Bacteria-specific modified nucleoside is released and elevated in urine of patients with bacterial infections

Bacteria-specific modified nucleoside is released and elevated in urine of patients with bacterial infections

ABSTRACT Over 170 types of chemical modifications have been identified in cellular RNAs across the three domains of life. Modified RNA is eventually degraded to constituent nucleosides, and in mammals, modified nucleosides are released into the extracellular space. By contrast, the fate of modified...

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Main Authors: Ryosuke Yamamura, Yu Nagayoshi, Kayo Nishiguchi, Hitomi Kaneko, Keiichi Yamamoto, Koki Matsushita, Miho Shimamura, Akihiro Kunisawa, Korin Sakakida, Takeshi Chujo, Masataka Adachi, Yutaka Kakizoe, Yuichiro Izumi, Takashige Kuwabara, Masashi Mukoyama, Kazuhito Tomizawa
Format: Article
Language:English
Published: American Society for Microbiology 2025-01-01
Series:mBio
Subjects:
modified nucleoside
bacterial infection
biomarker
LC-MS
RNA modification
Online Access:https://journals.asm.org/doi/10.1128/mbio.03124-24
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https://journals.asm.org/doi/10.1128/mbio.03124-24

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