Serum lipid profile in systemic lupus erythematosus
BackgroundDyslipidemia presents in various autoimmune diseases, and the serum lipid profile in systemic lupus erythematosus (SLE) has not yet been clearly defined. This study aims to evaluate the level of serum lipids in patients with SLE.MethodsA case–control study evaluated four conventional sera...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1503434/full |
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| author | Jingxiu Xuan Jingxiu Xuan Jingxiu Xuan Chaoqiong Deng Huiqin Lu Yan He Yan He Yan He Jimin Zhang Xiaoli Zeng Xiaoli Zeng Yuechi Sun Yuechi Sun Yuechi Sun Shiju Chen Shiju Chen Shiju Chen Yuan Liu Yuan Liu Yuan Liu |
| author_facet | Jingxiu Xuan Jingxiu Xuan Jingxiu Xuan Chaoqiong Deng Huiqin Lu Yan He Yan He Yan He Jimin Zhang Xiaoli Zeng Xiaoli Zeng Yuechi Sun Yuechi Sun Yuechi Sun Shiju Chen Shiju Chen Shiju Chen Yuan Liu Yuan Liu Yuan Liu |
| author_sort | Jingxiu Xuan |
| collection | DOAJ |
| description | BackgroundDyslipidemia presents in various autoimmune diseases, and the serum lipid profile in systemic lupus erythematosus (SLE) has not yet been clearly defined. This study aims to evaluate the level of serum lipids in patients with SLE.MethodsA case–control study evaluated four conventional sera lipids—total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL)—in patients with SLE compared to healthy controls (HCs). Correlations between serum lipids and clinical characteristics were analyzed in patients with SLE. A systematic review and meta-analysis were conducted to assess the epidemiology of lipid profiles in patients with SLE, and a random-effects meta-analysis was performed for data synthesis.ResultsTC and TG were elevated significantly, and HDL decreased in patients with SLE compared to HCs. Elevated lipids were associated with progressive disease activity. TC, TG, and HDL were elevated in patients with SLE and were associated with decreased IgG, increased 24-h proteinuria, white blood cells (WBCs), and neutrophils. Decreased HDL and increased TG were associated with an increase in the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Patients with SLE who took glucocorticoids (GCs) may have experienced increases in TC and TG, while those who took hydroxychloroquine (HCQ) may have experienced increases in TC and HDL. Eleven eligible studies including the present study on associations between serum lipids and SLE were reviewed by the meta-analysis. The results demonstrated elevated TC (MD = 0.85, 95% CI 0.82 to 0.89, p < 0.00001) and TG (MD = 0.96, 95% CI 0.94 to 0.99, p < 0.00001) levels in SLE, while HDL decreased (MD = −0.19, 95% CI −0.20 to −0.17, p < 0.00001).ConclusionsDyslipidemia is present in SLE. There was a significant association between SLE disease activity and TC, TG, and HDL. The exact pathogenesis of metabolic disorders in SLE needs to be further addressed. |
| format | Article |
| id | doaj-art-7dc2fe5e843b4206a39cfdc3e928de75 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-7dc2fe5e843b4206a39cfdc3e928de752025-01-14T05:10:21ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15034341503434Serum lipid profile in systemic lupus erythematosusJingxiu Xuan0Jingxiu Xuan1Jingxiu Xuan2Chaoqiong Deng3Huiqin Lu4Yan He5Yan He6Yan He7Jimin Zhang8Xiaoli Zeng9Xiaoli Zeng10Yuechi Sun11Yuechi Sun12Yuechi Sun13Shiju Chen14Shiju Chen15Shiju Chen16Yuan Liu17Yuan Liu18Yuan Liu19Department of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaXiamen Municipal Clinical Research Center for Immune Diseases, Xiamen, ChinaXiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, Fujian, ChinaDepartment of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaDepartment of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaDepartment of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaXiamen Municipal Clinical Research Center for Immune Diseases, Xiamen, ChinaXiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, Fujian, ChinaDepartment of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaDepartment of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaXiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, Fujian, ChinaDepartment of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaXiamen Municipal Clinical Research Center for Immune Diseases, Xiamen, ChinaXiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, Fujian, ChinaDepartment of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaXiamen Municipal Clinical Research Center for Immune Diseases, Xiamen, ChinaXiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, Fujian, ChinaDepartment of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, ChinaXiamen Municipal Clinical Research Center for Immune Diseases, Xiamen, ChinaXiamen Key Laboratory of Rheumatology and Clinical Immunology, Xiamen, Fujian, ChinaBackgroundDyslipidemia presents in various autoimmune diseases, and the serum lipid profile in systemic lupus erythematosus (SLE) has not yet been clearly defined. This study aims to evaluate the level of serum lipids in patients with SLE.MethodsA case–control study evaluated four conventional sera lipids—total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL)—in patients with SLE compared to healthy controls (HCs). Correlations between serum lipids and clinical characteristics were analyzed in patients with SLE. A systematic review and meta-analysis were conducted to assess the epidemiology of lipid profiles in patients with SLE, and a random-effects meta-analysis was performed for data synthesis.ResultsTC and TG were elevated significantly, and HDL decreased in patients with SLE compared to HCs. Elevated lipids were associated with progressive disease activity. TC, TG, and HDL were elevated in patients with SLE and were associated with decreased IgG, increased 24-h proteinuria, white blood cells (WBCs), and neutrophils. Decreased HDL and increased TG were associated with an increase in the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Patients with SLE who took glucocorticoids (GCs) may have experienced increases in TC and TG, while those who took hydroxychloroquine (HCQ) may have experienced increases in TC and HDL. Eleven eligible studies including the present study on associations between serum lipids and SLE were reviewed by the meta-analysis. The results demonstrated elevated TC (MD = 0.85, 95% CI 0.82 to 0.89, p < 0.00001) and TG (MD = 0.96, 95% CI 0.94 to 0.99, p < 0.00001) levels in SLE, while HDL decreased (MD = −0.19, 95% CI −0.20 to −0.17, p < 0.00001).ConclusionsDyslipidemia is present in SLE. There was a significant association between SLE disease activity and TC, TG, and HDL. The exact pathogenesis of metabolic disorders in SLE needs to be further addressed.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1503434/fullserum lipidssystemic lupus erythematosusdisease activitymeta-analysissystemic review |
| spellingShingle | Jingxiu Xuan Jingxiu Xuan Jingxiu Xuan Chaoqiong Deng Huiqin Lu Yan He Yan He Yan He Jimin Zhang Xiaoli Zeng Xiaoli Zeng Yuechi Sun Yuechi Sun Yuechi Sun Shiju Chen Shiju Chen Shiju Chen Yuan Liu Yuan Liu Yuan Liu Serum lipid profile in systemic lupus erythematosus Frontiers in Immunology serum lipids systemic lupus erythematosus disease activity meta-analysis systemic review |
| title | Serum lipid profile in systemic lupus erythematosus |
| title_full | Serum lipid profile in systemic lupus erythematosus |
| title_fullStr | Serum lipid profile in systemic lupus erythematosus |
| title_full_unstemmed | Serum lipid profile in systemic lupus erythematosus |
| title_short | Serum lipid profile in systemic lupus erythematosus |
| title_sort | serum lipid profile in systemic lupus erythematosus |
| topic | serum lipids systemic lupus erythematosus disease activity meta-analysis systemic review |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1503434/full |
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