Phosphorylation of a nuclear condensate regulates cohesion and mRNA retention

Abstract Nuclear speckles are membraneless organelles that associate with active transcription sites and participate in post-transcriptional mRNA processing. During the cell cycle, nuclear speckles dissolve following phosphorylation of their protein components. Here, we identify the PP1 family as th...

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Bibliographic Details
Main Authors: Alexa B. R. McIntyre, Adrian Beat Tschan, Katrina Meyer, Severin Walser, Arpan Kumar Rai, Keisuke Fujita, Lucas Pelkmans
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55469-3
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