Inhibiting Tyrosine Kinase 2 Ameliorates Antiphospholipid Syndrome Nephropathy
Conclusion: Our results demonstrated the key role of type I IFN in the pathogenesis of APS nephropathy. Furthermore, the therapeutic efficacy of Tyk2 inhibition was demonstrated in a murine model of APS nephropathy. Our results could provide a new treatment strategy for this debilitating disease.
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/mi/5568822 |
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| _version_ | 1846099176027324416 |
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| author | Kuo-Tung Tang Yu-Sin Chen Tzu-Ting Chen Ya-Hsuan Chao Shu-Ping Kung Der-Yuan Chen Chi-Chien Lin |
| author_facet | Kuo-Tung Tang Yu-Sin Chen Tzu-Ting Chen Ya-Hsuan Chao Shu-Ping Kung Der-Yuan Chen Chi-Chien Lin |
| author_sort | Kuo-Tung Tang |
| collection | DOAJ |
| description | Conclusion: Our results demonstrated the key role of type I IFN in the pathogenesis of APS nephropathy. Furthermore, the therapeutic efficacy of Tyk2 inhibition was demonstrated in a murine model of APS nephropathy. Our results could provide a new treatment strategy for this debilitating disease. |
| format | Article |
| id | doaj-art-7d5925867abc41a5808ec39eec7372c4 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-7d5925867abc41a5808ec39eec7372c42025-01-01T00:00:01ZengWileyMediators of Inflammation1466-18612024-01-01202410.1155/mi/5568822Inhibiting Tyrosine Kinase 2 Ameliorates Antiphospholipid Syndrome NephropathyKuo-Tung Tang0Yu-Sin Chen1Tzu-Ting Chen2Ya-Hsuan Chao3Shu-Ping Kung4Der-Yuan Chen5Chi-Chien Lin6Division of AllergyGraduate Institute of BiotechnologyInstitute of Bioinformatics and Structural Biology and Department of Medical ScienceInstitute of Biomedical ScienceInstitute of Biomedical ScienceCollege of MedicineDepartment of Medical ResearchConclusion: Our results demonstrated the key role of type I IFN in the pathogenesis of APS nephropathy. Furthermore, the therapeutic efficacy of Tyk2 inhibition was demonstrated in a murine model of APS nephropathy. Our results could provide a new treatment strategy for this debilitating disease.http://dx.doi.org/10.1155/mi/5568822 |
| spellingShingle | Kuo-Tung Tang Yu-Sin Chen Tzu-Ting Chen Ya-Hsuan Chao Shu-Ping Kung Der-Yuan Chen Chi-Chien Lin Inhibiting Tyrosine Kinase 2 Ameliorates Antiphospholipid Syndrome Nephropathy Mediators of Inflammation |
| title | Inhibiting Tyrosine Kinase 2 Ameliorates Antiphospholipid Syndrome Nephropathy |
| title_full | Inhibiting Tyrosine Kinase 2 Ameliorates Antiphospholipid Syndrome Nephropathy |
| title_fullStr | Inhibiting Tyrosine Kinase 2 Ameliorates Antiphospholipid Syndrome Nephropathy |
| title_full_unstemmed | Inhibiting Tyrosine Kinase 2 Ameliorates Antiphospholipid Syndrome Nephropathy |
| title_short | Inhibiting Tyrosine Kinase 2 Ameliorates Antiphospholipid Syndrome Nephropathy |
| title_sort | inhibiting tyrosine kinase 2 ameliorates antiphospholipid syndrome nephropathy |
| url | http://dx.doi.org/10.1155/mi/5568822 |
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