Scatter Artifact with Ga-68-PSMA-11 PET: Severity Reduced With Furosemide Diuresis and Improved Scatter Correction
Purpose: To assess the utility of furosemide diuresis and the role of an improved scatter correction algorithm in reducing scatter artifact severity on Ga-68- Prostate-specific membrane antigen (PSMA)-11 positron emission tomography (PET). Materials and Methods: A total of 139 patients underwent Ga-...
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SAGE Publishing
2018-11-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1177/1536012118811741 |
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| author | Courtney Lawhn-Heath MD Robert R. Flavell MD, PhD David E. Korenchan PhD Timothy Deller MSEE Spencer Lake MD Peter R. Carroll MD, MPH Thomas A. Hope MD |
| author_facet | Courtney Lawhn-Heath MD Robert R. Flavell MD, PhD David E. Korenchan PhD Timothy Deller MSEE Spencer Lake MD Peter R. Carroll MD, MPH Thomas A. Hope MD |
| author_sort | Courtney Lawhn-Heath MD |
| collection | DOAJ |
| description | Purpose: To assess the utility of furosemide diuresis and the role of an improved scatter correction algorithm in reducing scatter artifact severity on Ga-68- Prostate-specific membrane antigen (PSMA)-11 positron emission tomography (PET). Materials and Methods: A total of 139 patients underwent Ga-68-PSMA-11 PET imaging for prostate cancer: 47 non-time-of-flight (non-TOF) PET/computed tomography, 51 PET/magnetic resonance imaging (MRI) using the standard TOF scatter correction algorithm, and 41 PET/MRI using an improved TOF scatter correction algorithm. Whole-body PET acquisitions were subdivided into 3 regions: around kidneys; between kidneys and bladder; and around bladder. The images were reviewed, and scatter artifact severity was rated using a Likert-type scale. Results: The worst scatter occurred when using non-TOF scatter correction without furosemide, where 42.1% of patients demonstrated severe scatter artifacts in 1 or more regions. Improved TOF scatter correction resulted in the smallest percentage of studies with severe scatter (6.5%). Scatter ratings by region were lowest using improved TOF scatter correction. Furosemide reduced mean scatter severity when using non-TOF and standard TOF. Conclusions: Both furosemide and scatter correction algorithm play a role in reducing scatter in PSMA PET. Improved TOF scatter correction resulted in the lowest scatter severity. |
| format | Article |
| id | doaj-art-7d649b2735224e03bff64cf19ffc8852 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2018-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-7d649b2735224e03bff64cf19ffc88522025-01-02T22:38:20ZengSAGE PublishingMolecular Imaging1536-01212018-11-011710.1177/1536012118811741Scatter Artifact with Ga-68-PSMA-11 PET: Severity Reduced With Furosemide Diuresis and Improved Scatter CorrectionCourtney Lawhn-Heath MD0Robert R. Flavell MD, PhD1David E. Korenchan PhD2Timothy Deller MSEE3Spencer Lake MD4Peter R. Carroll MD, MPH5Thomas A. Hope MD6 Department of Radiology and Biomedical Imaging, University of California–San Francisco, San Francisco, CA, USA Department of Radiology and Biomedical Imaging, University of California–San Francisco, San Francisco, CA, USA Department of Radiology and Biomedical Imaging, University of California–San Francisco, San Francisco, CA, USA GE Healthcare, Waukesha, WI, USA Department of Radiology and Biomedical Imaging, University of California–San Francisco, San Francisco, CA, USA Department of Urology, University of California–San Francisco, San Francisco, CA, USA Department of Radiology, San Francisco VA Medical Center, San Francisco, CA, USAPurpose: To assess the utility of furosemide diuresis and the role of an improved scatter correction algorithm in reducing scatter artifact severity on Ga-68- Prostate-specific membrane antigen (PSMA)-11 positron emission tomography (PET). Materials and Methods: A total of 139 patients underwent Ga-68-PSMA-11 PET imaging for prostate cancer: 47 non-time-of-flight (non-TOF) PET/computed tomography, 51 PET/magnetic resonance imaging (MRI) using the standard TOF scatter correction algorithm, and 41 PET/MRI using an improved TOF scatter correction algorithm. Whole-body PET acquisitions were subdivided into 3 regions: around kidneys; between kidneys and bladder; and around bladder. The images were reviewed, and scatter artifact severity was rated using a Likert-type scale. Results: The worst scatter occurred when using non-TOF scatter correction without furosemide, where 42.1% of patients demonstrated severe scatter artifacts in 1 or more regions. Improved TOF scatter correction resulted in the smallest percentage of studies with severe scatter (6.5%). Scatter ratings by region were lowest using improved TOF scatter correction. Furosemide reduced mean scatter severity when using non-TOF and standard TOF. Conclusions: Both furosemide and scatter correction algorithm play a role in reducing scatter in PSMA PET. Improved TOF scatter correction resulted in the lowest scatter severity.https://doi.org/10.1177/1536012118811741 |
| spellingShingle | Courtney Lawhn-Heath MD Robert R. Flavell MD, PhD David E. Korenchan PhD Timothy Deller MSEE Spencer Lake MD Peter R. Carroll MD, MPH Thomas A. Hope MD Scatter Artifact with Ga-68-PSMA-11 PET: Severity Reduced With Furosemide Diuresis and Improved Scatter Correction Molecular Imaging |
| title | Scatter Artifact with Ga-68-PSMA-11 PET: Severity Reduced With Furosemide Diuresis and Improved Scatter Correction |
| title_full | Scatter Artifact with Ga-68-PSMA-11 PET: Severity Reduced With Furosemide Diuresis and Improved Scatter Correction |
| title_fullStr | Scatter Artifact with Ga-68-PSMA-11 PET: Severity Reduced With Furosemide Diuresis and Improved Scatter Correction |
| title_full_unstemmed | Scatter Artifact with Ga-68-PSMA-11 PET: Severity Reduced With Furosemide Diuresis and Improved Scatter Correction |
| title_short | Scatter Artifact with Ga-68-PSMA-11 PET: Severity Reduced With Furosemide Diuresis and Improved Scatter Correction |
| title_sort | scatter artifact with ga 68 psma 11 pet severity reduced with furosemide diuresis and improved scatter correction |
| url | https://doi.org/10.1177/1536012118811741 |
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