Analysis of mRNA Pentatricopeptide Repeat Domain 1 as a prospective oncogene in clear cell renal cell carcinoma that accelerates tumor cells proliferation and invasion via the Akt/GSK3β/β-catenin pathway

Analysis of mRNA Pentatricopeptide Repeat Domain 1 as a prospective oncogene in clear cell renal cell carcinoma that accelerates tumor cells proliferation and invasion via the Akt/GSK3β/β-catenin pathway

Abstract Background Although pentatricopeptide repeat domain 1 (PTCD1) has been found to modulate mitochondrial metabolic and oxidative phosphorylation, its contribution in the growth of clear cell renal cell carcinoma (ccRCC) remains unknown. Methods The Cancer Genome Atlas (TCGA) dataset was utili...

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Bibliographic Details
Main Authors: Zhongbao Zhou, Yulong Li, Yumeng Chai, Yong Zhang, Pu Yan
Format: Article
Language:English
Published: Springer 2025-01-01
Series:Discover Oncology
Subjects:
Pentatricopeptide repeat domain 1
Clear cell renal cell carcinoma
Biomarker
Prognosis
Immune microenvironment
Weighted Gene Coexpression Network Analysis
Online Access:https://doi.org/10.1007/s12672-025-01764-4
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