzhen PhD0Bo Tao PhD, MD1Yu Li MSc2Jun Zhang PhD3Xiaochao Qu PhD4Feng Cao PhD5Jimin Liang PhD6 Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi, China Department of Cardiology, Chinese PLA General Hospital, Beijing, China Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi, China Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi, China Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi, China Department of Cardiology, Chinese PLA General Hospital, Beijing, China Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi, ChinaThe combination of different modality images can provide detailed and comprehensive information for the prognostic assessment and therapeutic strategy of patients with ischemic heart disease. In this study, a 3D fusion framework is designed to integrate coronary computed tomography (CT) angiography (CTA), 2-deoxy-2-[ 18 F]fluoro-D-glucose ([ 18 F]DG) positron emission tomography (PET)/CT, and [ 68 Ga]-1,4,7-triazacyclononane-1,4,7-triacetic acid-(Arg-Gly-Asp)2 ([ 68 Ga]-NOTA-PRGD2) PET/CT images of the myocardial infarction model in minipigs. First, the structural anatomy of the heart in coronary CTA and CT is segmented using a multi-atlas-based method. Then, the hearts are registered using the B-spline-based free form deformation. Finally, the [ 18 F]DG and [ 68 Ga]-NOTA-PRGD2 signals are mapped into the heart in coronary CTA, which produces a single fusion image to delineate both the cardiac structural anatomy and the functional information of myocardial viability and angiogenesis. Heart segmentation demonstrates high accuracy with good agreement between manual delineation and automatic segmentation. The fusion result intuitively reflects the extent of the [ 18 F]DG uptake defect as well as the location where the [ 68 Ga]-NOTA-PRGD2 signal appears. The fusion result verified the occurrence of angiogenesis based on the in vivo noninvasive molecular imaging approach. The presented framework is helpful in facilitating the study of the relationship between infarct territories and blocked coronary arteries as well as angiogenesis.https://doi.org/10.1177/1536012117708735 |
| spellingShingle | Xu Zhenzhen PhD Bo Tao PhD, MD Yu Li MSc Jun Zhang PhD Xiaochao Qu PhD Feng Cao PhD Jimin Liang PhD 3D Fusion Framework for Infarction and Angiogenesis Analysis in a Myocardial Infarct Minipig Model Molecular Imaging |
| title | 3D Fusion Framework for Infarction and Angiogenesis Analysis in a
Myocardial Infarct Minipig Model |
| title_full | 3D Fusion Framework for Infarction and Angiogenesis Analysis in a
Myocardial Infarct Minipig Model |
| title_fullStr | 3D Fusion Framework for Infarction and Angiogenesis Analysis in a
Myocardial Infarct Minipig Model |
| title_full_unstemmed | 3D Fusion Framework for Infarction and Angiogenesis Analysis in a
Myocardial Infarct Minipig Model |
| title_short | 3D Fusion Framework for Infarction and Angiogenesis Analysis in a
Myocardial Infarct Minipig Model |
| title_sort | 3d fusion framework for infarction and angiogenesis analysis in a myocardial infarct minipig model |
| url | https://doi.org/10.1177/1536012117708735 |
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