STUDY OF THE EFFECT OF METHIONINE HYPERHOMOCYSTEINEMIA AND ITS CORRECTION WITH CHOLINE AND VITAMIN D ON THE CONDITION OF THE PERIODONTIUM, SMALL INTESTINE, AND LIVER OF RATS
In recent years, there have been reports of a clinical relationship between periodontitis, intestinal and liver diseases of the human body, the so-called "oral-intestinal-hepatic axis", although the causal mechanism of such an "association" is still unclear. Aim. The study aim...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Danylo Halytsky Lviv National Medical University
2024-10-01
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| Series: | Acta Medica Leopoliensia |
| Subjects: | |
| Online Access: | https://amljournal.com/index.php/journal/article/view/399 |
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| Summary: | In recent years, there have been reports of a clinical relationship between periodontitis, intestinal and liver diseases of the human body, the so-called "oral-intestinal-hepatic axis", although the causal mechanism of such an "association" is still unclear.
Aim. The study aims to investigate the functional state of the liver, small intestine, and periodontium of rats against the background of long-term methionine-induced hyperhomocysteinemia and vitamin D deficiency and its correction with choline and vitamin D.
Materials and Methods. The study, lasting 8 weeks, was conducted on 36 adult rats of both sexes, aged 5 months. Experimental hyperhomocysteinemia was reproduced according to current recommendations, and its correction was carried out with the help of choline and vitamin D. Biochemical parameters in blood and homogenates were studied and compared, and the degree of alveolar atrophy was determined.
Results. The experimental study confirmed the data of previous studies that with long-term methionine hyperhomocysteinemia in rats, moderate periodontal damage occurs, which remotely resembles the clinical picture of generalized periodontitis of a mild degree of severity in humans.
Discussion. In experimental animals, hyperhomocysteinemia causes a number of aberrations in the blood, intestines, and liver (high level of homocysteine, oxidative stress, inhibition of antioxidant protection, decreased vitamin D levels, changes in the activity of liver enzymes, disturbances in calcium metabolism).
Conclusions. Changes in the periodontium, intestines, and liver of experimental animals that occur against the background of hyperhomocysteinemia confirm the presence of an "oral-intestinal-hepatic" association. Enriching the diet with choline and vitamin D significantly reduces the indicated disorders, namely: prevents the occurrence of resorption processes in the alveoli of the jaws, and improves the functional state of the small intestine and liver. Increased excretion of calcium from the body of rats with urine indicates a violation of bone metabolism, which may be a consequence of calcium deficiency in animals with hyperhomo-cysteinemia. So, there is a relationship between the oral cavity, the small intestine, and the liver, which was confirmed by our research, but it is difficult to answer what pathology in this triad precedes and causes a chain reaction. The given narratives about the problems of the "mouth-intestine-liver" axis provide hope for a possible new practical step in dentistry. |
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| ISSN: | 1029-4244 2415-3303 |