Сardioprotective agents with biaromatic structure. Part 3. Sodium channel blockers
This review continues a series of reviews on the analysis of compounds with cardioprotective properties in a number of biaromatic structures, which include a range of sodium channel blockers. Among voltage-gated sodium channels, the Nav1.5 isoform is the most abundant in the heart. Sodium channel bl...
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2022-12-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/326 |
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| _version_ | 1849345327814934528 |
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| author | G. V. Mokrov |
| author_facet | G. V. Mokrov |
| author_sort | G. V. Mokrov |
| collection | DOAJ |
| description | This review continues a series of reviews on the analysis of compounds with cardioprotective properties in a number of biaromatic structures, which include a range of sodium channel blockers. Among voltage-gated sodium channels, the Nav1.5 isoform is the most abundant in the heart. Sodium channel blockers have historically been called "class I antiarrhythmics". Among the compounds of this type, a biaromatic structure mainly have the Nav1.5 late current blockers belonging to the Id subclass of antiarrhythmic drugs. Leader molecules from this subgroup, such as ranolazine, GS-458967, and F15845, reduce action potential recovery time and suppress trigger activity induced by early post-depolarization. They are effective for the treatment of stable angina and ventricular tachycardia. |
| format | Article |
| id | doaj-art-7d7b5b1d337342b49e6d0f3fbf3d161d |
| institution | Kabale University |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2022-12-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-7d7b5b1d337342b49e6d0f3fbf3d161d2025-08-20T03:42:30ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302022-12-01033910.37489/2587-7836-2022-3-3-9305Сardioprotective agents with biaromatic structure. Part 3. Sodium channel blockersG. V. Mokrov0FSBI «Zakusov Institute of Pharmacology»This review continues a series of reviews on the analysis of compounds with cardioprotective properties in a number of biaromatic structures, which include a range of sodium channel blockers. Among voltage-gated sodium channels, the Nav1.5 isoform is the most abundant in the heart. Sodium channel blockers have historically been called "class I antiarrhythmics". Among the compounds of this type, a biaromatic structure mainly have the Nav1.5 late current blockers belonging to the Id subclass of antiarrhythmic drugs. Leader molecules from this subgroup, such as ranolazine, GS-458967, and F15845, reduce action potential recovery time and suppress trigger activity induced by early post-depolarization. They are effective for the treatment of stable angina and ventricular tachycardia.https://www.pharmacokinetica.ru/jour/article/view/326аntiarrhythmicscardioprotectorsna-channels blockersbiaromatic compounds |
| spellingShingle | G. V. Mokrov Сardioprotective agents with biaromatic structure. Part 3. Sodium channel blockers Фармакокинетика и Фармакодинамика аntiarrhythmics cardioprotectors na-channels blockers biaromatic compounds |
| title | Сardioprotective agents with biaromatic structure. Part 3. Sodium channel blockers |
| title_full | Сardioprotective agents with biaromatic structure. Part 3. Sodium channel blockers |
| title_fullStr | Сardioprotective agents with biaromatic structure. Part 3. Sodium channel blockers |
| title_full_unstemmed | Сardioprotective agents with biaromatic structure. Part 3. Sodium channel blockers |
| title_short | Сardioprotective agents with biaromatic structure. Part 3. Sodium channel blockers |
| title_sort | сardioprotective agents with biaromatic structure part 3 sodium channel blockers |
| topic | аntiarrhythmics cardioprotectors na-channels blockers biaromatic compounds |
| url | https://www.pharmacokinetica.ru/jour/article/view/326 |
| work_keys_str_mv | AT gvmokrov sardioprotectiveagentswithbiaromaticstructurepart3sodiumchannelblockers |